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    H4C1 H4 clustered histone 1 [ Homo sapiens (human) ]

    Gene ID: 8359, updated on 2-Nov-2024

    Summary

    Official Symbol
    H4C1provided by HGNC
    Official Full Name
    H4 clustered histone 1provided by HGNC
    Primary source
    HGNC:HGNC:4781
    See related
    Ensembl:ENSG00000278637 MIM:602822; AllianceGenome:HGNC:4781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4FA; H4-16; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16; HIST1H4A
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See H4C1 in Genome Data Viewer
    Location:
    6p22.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26021649..26022050)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (25887588..25887989)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26021877..26022278)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H1.1 linker histone, cluster member Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26020191-26021007 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26021008-26021824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26021825-26022640 Neighboring gene H3 clustered histone 1 Neighboring gene Sharpr-MPRA regulatory region 4264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24178 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:26027580-26028165 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26028166-26028750 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:26028751-26029336 Neighboring gene H4 clustered histone 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24180 Neighboring gene H3 clustered histone 2

    Genomic regions, transcripts, and products

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, histone H4, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H4
    Names
    H4 histone family, member A
    histone 1, H4a
    histone cluster 1 H4 family member a
    histone cluster 1, H4a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003538.4NP_003529.1  histone H4

      See identical proteins and their annotated locations for NP_003529.1

      Status: REVIEWED

      Source sequence(s)
      U91328
      Consensus CDS
      CCDS4571.1
      UniProtKB/Swiss-Prot
      A2VCL0, P02304, P02305, P62805, Q6DRA9, Q6FGB8, Q6NWP7
      UniProtKB/TrEMBL
      B2R4R0
      Related
      ENSP00000479106.2, ENST00000617569.2
      Conserved Domains (1) summary
      PLN00035
      Location:1103
      PLN00035; histone H4; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      26021649..26022050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      25887588..25887989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)