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    RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 [ Homo sapiens (human) ]

    Gene ID: 83695, updated on 18-Sep-2024

    Summary

    Official Symbol
    RHNO1provided by HGNC
    Official Full Name
    RAD9-HUS1-RAD1 interacting nuclear orphan 1provided by HGNC
    Primary source
    HGNC:HGNC:28206
    See related
    Ensembl:ENSG00000171792 MIM:614085; AllianceGenome:HGNC:28206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RHINO; C12orf32; HKMT1188
    Summary
    Involved in cellular response to radiation; recombinational repair; and regulation of cell cycle process. Located in chromosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.6), lymph node (RPKM 7.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RHNO1 in Genome Data Viewer
    Location:
    12p13.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (2876265..2889524)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (2882276..2895466)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (2985431..2998690)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 8339 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2943338-2943882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2943883-2944427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2944428-2944971 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2953993-2954980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:2954981-2955966 Neighboring gene testis expressed 52 Neighboring gene forkhead box M1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:2988229-2989182 Neighboring gene uncharacterized LOC124902860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4136 Neighboring gene TUB like protein 3 Neighboring gene Sharpr-MPRA regulatory region 7040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:3032139-3032645 Neighboring gene U7 small nuclear RNA Neighboring gene RNA, U6 small nuclear 1315, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: TULP3

    Clone Names

    • FLJ60873, MGC13204

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin-protein adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RAD9, HUS1, RAD1-interacting nuclear orphan protein 1
    Names
    Rad9, Rad1, Hus1 interacting nuclear orphan
    rAD9, RAD1, HUS1-interacting nuclear orphan protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252499.3NP_001239428.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001239428.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 4 and 5 all encode isoform 1.
      Source sequence(s)
      AB073599, AI631627
      Consensus CDS
      CCDS8518.1
      UniProtKB/Swiss-Prot
      B7Z989, Q9BSD3
      Related
      ENSP00000438590.1, ENST00000489288.7
      Conserved Domains (1) summary
      pfam15319
      Location:1236
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein
    2. NM_001252500.3NP_001239429.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001239429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AB073599, AI631627, AK304613
      Consensus CDS
      CCDS58199.1
      UniProtKB/Swiss-Prot
      Q9BSD3
      Related
      ENSP00000438828.1, ENST00000461997.5
      Conserved Domains (1) summary
      pfam15319
      Location:1222
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein
    3. NM_001257097.2NP_001244026.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001244026.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 all encode isoform 1.
      Source sequence(s)
      AB073599, AI631627, DA749974
      Consensus CDS
      CCDS8518.1
      UniProtKB/Swiss-Prot
      B7Z989, Q9BSD3
      Related
      ENSP00000479598.1, ENST00000618250.4
      Conserved Domains (1) summary
      pfam15319
      Location:1236
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein
    4. NM_001257098.2NP_001244027.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001244027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 all encode isoform 1.
      Source sequence(s)
      AB073599, AI631627, DA679606
      Consensus CDS
      CCDS8518.1
      UniProtKB/Swiss-Prot
      B7Z989, Q9BSD3
      Conserved Domains (1) summary
      pfam15319
      Location:1236
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

    RNA

    1. NR_027365.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the coding region, including the translational start codon, as found in variant 1.
      Source sequence(s)
      AI631627, AK021945
      Related
      ENST00000464682.2
    2. NR_046432.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB073599, AC005911, AI631627, DA378594
    3. NR_046433.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) uses an alternate 5' exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a significant portion of the coding region, including the translational start codon, as found in variant 1.
      Source sequence(s)
      AI631627, AK021945, BM847461

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      2876265..2889524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      2882276..2895466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)