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    TEKT1 tektin 1 [ Homo sapiens (human) ]

    Gene ID: 83659, updated on 17-Jun-2024

    Summary

    Official Symbol
    TEKT1provided by HGNC
    Official Full Name
    tektin 1provided by HGNC
    Primary source
    HGNC:HGNC:15534
    See related
    Ensembl:ENSG00000167858 MIM:609002; AllianceGenome:HGNC:15534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 17.1) See more
    Orthologs
    NEW
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    Genomic context

    See TEKT1 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (6797993..6831729, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (6698681..6732423, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (6701312..6735048, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903905 Neighboring gene XIAP associated factor 1 Neighboring gene F-box protein 39 Neighboring gene GATA motif-containing MPRA enhancer 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8079 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:6757097-6758296 Neighboring gene arachidonate 12-lipoxygenase pseudogene 2 Neighboring gene uncharacterized LOC124903907 Neighboring gene uncharacterized LOC124903908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6796999-6797500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:6797501-6798000

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in axonemal A tubule inner sheath IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axonemal microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053285.2NP_444515.1  tektin-1

      See identical proteins and their annotated locations for NP_444515.1

      Status: REVIEWED

      Source sequence(s)
      AC034305, BC014599
      Consensus CDS
      CCDS11083.1
      UniProtKB/Swiss-Prot
      D3DTM7, Q969V4
      UniProtKB/TrEMBL
      A8K9V3
      Related
      ENSP00000341346.2, ENST00000338694.7
      Conserved Domains (1) summary
      pfam03148
      Location:16395
      Tektin; Tektin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      6797993..6831729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524027.4XP_011522329.1  tektin-1 isoform X1

      Conserved Domains (1) summary
      pfam03148
      Location:16286
      Tektin; Tektin family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      6698681..6732423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317472.1XP_054173447.1  tektin-1 isoform X1