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    TRIM11 tripartite motif containing 11 [ Homo sapiens (human) ]

    Gene ID: 81559, updated on 17-Jun-2019

    Summary

    Official Symbol
    TRIM11provided by HGNC
    Official Full Name
    tripartite motif containing 11provided by HGNC
    Primary source
    HGNC:HGNC:16281
    See related
    Ensembl:ENSG00000154370 MIM:607868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BIA1; RNF92
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 7.7), spleen (RPKM 6.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See TRIM11 in Genome Data Viewer
    Location:
    1q42.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (228393672..228406835, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228581373..228594584, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene Sharpr-MPRA regulatory region 4086 Neighboring gene uncharacterized LOC101927401 Neighboring gene microRNA 6742 Neighboring gene tripartite motif containing 17 Neighboring gene histone cluster 3 H3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 infection is modestly restricted by human TRIM11 and downregulation of TRIM11 enhances virus release, suggesting the interaction between HIV-1 Gag and TRIM11 PubMed
    Vpr vpr HIV-1 Vpr may indirectly regulate TRIM11 in a dose-dependent manner, which is independent of the ubiquitin system or VprBP-mediated pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of viral release from host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of viral release from host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of viral transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM11
    Names
    RING finger protein 92
    RING-type E3 ubiquitin transferase TRIM11
    tripartite motif-containing protein 11
    NP_660215.1
    XP_011542587.1
    XP_016857901.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145214.3NP_660215.1  E3 ubiquitin-protein ligase TRIM11

      See identical proteins and their annotated locations for NP_660215.1

      Status: REVIEWED

      Source sequence(s)
      AL670729
      Consensus CDS
      CCDS31048.1
      UniProtKB/Swiss-Prot
      Q96F44
      Related
      ENSP00000284551.6, ENST00000284551.11
      Conserved Domains (3) summary
      cd15811
      Location:288456
      SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)
      pfam00643
      Location:87128
      zf-B_box; B-box zinc finger
      cd16594
      Location:1357
      RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      228393672..228406835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544285.3XP_011542587.1  E3 ubiquitin-protein ligase TRIM11 isoform X2

      Conserved Domains (3) summary
      pfam00643
      Location:87128
      zf-B_box; B-box zinc finger
      pfam15227
      Location:1656
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd15811
      Location:211379
      SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)
    2. XM_017002412.2XP_016857901.1  E3 ubiquitin-protein ligase TRIM11 isoform X1

      UniProtKB/Swiss-Prot
      Q96F44
      Conserved Domains (3) summary
      pfam00643
      Location:87128
      zf-B_box; B-box zinc finger
      pfam15227
      Location:1656
      zf-C3HC4_4; zinc finger of C3HC4-type, RING
      cd15811
      Location:287455
      SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)
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