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    TAS1R1 taste 1 receptor member 1 [ Homo sapiens (human) ]

    Gene ID: 80835, updated on 11-Sep-2019

    Summary

    Official Symbol
    TAS1R1provided by HGNC
    Official Full Name
    taste 1 receptor member 1provided by HGNC
    Primary source
    HGNC:HGNC:14448
    See related
    Ensembl:ENSG00000173662 MIM:606225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TR1; T1R1; GM148; GPR70
    Summary
    The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
    Expression
    Biased expression in testis (RPKM 1.2), gall bladder (RPKM 0.1) and 7 other tissues See more
    Orthologs

    Genomic context

    See TAS1R1 in Genome Data Viewer
    Location:
    1p36.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (6555307..6579755)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6614987..6639817)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TNF receptor superfamily member 25 Neighboring gene pleckstrin homology and RhoGEF domain containing G5 Neighboring gene nucleolar protein 9 Neighboring gene RNA, U6 small nuclear 731, pseudogene Neighboring gene uncharacterized LOC107984912 Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene kelch like family member 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem (from REACTOME)
      Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystemThe class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). ...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Taste transduction, organism-specific biosystem (from KEGG)
      Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
    • Taste transduction, conserved biosystem (from KEGG)
      Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterodimerization activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    taste receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    detection of chemical stimulus involved in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of umami taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sensory perception of umami taste IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IC
    Inferred by Curator
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    taste receptor type 1 member 1
    Names
    G-protein coupled receptor 70
    seven transmembrane helix receptor
    taste receptor, type 1, member 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138697.4NP_619642.2  taste receptor type 1 member 1 isoform b precursor

      See identical proteins and their annotated locations for NP_619642.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).
      Source sequence(s)
      AI742401, AL591866, BC136515, BC136516
      Consensus CDS
      CCDS81.1
      UniProtKB/Swiss-Prot
      Q7RTX1
      Related
      ENSP00000331867.6, ENST00000333172.11
      Conserved Domains (4) summary
      cd06363
      Location:32486
      PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
      pfam00003
      Location:588814
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:74457
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:495544
      NCD3G; Nine Cysteines Domain of family 3 GPCR
    2. NM_177540.3NP_803884.1  taste receptor type 1 member 1 isoform c precursor

      See identical proteins and their annotated locations for NP_803884.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 2, resulting in an isoform (c) which is shorter but has the same N- and C-termini compared to isoform b.
      Source sequence(s)
      AI742401, AK292014, AL591866, BC136515
      Consensus CDS
      CCDS82.1
      UniProtKB/Swiss-Prot
      Q7RTX1
      UniProtKB/TrEMBL
      A8K7J9
      Related
      ENSP00000312558.5, ENST00000351136.7
      Conserved Domains (3) summary
      pfam00003
      Location:334560
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam07562
      Location:241290
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:32166
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      6555307..6579755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542203.2XP_011540505.1  taste receptor type 1 member 1 isoform X2

      See identical proteins and their annotated locations for XP_011540505.1

      Conserved Domains (4) summary
      pfam00003
      Location:510736
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:1379
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:417466
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:1408
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    2. XM_017002402.1XP_016857891.1  taste receptor type 1 member 1 isoform X1

    3. XM_017002403.1XP_016857892.1  taste receptor type 1 member 1 isoform X3

    4. XM_011542206.2XP_011540508.1  taste receptor type 1 member 1 isoform X4

      Conserved Domains (3) summary
      cd06363
      Location:66488
      PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
      pfam01094
      Location:76459
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:497542
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177539.1: Suppressed sequence

      Description
      NM_177539.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_177541.1: Suppressed sequence

      Description
      NM_177541.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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