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    REG4 regenerating family member 4 [ Homo sapiens (human) ]

    Gene ID: 83998, updated on 15-Jun-2019

    Summary

    Official Symbol
    REG4provided by HGNC
    Official Full Name
    regenerating family member 4provided by HGNC
    Primary source
    HGNC:HGNC:22977
    See related
    Ensembl:ENSG00000134193 MIM:609846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GISP; RELP; REG-IV
    Expression
    Biased expression in small intestine (RPKM 174.4), colon (RPKM 137.8) and 2 other tissues See more
    Orthologs

    Genomic context

    See REG4 in Genome Data Viewer
    Location:
    1p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (119794018..119811580, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (120336641..120354203, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphoglycerate dehydrogenase Neighboring gene uncharacterized LOC105378936 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA synthase 2 Neighboring gene uncharacterized LOC105378938 Neighboring gene NBPF member 7 Neighboring gene profilin 1 pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mannan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mannan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    regenerating islet-derived protein 4
    Names
    REG-4
    REG-like protein
    gastrointestinal secretory protein
    reg IV
    regenerating gene type IV
    regenerating islet-derived family, member 4
    regenerating islet-derived protein IV

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159352.2NP_001152824.1  regenerating islet-derived protein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001152824.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL359752, AY126670
      Consensus CDS
      CCDS906.1
      UniProtKB/Swiss-Prot
      Q9BYZ8
      UniProtKB/TrEMBL
      A0A024R0M1
      Related
      ENSP00000346158.1, ENST00000354219.5
      Conserved Domains (1) summary
      cd03594
      Location:30156
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
    2. NM_001159353.2NP_001152825.1  regenerating islet-derived protein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001152825.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons but has an alternate 3' end, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL359752, AY126672
      Consensus CDS
      CCDS53354.1
      UniProtKB/Swiss-Prot
      Q9BYZ8
      Related
      ENSP00000358409.4, ENST00000369401.4
      Conserved Domains (1) summary
      cl02432
      Location:3055
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    3. NM_032044.4NP_114433.1  regenerating islet-derived protein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_114433.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AL359752, AY007243, AY126670
      Consensus CDS
      CCDS906.1
      UniProtKB/Swiss-Prot
      Q9BYZ8
      UniProtKB/TrEMBL
      A0A024R0M1
      Related
      ENSP00000256585.5, ENST00000256585.10
      Conserved Domains (1) summary
      cd03594
      Location:30156
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      119794017..119811460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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