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    KRTAP4-12 keratin associated protein 4-12 [ Homo sapiens (human) ]

    Gene ID: 83755, updated on 8-Nov-2023

    Summary

    Official Symbol
    KRTAP4-12provided by HGNC
    Official Full Name
    keratin associated protein 4-12provided by HGNC
    Primary source
    HGNC:HGNC:16776
    See related
    Ensembl:ENSG00000213416 AllianceGenome:HGNC:16776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAP4.12; KRTAP4.12
    Summary
    This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]
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    Genomic context

    See KRTAP4-12 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41123091..41124182, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41987947..41989038, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39279343..39280434, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904002 Neighboring gene keratin associated protein 4-11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39279561-39280114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39295928-39296440 Neighboring gene keratin associated protein 4-6 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:39300532-39300634 Neighboring gene keratin associated protein 4-5

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin-associated protein 4-12
    Names
    keratin-associated protein 4.12
    ultrahigh sulfur keratin-associated protein 4.12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031854.3NP_114060.1  keratin-associated protein 4-12

      See identical proteins and their annotated locations for NP_114060.1

      Status: REVIEWED

      Source sequence(s)
      AC100808
      Consensus CDS
      CCDS32649.1
      UniProtKB/Swiss-Prot
      A3KMC5, Q495I0, Q9BQ66
      Related
      ENSP00000377582.1, ENST00000394014.2
      Conserved Domains (1) summary
      cl26067
      Location:15180
      Keratin_B2; Keratin, high sulfur B2 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      41123091..41124182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791801.1 Reference GRCh38.p14 PATCHES

      Range
      72881..73972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003871091.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      272827..273918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      41987947..41989038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)