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    CASP3 caspase 3 [ Homo sapiens (human) ]

    Gene ID: 836, updated on 5-May-2024

    Summary

    Official Symbol
    CASP3provided by HGNC
    Official Full Name
    caspase 3provided by HGNC
    Primary source
    HGNC:HGNC:1504
    See related
    Ensembl:ENSG00000164305 MIM:600636; AllianceGenome:HGNC:1504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPP32; SCA-1; CPP32B
    Summary
    The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
    Expression
    Ubiquitous expression in duodenum (RPKM 26.8), small intestine (RPKM 21.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CASP3 in Genome Data Viewer
    Location:
    4q35.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (184627696..184649447, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (187971378..187993131, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (185548850..185570601, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene GAR1 ribonucleoprotein homolog (yeast) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22231 Neighboring gene Sharpr-MPRA regulatory region 13226 Neighboring gene long intergenic non-protein coding RNA 2365 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:185537732-185538289 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:185539175-185539674 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:185546799-185547380 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:185564061-185564639 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:185564640-185565217 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:185565519-185566150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15841 Neighboring gene primase and DNA directed polymerase Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:185609328-185610527 Neighboring gene centromere protein U Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15842 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:185654690-185655556 Neighboring gene NANOG hESC enhancer GRCh37_chr4:185657064-185657583 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:185668497-185668998 Neighboring gene acyl-CoA synthetase long chain family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22233 Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    In vitro infection with HIV-1 subtype B activates caspase-3 in neuronal cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 Env gp120 upregulates Caspase-3 in SVGA cells PubMed
    env Mutational analysis shows that HIV-1 gp120 R476K and N425R are associated with the bystander apoptosis-inducing activity of Env glycoprotein through caspase 3 PubMed
    env Treatment of astrocytes with HIV-1 gp120 induces the cleavage of CASP3 as compared with untreated cells PubMed
    env HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells PubMed
    env HIV-1 R5-tropic Env-mediated apoptosis of bystander cells is dependent on both CCR5 expression levels and fusogenic activity of the Env glycoprotein through the mechanism of apoptosis involved caspase-3 activation and mitochondrial depolarization PubMed
    env Treatment of HIV-1 Env-pseudotyped virus-infected MDM cells with both soluble TRAIL and an agonistic anti-DR5 antibody AD5-10 induces activation of caspase-3, -8, and -9 PubMed
    env HIV-1 gp120-mediated activation of caspase 8 occurs in a p53 independent manner, while HIV-1 gp120-mediated activation of caspase 3 requires p53 PubMed
    env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
    env Inactivation of PKR has an inhibitory effect on gp120-induced caspase-3 activation PubMed
    env Gp120-mediated activation of caspase-3 is significantly reduced in cells pretreated with PDGF-B PubMed
    env The combinatorial toxicity of cocaine and gp120 is accompanied by an increase in both caspase-3 activity and expression of the proapoptotic protein Bax in HIV-associated neuropathological disorders PubMed
    env The cytolytic process that takes place between primary uninfected CD4+ T cells and HIV-1 infected or HIV-1 gp120-expressing cells requires the activity of caspases such as ICE and CPP32 PubMed
    env The interaction of cell-associated HIV-1 gp120 with CXCR4-expressing target cells triggers apoptotic processes by activating caspase-9 and -3 PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    env Signal transducer and activator of transcription factor 1 (STAT1) partially regulates HIV-1 gp120/HCV E2-induced caspase 3 activity PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 Env from Yu-2 and primary isolates activate Caspase-3 and Caspase-7 in bystander cells of co-culture assays PubMed
    env HIV-1 gp120- and gp160-induced apoptosis in cell cultures through binding to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and pro-apoptotic molecule Bax PubMed
    env HIV-1 R5-tropic Env-mediated apoptosis of bystander cells is dependent on both CCR5 expression levels and fusogenic activity of the Env glycoprotein through the mechanism of apoptosis involved caspase-3 activation and mitochondrial depolarization PubMed
    env Induction of apoptosis in cell cultures through binding of HIV-1 gp120 or gp160 to CXCR4 involves protein kinase C, basic fibroblast growth factor, caspase-3, and the pro-apoptotic molecule Bax PubMed
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp120/41 Envelope proteins form a complex with integrin alpha4beta7 and chemokine receptor CCR5 on the CD4-negative gamma-delta T cell membrane, which leads to activation of the p38-caspase pathway and induces the death of gamma-delta cells PubMed
    env HIV-1 gp41-dependent apoptosis involves caspase-3-dependent mitochondrial depolarization and reactive oxygen species production; HIV-1 gp41-induced mitochondrial depolarization is inhibited by the protease inhibitor nelfinavir PubMed
    env HIV-1 R5-tropic Env-mediated apoptosis of bystander cells is dependent on both CCR5 expression levels and fusogenic activity of the Env glycoprotein through the mechanism of apoptosis involved caspase-3 activation and mitochondrial depolarization PubMed
    env Siva-1 sensitizes CD4-positive T-cells to HIV-1 gp120/gp41-induced apoptosis. The Siva-1-mediated sensitization on CD4-positive T-cells shows significant activation of caspase-3, -8, and -9 PubMed
    env A point mutation (V38E) in the gp41 region of HIV-1 abolishes HIV-1-mediated apoptosis by CASP3 and minimizes CD4 loss in humanized mice without altering viral replication PubMed
    Nef nef Stable expression of HIV-1 Nef in CEM T cells activates caspase-3 and enhances apoptosis through mechanisms unrelated to Fas PubMed
    nef Stable expression of HIV-1 Nef in Jurkat T cells confers resistance to Fas-mediated apoptosis through inactivation of caspase-3 and caspase-8 PubMed
    nef Microarray and Western blot analyses have shown HIV-1 Nef-induced apoptosis in human brain micro vascular endothelial cells requires the involvement of caspase-3 and caspase-9 PubMed
    Pr55(Gag) gag Monocyte-derived macrophages selectively capture and engulf HIV-1-infected CD4+ T cells as HIV-1 Gag interacts with CD3 and Caspase 3 markers, leading to efficient macrophage infection PubMed
    Tat tat HIV-1 clade B and C Tat induce cleavage of both PARP and CASP3 in primary glia PubMed
    tat CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells PubMed
    tat FasL-induced activation of caspase-3 and -8 proteins is inhibited in HIV-1 Tat101-expressing Jurkat cells PubMed
    tat HIV-1 Tat induces apoptosis through activation of caspase-3 PubMed
    tat The levels of caspase-3 protein are reduced after Caco-2 cells exposure to HIV-1 Tat compared with control PubMed
    tat PDGF-BB prevents caspase-3 activation induced by HIV-1 Tat and morphine in neuroblastoma cells PubMed
    tat Tat-triggered PKCdelta and PKCtheta activation results in the downstream signaling through the apoptosis pathways mediated by both ERK1/2 and caspase-3 PubMed
    tat Co-administration of morphine and HIV-1 Tat significantly increases the percentage of neurons expressing active caspase-3 PubMed
    tat HIV-1 Tat-induced apoptosis through increased expression of anti-apoptotic protein Bcl-2, proapoptotic protein Bax and activation of caspases CASP3 and CASP9 is inhibited by estrogen receptor beta (ER)-mediated estrogen treatment PubMed
    tat A p53 fusion protein with the HIV-1 Tat basic domain at its N terminus activates the expression of p21and downregulates the levels of caspase-3 and Bcl-2 PubMed
    Vpr vpr Visualization of HIV-1 Vpr-induced cell cycle arrest in G2 phase and apoptosis in HeLa/Fucci2 cells is associated with caspase-3 activation PubMed
    vpr Through activation of the caspase 9 pathway, HIV-1 Vpr also activates caspase 3 PubMed
    vpr Induction of G2 cell cycle arrest by Vpr is upregulated under caspase 3-inhibition and induction of apoptosis by Vpr is downregulated by caspase 3-inhibition PubMed
    vpr Inhibition of caspase 3 by compound Z-DEVD-fmk causes accumulation of HIV-1 Vpr at the nuclear envelope. VprL23F and VprP35A mutants abrogate the sensitivity to caspase 3-inhibition PubMed
    vpr HIV-1 Vpr increases the activity of caspase-3 and caspase-9, but not of caspase-8 in human HeLa cells; Vpr-induced apoptosis can be inhibited by inhibitors of caspase-3 and caspase-9, but not by inhibitors of caspase-8 PubMed
    vpr HIV-1 Vpr-induced apoptosis results in caspase 3 cleavage PubMed
    vpr HIV-1 Vpr segments with mutation at the positions 70, 85, 86, or 94 show lower apoptosis-inducing capabilities by the attenuation of Caspase-3 activity PubMed
    vpr Virion-associated Vpr activates caspase 3/7, 8, and 9 in Fas-mediated apoptosis in Jurkat T cells and human activated PBMCs PubMed
    vpr Virion-associated Vpr triggers apoptosis through caspases 3/7 and 9 in human T cells independently of other HIV de novo-expressed proteins and also activates caspase 8, the initiator caspase of the death receptor pathway PubMed
    vpr HIV-1 Vpr-induced apoptosis through caspase activation and Smac release from mitochondria is dependent on G2 cell cycle arrest , but is lost in cells synchronized in G1/S PubMed
    vpr Overproduction of EEF2 blocks HIV-1 Vpr-induced cell death both in fission yeast and human cells, suppresses caspase 9 and caspase 3-mediated apoptosis induced by Vpr, and reduces cytochrome c release induced by Vpr PubMed
    Vpu vpu Caspase-8 and caspase-3 activity are required for HIV-1 Vpu-induced cleavage of IRF3 and HIV-1 infection also induces caspase-mediated IRF3 cleavage PubMed
    vpu Levels of active caspase-3 are elevated in T cells as a result of HIV-1 Vpu-mediated inhibition of NF-kappa B activation PubMed
    retropepsin gag-pol HIV-1 PR cleaves CASP3 to result in three processed products, Myr-lyn signal peptide, p17 and p12 proteins PubMed
    gag-pol HIV-1 protease directly cleaves and activates procaspase 8 in T cells which is associated with cleavage of BID, mitochondrial release of cytochrome c, activation of the downstream caspases 9 and 3, and cleavage of DFF and PARP PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables death receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase A2 activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axonal fasciculation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to staurosporine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in erythrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in erythrocyte differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in execution phase of apoptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fibroblast apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to osmotic stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in keratinocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in learning or memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in leukocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in luteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet formation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of amyloid-beta formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of pyroptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pyroptosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of macroautophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of protein stability IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to UV IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to X-ray IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amino acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cobalt ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to tumor necrosis factor TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    caspase-3
    Names
    CASP-3
    CPP-32
    PARP cleavage protease
    SREBP cleavage activity 1
    apopain
    caspase 3, apoptosis-related cysteine peptidase
    caspase 3, apoptosis-related cysteine protease
    cysteine protease CPP32
    procaspase3
    protein Yama
    NP_001341706.1
    NP_001341708.1
    NP_001341709.1
    NP_001341710.1
    NP_001341711.1
    NP_001341712.1
    NP_001341713.1
    NP_004337.2
    NP_116786.1
    XP_047272192.1
    XP_047272193.1
    XP_047272194.1
    XP_047272195.1
    XP_054206930.1
    XP_054206931.1
    XP_054206932.1
    XP_054206933.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001354777.2NP_001341706.1  caspase-3 isoform a preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC073932, AC079257
      Consensus CDS
      CCDS3836.1
      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2
      Conserved Domains (1) summary
      smart00115
      Location:37277
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    2. NM_001354779.2NP_001341708.1  caspase-3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform b.
      Source sequence(s)
      AC073932, AC079257
      Conserved Domains (1) summary
      smart00115
      Location:11251
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    3. NM_001354780.2NP_001341709.1  caspase-3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 5, encodes isoform b.
      Source sequence(s)
      AC073932, AC079257
      Conserved Domains (1) summary
      smart00115
      Location:11251
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    4. NM_001354781.2NP_001341710.1  caspase-3 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes isoform c.
      Source sequence(s)
      AC073932, AC079257
      Consensus CDS
      CCDS87283.1
      UniProtKB/TrEMBL
      A8MVM1
      Related
      ENSP00000377213.4, ENST00000393588.8
      Conserved Domains (1) summary
      cl00042
      Location:37161
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    5. NM_001354782.2NP_001341711.1  caspase-3 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes isoform c.
      Source sequence(s)
      AC073932, AC079257
      Consensus CDS
      CCDS87283.1
      UniProtKB/TrEMBL
      A8MVM1
      Related
      ENSP00000428372.1, ENST00000517513.5
      Conserved Domains (1) summary
      cl00042
      Location:37161
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    6. NM_001354783.2NP_001341712.1  caspase-3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC073932, AC079257
      UniProtKB/TrEMBL
      Q5HYI3
      Conserved Domains (1) summary
      cl00042
      Location:46170
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    7. NM_001354784.2NP_001341713.1  caspase-3 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC073932, AC079257
      Conserved Domains (1) summary
      cl00042
      Location:11135
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    8. NM_004346.4NP_004337.2  caspase-3 isoform a preproprotein

      See identical proteins and their annotated locations for NP_004337.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as alpha) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AU127028, BC016926, BU753483
      Consensus CDS
      CCDS3836.1
      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2
      Related
      ENSP00000311032.4, ENST00000308394.9
      Conserved Domains (1) summary
      smart00115
      Location:37277
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    9. NM_032991.3NP_116786.1  caspase-3 isoform a preproprotein

      See identical proteins and their annotated locations for NP_116786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as beta) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AU127028, BC016926, BU753483
      Consensus CDS
      CCDS3836.1
      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2
      Related
      ENSP00000428929.1, ENST00000523916.5
      Conserved Domains (1) summary
      smart00115
      Location:37277
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      184627696..184649447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416239.1XP_047272195.1  caspase-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2
    2. XM_047416237.1XP_047272193.1  caspase-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2
    3. XM_047416238.1XP_047272194.1  caspase-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2
    4. XM_047416236.1XP_047272192.1  caspase-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      187971378..187993131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350955.1XP_054206930.1  caspase-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2
    2. XM_054350956.1XP_054206931.1  caspase-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2
    3. XM_054350957.1XP_054206932.1  caspase-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2
    4. XM_054350958.1XP_054206933.1  caspase-3 isoform X1

      UniProtKB/Swiss-Prot
      A8K5M2, D3DP53, P42574, Q96AN1, Q96KP2