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    FBXL18 F-box and leucine rich repeat protein 18 [ Homo sapiens (human) ]

    Gene ID: 80028, updated on 10-Dec-2024

    Summary

    Official Symbol
    FBXL18provided by HGNC
    Official Full Name
    F-box and leucine rich repeat protein 18provided by HGNC
    Primary source
    HGNC:HGNC:21874
    See related
    Ensembl:ENSG00000155034 MIM:609084; AllianceGenome:HGNC:21874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fbl18
    Summary
    The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in brain (RPKM 2.3), fat (RPKM 1.2) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FBXL18 in Genome Data Viewer
    Location:
    7p22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (5454425..5513809, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (5571979..5631328, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5494056..5553440, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 29 member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5350589-5351090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5351091-5351590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5362189-5362722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5362723-5363256 Neighboring gene trinucleotide repeat containing 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5387551-5388392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5390077-5390917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5395754-5396256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5421456-5422020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5422021-5422584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5441055-5441556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5443987-5444488 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5447331-5447920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5447921-5448510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5458249-5458998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5467243-5467992 Neighboring gene long intergenic non-protein coding RNA 2983 Neighboring gene long intergenic non-protein coding RNA 3073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5485342-5486174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5491262-5491967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5495336-5495836 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5526631-5527352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5528075-5528796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5549867-5550805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17916 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:5552897-5553483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5553484-5554070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5554071-5554656 Neighboring gene microRNA 589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25586 Neighboring gene uncharacterized LOC221946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25587 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5567118-5567988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5567989-5568858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5568859-5569728 Neighboring gene actin beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10776, FLJ11467, FLJ26934, FLJ38075, FLJ41541

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321213.2NP_001308142.1  F-box/LRR-repeat protein 18 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC006483, AC092171
      UniProtKB/TrEMBL
      A0A994ENR3
      Conserved Domains (3) summary
      sd00034
      Location:345384
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3375
      F-box-like; F-box-like
      pfam13900
      Location:763779
      GVQW; Putative domain of unknown function
    2. NM_001363441.2NP_001350370.1  F-box/LRR-repeat protein 18 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC006483, AC092171
      Related
      ENSP00000415064.1, ENST00000415009.5
      Conserved Domains (2) summary
      sd00034
      Location:345384
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3368
      F-box-like; F-box-like
    3. NM_001363442.2NP_001350371.1  F-box/LRR-repeat protein 18 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC006483, AC092171
      UniProtKB/TrEMBL
      A0A994ENR3
      Conserved Domains (2) summary
      sd00034
      Location:345384
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3368
      F-box-like; F-box-like
    4. NM_001367780.1NP_001354709.1  F-box/LRR-repeat protein 18 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform 5.
      Source sequence(s)
      AC006483, AC092171
      UniProtKB/TrEMBL
      A0A994ENR3
    5. NM_001367781.1NP_001354710.1  F-box/LRR-repeat protein 18 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 5, encodes isoform 5.
      Source sequence(s)
      AC006483, AC092171
      UniProtKB/TrEMBL
      A0A994ENR3
    6. NM_024963.6NP_079239.3  F-box/LRR-repeat protein 18 isoform 2

      See identical proteins and their annotated locations for NP_079239.3

      Status: REVIEWED

      Source sequence(s)
      AA878073, AC006483, AC092171, AK294949, BC013435, DC307306
      Consensus CDS
      CCDS43546.1
      UniProtKB/Swiss-Prot
      A0A024R857, B3KTC9, B4DH63, H0Y6I6, Q96ME1, Q9BR90, Q9BTC7, Q9HAK7
      Related
      ENSP00000371805.3, ENST00000382368.8
      Conserved Domains (2) summary
      sd00034
      Location:345384
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:3375
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      5454425..5513809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      5571979..5631328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)