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    MYO19 myosin XIX [ Homo sapiens (human) ]

    Gene ID: 80179, updated on 15-Jun-2019

    Summary

    Official Symbol
    MYO19provided by HGNC
    Official Full Name
    myosin XIXprovided by HGNC
    Primary source
    HGNC:HGNC:26234
    See related
    Ensembl:ENSG00000278259 MIM:617379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYOHD1
    Expression
    Ubiquitous expression in skin (RPKM 10.8), esophagus (RPKM 7.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See MYO19 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (36495636..36535457, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34851599..34891305, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371749 Neighboring gene RNA, 5S ribosomal pseudogene 439 Neighboring gene zinc finger HIT-type containing 3 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene gametogenetin binding protein 2 Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene dehydrogenase/reductase 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22865

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin light chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    plus-end directed microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    mitochondrion migration along actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myosin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    unconventional myosin-XIX
    Names
    myosin head domain containing 1
    myosin head domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033580.2NP_001028752.1  unconventional myosin-XIX isoform 3

      See identical proteins and their annotated locations for NP_001028752.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' coding region, 3' UTR, and poly-adenylation signal, compared to variant 2. The resulting isoform (3) has a substantially shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AA631248, AK026518, AK293903
      Consensus CDS
      CCDS59283.1
      UniProtKB/Swiss-Prot
      Q96H55
      UniProtKB/TrEMBL
      A0A024R0S9, B7Z1T7
      Related
      ENSP00000477559.1, ENST00000621344.4
      Conserved Domains (1) summary
      cl22853
      Location:49299
      Motor_domain; Myosin and Kinesin motor domain
    2. NM_001163735.1NP_001157207.1  unconventional myosin-XIX isoform 2

      See identical proteins and their annotated locations for NP_001157207.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AK293903, AK304073, BM661625
      Consensus CDS
      CCDS54112.1
      UniProtKB/Swiss-Prot
      Q96H55
      UniProtKB/TrEMBL
      B4E218, B7Z1T7
      Related
      ENSP00000479518.1, ENST00000614623.4
      Conserved Domains (2) summary
      smart00242
      Location:36754
      MYSc; Myosin. Large ATPases
      cd14880
      Location:49746
      MYSc_Myo19; class XIX myosin, motor domain
    3. NM_025109.5NP_079385.2  unconventional myosin-XIX isoform 1

      See identical proteins and their annotated locations for NP_079385.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame segment, compared to variant 2. The resulting isoform (1) lacks an internal segment in the central coding region, compared to isoform 2.
      Source sequence(s)
      AK293903, AK304073, BC008900
      Consensus CDS
      CCDS45654.1
      UniProtKB/Swiss-Prot
      Q96H55
      UniProtKB/TrEMBL
      B4E218, B7Z1T7
      Related
      ENSP00000478437.1, ENST00000610930.4
      Conserved Domains (1) summary
      cl22853
      Location:49439
      Motor_domain; Myosin and Kinesin motor domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      36495636..36535457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525290.3XP_011523592.1  unconventional myosin-XIX isoform X5

      See identical proteins and their annotated locations for XP_011523592.1

      Conserved Domains (2) summary
      smart00242
      Location:36785
      MYSc; Myosin. Large ATPases
      cd14880
      Location:49777
      MYSc_Myo19; class XIX myosin, motor domain
    2. XM_024450955.1XP_024306723.1  unconventional myosin-XIX isoform X1

      Conserved Domains (1) summary
      cd14880
      Location:49823
      MYSc_Myo19; class XIX myosin, motor domain
    3. XM_017025158.2XP_016880647.1  unconventional myosin-XIX isoform X3

      Conserved Domains (1) summary
      cd14880
      Location:49792
      MYSc_Myo19; class XIX myosin, motor domain
    4. XM_017025159.2XP_016880648.1  unconventional myosin-XIX isoform X4

    5. XM_011525287.2XP_011523589.1  unconventional myosin-XIX isoform X2

      See identical proteins and their annotated locations for XP_011523589.1

      Conserved Domains (2) summary
      smart00242
      Location:36829
      MYSc; Myosin. Large ATPases
      cd14880
      Location:49821
      MYSc_Myo19; class XIX myosin, motor domain
    6. XM_017025160.2XP_016880649.1  unconventional myosin-XIX isoform X6

    7. XM_011525286.2XP_011523588.1  unconventional myosin-XIX isoform X1

      See identical proteins and their annotated locations for XP_011523588.1

      Conserved Domains (1) summary
      cd14880
      Location:49823
      MYSc_Myo19; class XIX myosin, motor domain
    8. XM_017025161.2XP_016880650.1  unconventional myosin-XIX isoform X7

      Conserved Domains (1) summary
      cl22853
      Location:45630
      Motor_domain; Myosin and Kinesin motor domain
    9. XM_017025157.1XP_016880646.1  unconventional myosin-XIX isoform X1

      Conserved Domains (1) summary
      cd14880
      Location:49823
      MYSc_Myo19; class XIX myosin, motor domain
    10. XM_024450957.1XP_024306725.1  unconventional myosin-XIX isoform X7

      Conserved Domains (1) summary
      cl22853
      Location:45630
      Motor_domain; Myosin and Kinesin motor domain
    11. XM_024450956.1XP_024306724.1  unconventional myosin-XIX isoform X3

      Conserved Domains (1) summary
      cd14880
      Location:49792
      MYSc_Myo19; class XIX myosin, motor domain
    12. XM_024450954.1XP_024306722.1  unconventional myosin-XIX isoform X1

      Conserved Domains (1) summary
      cd14880
      Location:49823
      MYSc_Myo19; class XIX myosin, motor domain
    13. XM_024450958.1XP_024306726.1  unconventional myosin-XIX isoform X8

      Conserved Domains (1) summary
      cl22853
      Location:33481
      Motor_domain; Myosin and Kinesin motor domain

    RNA

    1. XR_001752651.2 RNA Sequence

    2. XR_001752649.2 RNA Sequence

    3. XR_001752647.2 RNA Sequence

    4. XR_001752648.2 RNA Sequence

    5. XR_001752650.2 RNA Sequence

    6. XR_001752652.2 RNA Sequence

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      730659..770361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033579.1: Suppressed sequence

      Description
      NM_001033579.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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