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    STAM signal transducing adaptor molecule [ Homo sapiens (human) ]

    Gene ID: 8027, updated on 3-Jun-2019

    Summary

    Official Symbol
    STAMprovided by HGNC
    Official Full Name
    signal transducing adaptor moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:11357
    See related
    Ensembl:ENSG00000136738 MIM:601899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STAM1; STAM-1
    Summary
    This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 7.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See STAM in Genome Data Viewer
    Location:
    10p12.33
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (17644125..17716824)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (17686124..17758823)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene STAM antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC107984212 Neighboring gene transmembrane protein 236 Neighboring gene mannose receptor C-type 1 Neighboring gene microRNA 511

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
    • Deubiquitination, organism-specific biosystem (from REACTOME)
      Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • EGFR downregulation, organism-specific biosystem (from REACTOME)
      EGFR downregulation, organism-specific biosystemRegulation of receptor tyrosine kinase (RTK) activity is implicated in the control of almost all cellular functions. One of the best understood RTKs is epidermal growth factor receptor (EGFR). Growth...
    • ESCRT-0 complex, organism-specific biosystem (from KEGG)
      ESCRT-0 complex, organism-specific biosystemStructural complex; Genetic information processing; Protein processing
    • ESCRT-0 complex, conserved biosystem (from KEGG)
      ESCRT-0 complex, conserved biosystemStructural complex; Genetic information processing; Protein processing
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem (from REACTOME)
      Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystemMany plasma membrane proteins are in a constant flux throughout the internal trafficking pathways of the cell. Some receptors are continuously internalized into recycling endosomes and returned to th...
    • IL2-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL2-mediated signaling events, organism-specific biosystem
      IL2-mediated signaling events
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • InlB-mediated entry of Listeria monocytogenes into host cell, organism-specific biosystem (from REACTOME)
      InlB-mediated entry of Listeria monocytogenes into host cell, organism-specific biosystemInlB, a cell wall protein of Listeria monocytogenes, binds MET receptor, acting as an HGF agonist (Shen et al. 2000, Veiga and Cossart 2005). Listeria monocytogenes InlB proteins dimerize through the...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Listeria monocytogenes entry into host cells, organism-specific biosystem (from REACTOME)
      Listeria monocytogenes entry into host cells, organism-specific biosystemListeria monocytogenes is a short, gram-positive, nonspore-forming motile rod. Serotypes 1/2a, 1/2b and 4b make up more than 95% of isolates from humans, with serotype 4b causing most of the food-bor...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Metalloprotease DUBs, organism-specific biosystem (from REACTOME)
      Metalloprotease DUBs, organism-specific biosystemThe JAB1/MPN +/MOV34 (JAMM) domain metalloproteases cleave the isopeptide bond at or near the the attachment point of polyubiquitin and substrate. PSMD14 (RPN11), STAMBP (AMSH), STAMBPL1 (AMSH-LP), a...
    • Negative regulation of MET activity, organism-specific biosystem (from REACTOME)
      Negative regulation of MET activity, organism-specific biosystemSignaling by MET receptor is negatively regulated mainly by MET receptor dephosphorylation or MET receptor degradation. Protein tyrosine phosphatase PTPRJ dephosphorylates MET tyrosine residue Y1349,...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by MET, organism-specific biosystem (from REACTOME)
      Signaling by MET, organism-specific biosystemMET is a receptor tyrosine kinase (RTK) (Cooper et al. 1984, Park et al. 1984) activated by binding to its ligand, Hepatocyte growth factor/Scatter factor (HGF/SF) (Bottaro et al. 1991, Naldini et al...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686J2352

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3/SH2 adaptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    endosomal transport TAS
    Traceable Author Statement
    more info
     
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    macroautophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane organization TAS
    Traceable Author Statement
    more info
     
    multivesicular body assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of exosomal secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    protein deubiquitination TAS
    Traceable Author Statement
    more info
     
    regulation of extracellular exosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    ESCRT-0 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ESCRT-0 complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    signal transducing adapter molecule 1
    Names
    HSE1 homolog
    signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324282.2NP_001311211.1  signal transducing adapter molecule 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC069542
    2. NM_001324283.2NP_001311212.1  signal transducing adapter molecule 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
      Source sequence(s)
      AC069542
      Conserved Domains (3) summary
      cd11964
      Location:163217
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      pfam03127
      Location:256327
      GAT; GAT domain
      cl02544
      Location:192
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    3. NM_001324284.2NP_001311213.1  signal transducing adapter molecule 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
      Source sequence(s)
      AC069542
      Conserved Domains (3) summary
      cd11964
      Location:163217
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      pfam03127
      Location:256327
      GAT; GAT domain
      cl02544
      Location:192
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    4. NM_001324285.2NP_001311214.1  signal transducing adapter molecule 1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
      Source sequence(s)
      AC069542
      Conserved Domains (3) summary
      cd11964
      Location:163217
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      pfam03127
      Location:256327
      GAT; GAT domain
      cl02544
      Location:192
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    5. NM_001324286.2NP_001311215.1  signal transducing adapter molecule 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC069542
    6. NM_001324287.2NP_001311216.1  signal transducing adapter molecule 1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC069542
      UniProtKB/TrEMBL
      B4DZT2
      Conserved Domains (3) summary
      cd11964
      Location:102156
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      pfam03127
      Location:195266
      GAT; GAT domain
      cl02544
      Location:131
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    7. NM_001324288.2NP_001311217.1  signal transducing adapter molecule 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) and variant 9 both encode isoform f.
      Source sequence(s)
      AC069542
    8. NM_001324289.2NP_001311218.1  signal transducing adapter molecule 1 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) and variant 8 both encode isoform f.
      Source sequence(s)
      AC069542
    9. NM_003473.4NP_003464.1  signal transducing adapter molecule 1 isoform a

      See identical proteins and their annotated locations for NP_003464.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC069542, AU118708, U43899
      Consensus CDS
      CCDS7122.1
      UniProtKB/Swiss-Prot
      Q92783
      Related
      ENSP00000366746.3, ENST00000377524.8
      Conserved Domains (3) summary
      cd11964
      Location:213267
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      cd03568
      Location:9142
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
      pfam03127
      Location:306377
      GAT; GAT domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      17644125..17716824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519695.3XP_011517997.1  signal transducing adapter molecule 1 isoform X1

      Conserved Domains (3) summary
      cd11964
      Location:213267
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      cd03568
      Location:9142
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
      pfam03127
      Location:306377
      GAT; GAT domain
    2. XM_017016685.2XP_016872174.1  signal transducing adapter molecule 1 isoform X2

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