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    NUAK2 NUAK family kinase 2 [ Homo sapiens (human) ]

    Gene ID: 81788, updated on 13-Feb-2019

    Summary

    Official Symbol
    NUAK2provided by HGNC
    Official Full Name
    NUAK family kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:29558
    See related
    Ensembl:ENSG00000163545 MIM:608131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNARK
    Expression
    Broad expression in esophagus (RPKM 10.7), kidney (RPKM 9.5) and 22 other tissues See more
    Orthologs

    Genomic context

    See NUAK2 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (205302059..205321791, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (205271191..205290883, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dual serine/threonine and tyrosine protein kinase Neighboring gene ribosomal protein L17 pseudogene 8 Neighboring gene uncharacterized LOC101929459 Neighboring gene transmembrane and coiled-coil domain family 2 Neighboring gene kelch domain containing 8A Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 10 Neighboring gene uncharacterized LOC105371698 Neighboring gene LEMD1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ90349, DKFZp434J037, DKFZp686F01113

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    NUAK family SNF1-like kinase 2
    Names
    NUAK family, SNF1-like kinase, 2
    SNF1/AMP activated protein kinase
    SNF1/AMP kinase-related kinase
    omphalocele kinase 2
    XP_005245572.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030952.3NP_112214.3  NUAK family SNF1-like kinase 2

      Status: VALIDATED

      Source sequence(s)
      AC098933
      Consensus CDS
      CCDS1453.2
      Related
      ENSP00000356125.4, ENST00000367157.4

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      205302059..205321791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245515.4XP_005245572.1  NUAK family SNF1-like kinase 2 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:156
      PKc_like; Protein Kinases, catalytic domain
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