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    EIF2A eukaryotic translation initiation factor 2A [ Homo sapiens (human) ]

    Gene ID: 83939, updated on 7-Jul-2019

    Summary

    Official Symbol
    EIF2Aprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:3254
    See related
    Ensembl:ENSG00000144895 MIM:609234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDA02; EIF-2A; MST089; MSTP004; MSTP089
    Summary
    This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
    Annotation information
    Note: EIF2A (Gene ID: 83939) and EIF2S1 (Gene ID: 1965) share the EIF2A symbol/alias in common. EIF2A is a widely used alternative name for eukaryotic translation initiation factor 2 subunit alpha (EIF2S1), which can be confused with the official symbol for eukaryotic translation initiation factor 2A (EIF2A). [05 Jul 2018]
    Expression
    Ubiquitous expression in thyroid (RPKM 30.8), ovary (RPKM 23.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See EIF2A in Genome Data Viewer
    Location:
    3q25.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (150546678..150586016)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150264465..150303803)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene TSC22 domain family member 2 Neighboring gene stress associated endoplasmic reticulum protein 1 Neighboring gene Sin3A associated protein 30kDa pseudogene Neighboring gene selenoprotein T Neighboring gene glutamate rich 6 Neighboring gene ERICH6 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat increases phosphorylation of EIF2A in astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribosome binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    tRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation initiation factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    SREBP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to amino acid starvation IEA
    Inferred from Electronic Annotation
    more info
     
    ribosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    blood microparticle HDA PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    eukaryotic translation initiation factor 2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space HDA PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2A
    Names
    65 kDa eukaryotic translation initiation factor 2A
    eukaryotic translation initiation factor 2A, 65kDa

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001319043.1NP_001305972.1  eukaryotic translation initiation factor 2A isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC107426, AF212241, AI560242, AK298586, DA382303
      Consensus CDS
      CCDS82861.1
      UniProtKB/Swiss-Prot
      Q9BY44
      Related
      ENSP00000420537.1, ENST00000487799.5
      Conserved Domains (3) summary
      pfam05308
      Location:411496
      Mito_fiss_reg; Mitochondrial fission regulator
      pfam08662
      Location:191386
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:252286
      7WD40; WD40 repeat [structural motif]
    2. NM_001319044.1NP_001305973.1  eukaryotic translation initiation factor 2A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC107426, AF212241, AI560242, AK293993, DA382303
      Consensus CDS
      CCDS82859.1
      UniProtKB/Swiss-Prot
      Q9BY44
      Related
      ENSP00000385292.3, ENST00000406576.7
      Conserved Domains (3) summary
      pfam05308
      Location:375460
      Mito_fiss_reg; Mitochondrial fission regulator
      pfam08662
      Location:155350
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:4281
      7WD40; WD40 repeat [structural motif]
    3. NM_001319045.1NP_001305974.1  eukaryotic translation initiation factor 2A isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in an internal exon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC107426, AF212241, AI560242, BX647951, DA382303
      Consensus CDS
      CCDS82860.1
      UniProtKB/Swiss-Prot
      Q9BY44
      UniProtKB/TrEMBL
      F8WAE5
      Related
      ENSP00000273435.5, ENST00000273435.9
      Conserved Domains (4) summary
      pfam05308
      Location:431516
      Mito_fiss_reg; Mitochondrial fission regulator
      pfam08662
      Location:211406
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:272306
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:45138
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_001319046.1NP_001305975.1  eukaryotic translation initiation factor 2A isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the 5' UTR and 5' coding region and initiates translation at an alternate start site, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC107426, AF109358, AI560242, DA382303
      UniProtKB/Swiss-Prot
      Q9BY44
      Conserved Domains (3) summary
      pfam05308
      Location:222307
      Mito_fiss_reg; Mitochondrial fission regulator
      pfam08662
      Location:6197
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:6397
      7WD40; WD40 repeat [structural motif]
    5. NM_032025.5NP_114414.2  eukaryotic translation initiation factor 2A isoform 1

      See identical proteins and their annotated locations for NP_114414.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC107426
      Consensus CDS
      CCDS46935.1
      UniProtKB/Swiss-Prot
      Q9BY44
      Related
      ENSP00000417229.1, ENST00000460851.6
      Conserved Domains (3) summary
      pfam05308
      Location:436521
      Mito_fiss_reg; Mitochondrial fission regulator
      pfam08662
      Location:216411
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:277311
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      150546678..150586016
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513224.2XP_011511526.1  eukaryotic translation initiation factor 2A isoform X1

      Conserved Domains (2) summary
      pfam08662
      Location:216411
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:277311
      7WD40; WD40 repeat [structural motif]
    2. XM_024453787.1XP_024309555.1  eukaryotic translation initiation factor 2A isoform X2

      Related
      ENSP00000420611.1, ENST00000465535.1
      Conserved Domains (2) summary
      pfam08662
      Location:1186
      eIF2A; Eukaryotic translation initiation factor eIF2A
      sd00039
      Location:5286
      7WD40; WD40 repeat [structural motif]
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