U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    H3-4 H3.4 histone, cluster member [ Homo sapiens (human) ]

    Gene ID: 8290, updated on 6-Oct-2024

    Summary

    Official Symbol
    H3-4provided by HGNC
    Official Full Name
    H3.4 histone, cluster memberprovided by HGNC
    Primary source
    HGNC:HGNC:4778
    See related
    Ensembl:ENSG00000168148 MIM:602820; AllianceGenome:HGNC:4778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H3t; H3.4; H3/g; H3FT; H3C16; HIST3H3
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See H3-4 in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228424845..228425360, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227613357..227613872, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228612546..228613061, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228587477-228588152 Neighboring gene microRNA 6742 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228589505-228590179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228595439-228596098 Neighboring gene uncharacterized LOC124904537 Neighboring gene tripartite motif containing 17 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1920 Neighboring gene uncharacterized LOC124904538 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:228628090-228628374 Neighboring gene ribosomal protein L23a pseudogene 15

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev co-localizes with histone H3 in the nucleoplasmic compartment of cells PubMed
    Tat tat Phosphorylation of serine 10 in histone H3 at the HIV promoter is increased in the presence of HIV-1 Tat PubMed
    tat Purified recombinant Tat and Tat-derived synthetic peptides derived from the p300- and PCAF-binding sites in Tat inhibit histone H3/H4 acetylation in vitro PubMed
    tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126886, MGC126888

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nucleosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H3.1t
    Names
    H3 clustered histone 16
    H3 histone family, member T
    H3.4 histone
    H3/t
    histone 3, H3
    histone H3.4
    histone cluster 3 H3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003493.3NP_003484.1  histone H3.1t

      See identical proteins and their annotated locations for NP_003484.1

      Status: REVIEWED

      Source sequence(s)
      AL139288
      Consensus CDS
      CCDS1572.1
      UniProtKB/Swiss-Prot
      B2R5K3, Q16695, Q6FGU4
      UniProtKB/TrEMBL
      A8K4Y7, B2R6Y1
      Related
      ENSP00000355657.2, ENST00000366696.2
      Conserved Domains (1) summary
      PTZ00018
      Location:1136
      PTZ00018; histone H3; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      228424845..228425360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654708.1 Reference GRCh38.p14 PATCHES

      Range
      16044..16559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      227613357..227613872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)