Format

Send to:

Choose Destination
    • Showing Current items.

    NME5 NME/NM23 family member 5 [ Homo sapiens (human) ]

    Gene ID: 8382, updated on 15-Jun-2019

    Summary

    Official Symbol
    NME5provided by HGNC
    Official Full Name
    NME/NM23 family member 5provided by HGNC
    Primary source
    HGNC:HGNC:7853
    See related
    Ensembl:ENSG00000112981 MIM:603575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NM23H5; RSPH23; NM23-H5
    Expression
    Biased expression in testis (RPKM 15.2), kidney (RPKM 4.4) and 8 other tissues See more
    Orthologs

    Genomic context

    See NME5 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (138115172..138139471, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137450861..137475132, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1148, pseudogene Neighboring gene Wnt family member 8A Neighboring gene RNA, U6 small nuclear 460, pseudogene Neighboring gene RNA, U6 small nuclear 888, pseudogene Neighboring gene bromodomain containing 8 Neighboring gene Sharpr-MPRA regulatory region 11877 Neighboring gene kinesin family member 20A Neighboring gene cell division cycle 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cilium movement IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoside diphosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoside metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spermatogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    ventricular system development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nucleoside diphosphate kinase homolog 5
    Names
    IPIA-beta
    NDK-H 5
    NDP kinase homolog 5
    inhibitor of p53-induced apoptosis-beta
    non-metastatic cells 5 protein expressed in
    non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)
    radial spoke 23 homolog
    testis-specific nm23 homolog
    NP_003542.1
    XP_005272156.1
    XP_016865434.1
    XP_024301995.1
    XP_024301996.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003551.3NP_003542.1  nucleoside diphosphate kinase homolog 5

      See identical proteins and their annotated locations for NP_003542.1

      Status: VALIDATED

      Source sequence(s)
      AF067724, BC026182, BM979998, BX490554
      Consensus CDS
      CCDS4197.1
      UniProtKB/Swiss-Prot
      P56597
      UniProtKB/TrEMBL
      A0A0S2Z4L9
      Related
      ENSP00000265191.2, ENST00000265191.4
      Conserved Domains (2) summary
      cd04418
      Location:13144
      NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...
      pfam05186
      Location:156197
      Dpy-30; Dpy-30 motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      138115175..138139471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446228.1XP_024301996.1  nucleoside diphosphate kinase homolog 5 isoform X2

      Conserved Domains (1) summary
      cd04418
      Location:13144
      NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...
    2. XM_017009945.2XP_016865434.1  nucleoside diphosphate kinase homolog 5 isoform X1

      Conserved Domains (2) summary
      cd04418
      Location:13144
      NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...
      pfam05186
      Location:156187
      Dpy-30; Dpy-30 motif
    3. XM_024446227.1XP_024301995.1  nucleoside diphosphate kinase homolog 5 isoform X1

      Conserved Domains (2) summary
      cd04418
      Location:13144
      NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...
      pfam05186
      Location:156187
      Dpy-30; Dpy-30 motif
    4. XM_005272099.2XP_005272156.1  nucleoside diphosphate kinase homolog 5 isoform X3

      Conserved Domains (2) summary
      smart00562
      Location:13148
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04418
      Location:13144
      NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...
    Support Center