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    THAP7 THAP domain containing 7 [ Homo sapiens (human) ]

    Gene ID: 80764, updated on 15-Jun-2019

    Summary

    Official Symbol
    THAP7provided by HGNC
    Official Full Name
    THAP domain containing 7provided by HGNC
    Primary source
    HGNC:HGNC:23190
    See related
    Ensembl:ENSG00000184436 MIM:609518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in testis (RPKM 11.7), ovary (RPKM 8.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See THAP7 in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (20999772..21002115, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21354061..21356404, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene apoptosis inducing factor mitochondria associated 3 Neighboring gene leucine zipper like transcription regulator 1 Neighboring gene THAP7 antisense RNA 1 Neighboring gene tubulin alpha 3f pseudogene Neighboring gene purinergic receptor P2X 6 Neighboring gene solute carrier family 7 member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC10963

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C2H2 zinc finger domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    DNA-binding transcription factor activity, RNA polymerase II-specific ISM
    Inferred from Sequence Model
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    THAP domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008695.1NP_001008695.1  THAP domain-containing protein 7

      See identical proteins and their annotated locations for NP_001008695.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC004346, BE264280, BM790105
      Consensus CDS
      CCDS13787.1
      UniProtKB/Swiss-Prot
      Q9BT49
      Related
      ENSP00000382084.2, ENST00000399133.2
      Conserved Domains (1) summary
      smart00980
      Location:493
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
    2. NM_030573.3NP_085050.2  THAP domain-containing protein 7

      See identical proteins and their annotated locations for NP_085050.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC002470, AC002472, BC004346, BE264280, BM790105
      Consensus CDS
      CCDS13787.1
      UniProtKB/Swiss-Prot
      Q9BT49
      Related
      ENSP00000215742.4, ENST00000215742.8
      Conserved Domains (1) summary
      smart00980
      Location:493
      THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      20999104..21002118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008696.1: Suppressed sequence

      Description
      NM_001008696.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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