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    FCRL4 Fc receptor like 4 [ Homo sapiens (human) ]

    Gene ID: 83417, updated on 17-Jun-2019

    Summary

    Official Symbol
    FCRL4provided by HGNC
    Official Full Name
    Fc receptor like 4provided by HGNC
    Primary source
    HGNC:HGNC:18507
    See related
    Ensembl:ENSG00000163518 MIM:605876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FCRH4; IGFP2; IRTA1; CD307d
    Summary
    This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
    Expression
    Biased expression in lymph node (RPKM 2.4), appendix (RPKM 2.3) and 5 other tissues See more
    Orthologs

    Genomic context

    See FCRL4 in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (157573747..157598085, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157543539..157567870, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SLAM family member 5 Neighboring gene Fc receptor like 5 Neighboring gene uncharacterized LOC105371457 Neighboring gene Fc receptor like 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of B cells with HIV-1 gp120 upregulates the expression of FCRL4 and limits the proliferative expansion of B cells in an integrin alpha 4/beta 7-dependent manner PubMed
    env HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC150522, MGC150523

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Fc receptor-like protein 4
    Names
    IFGP family protein 2
    fc receptor homolog 4
    fcR-like protein 4
    hIFGP2
    immune receptor translocation-associated protein 1
    immunoglobulin superfamily Fc receptor, gp42
    immunoglobulin superfamily receptor translocation associated 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031282.3NP_112572.1  Fc receptor-like protein 4 precursor

      See identical proteins and their annotated locations for NP_112572.1

      Status: REVIEWED

      Source sequence(s)
      AF343659, AF343661, AL135929
      Consensus CDS
      CCDS1166.1
      UniProtKB/Swiss-Prot
      Q96PJ5
      Related
      ENSP00000271532.1, ENST00000271532.2
      Conserved Domains (4) summary
      cd05752
      Location:23100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:295377
      IG_like; Immunoglobulin like
      pfam13895
      Location:193281
      Ig_2; Immunoglobulin domain
      cd05753
      Location:105188
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      157573747..157598085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510034.1XP_011508336.1  Fc receptor-like protein 4 isoform X1

      Conserved Domains (5) summary
      cd05752
      Location:2299
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:294376
      IG_like; Immunoglobulin like
      pfam00047
      Location:301369
      ig; Immunoglobulin domain
      pfam13927
      Location:192264
      Ig_3; Immunoglobulin domain
      cl11960
      Location:104170
      Ig; Immunoglobulin domain
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