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    FAM107B family with sequence similarity 107 member B [ Homo sapiens (human) ]

    Gene ID: 83641, updated on 17-Jun-2019

    Summary

    Official Symbol
    FAM107Bprovided by HGNC
    Official Full Name
    family with sequence similarity 107 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:23726
    See related
    Ensembl:ENSG00000065809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HITS; C10orf45
    Expression
    Ubiquitous expression in lymph node (RPKM 45.0), kidney (RPKM 31.4) and 23 other tissues See more
    Orthologs

    Genomic context

    See FAM107B in Genome Data Viewer
    Location:
    10p13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (14518557..14774897, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (14560556..14816896, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene microRNA 1265 Neighboring gene MIR1265-FAM107B intergenic CAGE-defined T cell enhancer Neighboring gene uncharacterized LOC105376429 Neighboring gene uncharacterized LOC105376428 Neighboring gene RNA, 5S ribosomal pseudogene 302 Neighboring gene ribosomal protein SA pseudogene 7 Neighboring gene zinc finger and SCAN domain containing 29 pseudogene Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene heat shock protein family A (Hsp70) member 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ45505, MGC11034, MGC90261

    General protein information

    Preferred Names
    protein FAM107B
    Names
    FAM107B/CDNF fusion
    heat shock-inducible tumor small protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282695.1NP_001269624.1  protein FAM107B isoform a

      See identical proteins and their annotated locations for NP_001269624.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1 and 3 through 10 encode the same isoform (a).
      Source sequence(s)
      AK127413, AL136885, BC144707
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    2. NM_001282696.2NP_001269625.1  protein FAM107B isoform a

      See identical proteins and their annotated locations for NP_001269625.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
      Source sequence(s)
      AL136885, BC072452
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000367728.4, ENST00000378467.8
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    3. NM_001282697.2NP_001269626.1  protein FAM107B isoform a

      See identical proteins and their annotated locations for NP_001269626.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
      Source sequence(s)
      AL136885, BC072452, DA543225
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000418120.1, ENST00000468747.5
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    4. NM_001282698.2NP_001269627.1  protein FAM107B isoform a

      See identical proteins and their annotated locations for NP_001269627.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
      Source sequence(s)
      AK289959, AL136885
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000367719.2, ENST00000378458.6
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    5. NM_001282699.1NP_001269628.1  protein FAM107B isoform a

      See identical proteins and their annotated locations for NP_001269628.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
      Source sequence(s)
      AK289959, AL136885, DA390740, DC327230
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000479842.1, ENST00000622567.4
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    6. NM_001282700.2NP_001269629.1  protein FAM107B isoform a

      See identical proteins and their annotated locations for NP_001269629.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
      Source sequence(s)
      AL136885, AL157706, DA813465, DA954468
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000419603.1, ENST00000479731.5
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    7. NM_001282701.2NP_001269630.1  protein FAM107B isoform a

      See identical proteins and their annotated locations for NP_001269630.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
      Source sequence(s)
      AL136885, DA409460
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000367726.3, ENST00000378465.7
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    8. NM_001282702.2NP_001269631.1  protein FAM107B isoform a

      See identical proteins and their annotated locations for NP_001269631.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
      Source sequence(s)
      AL136885, DA305421
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    9. NM_001282703.1NP_001269632.1  protein FAM107B isoform a

      See identical proteins and their annotated locations for NP_001269632.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 3 through 10 encode the same isoform (a).
      Source sequence(s)
      AK289959, AL136885, DA269906, DC327230
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000367723.1, ENST00000378462.5
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    10. NM_001320735.2NP_001307664.1  protein FAM107B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
      Source sequence(s)
      AL136885, AL157706, DA954468, DB198416
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000420444.1, ENST00000468492.5
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    11. NM_001320736.2NP_001307665.1  protein FAM107B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
      Source sequence(s)
      AL136885, DA962195, DC327230
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    12. NM_001320737.1NP_001307666.1  protein FAM107B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
      Source sequence(s)
      AL136885, DA340804, DC332216
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    13. NM_001320738.1NP_001307667.1  protein FAM107B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
      Source sequence(s)
      AL136885, DB194372, DB240036
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    14. NM_001320739.2NP_001307668.1  protein FAM107B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
      Source sequence(s)
      AL136885, BF979432
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000367731.1, ENST00000378470.5
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    15. NM_001320740.1NP_001307669.1  protein FAM107B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) differs in the 5' UTR compared to variant 1. Variants 1 and 3-16 encode the same isoform (a).
      Source sequence(s)
      AL136885, DA116139
      Consensus CDS
      CCDS60486.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000420249.1, ENST00000489100.5
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    16. NM_001320741.2NP_001307670.1  protein FAM107B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) differs in the 5' UTR and contains a novel 5' coding region compared to variant 1. The encoded isoform (c) has a longer and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL136885, AL157706, DA922675
      UniProtKB/Swiss-Prot
      Q9H098
      Conserved Domains (1) summary
      pfam06625
      Location:47159
      DUF1151; Protein of unknown function (DUF1151)
    17. NM_031453.3NP_113641.2  protein FAM107B isoform b

      See identical proteins and their annotated locations for NP_113641.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
      Source sequence(s)
      AK127413, AL136885
      Consensus CDS
      CCDS7102.1
      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000181796.2, ENST00000181796.6
      Conserved Domains (1) summary
      pfam06625
      Location:183295
      DUF1151; Protein of unknown function (DUF1151)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      14518557..14774897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519735.1XP_011518037.1  protein FAM107B isoform X1

      See identical proteins and their annotated locations for XP_011518037.1

      UniProtKB/Swiss-Prot
      Q9H098
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    2. XM_017016749.1XP_016872238.1  protein FAM107B isoform X1

      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000417782.1, ENST00000478076.5
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
    3. XM_005252616.4XP_005252673.1  protein FAM107B isoform X1

      See identical proteins and their annotated locations for XP_005252673.1

      UniProtKB/Swiss-Prot
      Q9H098
      Related
      ENSP00000418330.1, ENST00000496330.5
      Conserved Domains (1) summary
      pfam06625
      Location:9120
      DUF1151; Protein of unknown function (DUF1151)
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