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    MYO15B myosin XVB [ Homo sapiens (human) ]

    Gene ID: 80022, updated on 17-Jun-2024

    Summary

    Official Symbol
    MYO15Bprovided by HGNC
    Official Full Name
    myosin XVBprovided by HGNC
    Primary source
    HGNC:HGNC:14083
    See related
    Ensembl:ENSG00000266714 AllianceGenome:HGNC:14083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYO15BP
    Summary
    Predicted to enable ATP binding activity; actin binding activity; and cytoskeletal motor activity. Predicted to be located in brush border; cytoplasm; and cytoskeleton. Predicted to be part of myosin complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in duodenum (RPKM 37.9), small intestine (RPKM 33.6) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MYO15B in Genome Data Viewer
    Location:
    17q25.1
    Exon count:
    67
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75587800..75626849)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76480978..76520034)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73583881..73622929)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8971 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73521300-73521484 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene LLGL scribble cell polarity complex component 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73537609-73538426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73540787-73541589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73548510-73549090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73553000-73553936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73553937-73554872 Neighboring gene Sharpr-MPRA regulatory region 3602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12769 Neighboring gene Sharpr-MPRA regulatory region 12965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73583697-73584530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73584531-73585362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73628586-73629266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73629267-73629946 Neighboring gene RecQ like helicase 5 Neighboring gene Sharpr-MPRA regulatory region 461 Neighboring gene HNF1 motif-containing MPRA enhancer 181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12771 Neighboring gene small integral membrane protein 5 Neighboring gene small integral membrane protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21606, FLJ22686, FLJ40577, FLJ44494, KIAA1783

    General protein information

    Preferred Names
    myosin XVB
    Names
    myosin XVB pseudogene
    unconventional myosin XVBP pseudogene

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309242.2NP_001296171.1  myosin XVB isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087749, KF511237
      UniProtKB/Swiss-Prot
      Q96JP2
      UniProtKB/TrEMBL
      Q9H614
      Conserved Domains (10) summary
      cd12068
      Location:24472501
      SH3_MYO15B; Src Homology 3 domain of Myosin XVb
      smart00139
      Location:26052743
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:7171356
      MYSc; Myosin. Large ATPases
      smart00295
      Location:27592955
      B41; Band 4.1 homologues
      cd13201
      Location:29513052
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cl22853
      Location:7341344
      Motor_domain; Myosin and Kinesin motor domain
      pfam00373
      Location:28442955
      FERM_M; FERM central domain
      pfam00784
      Location:15601662
      MyTH4; MyTH4 domain
      cl00936
      Location:165309
      RecX; RecX family
      cl17171
      Location:23492443
      PH-like; Pleckstrin homology-like domain
    2. NM_001395058.1NP_001381987.1  myosin XVB isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087749, KF511237
      Consensus CDS
      CCDS92396.1
      UniProtKB/Swiss-Prot
      A0A0J9YVZ6, A0A2R8YFM0, Q96JP2
      Related
      ENSP00000495242.3, ENST00000645453.3
      Conserved Domains (9) summary
      cd12068
      Location:24852539
      SH3_MYO15B; Src Homology 3 domain of Myosin XVb
      smart00139
      Location:26432781
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:27972993
      B41; Band 4.1 homologues
      PHA03307
      Location:9358
      PHA03307; transcriptional regulator ICP4; Provisional
      PRK12678
      Location:272494
      PRK12678; transcription termination factor Rho; Provisional
      cd13201
      Location:29893090
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14896
      Location:7341382
      MYSc_Myo35; class XXXV myosin, motor domain
      cl02480
      Location:15551700
      MyTH4; MyTH4 domain
      cl17171
      Location:23872481
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      75587800..75626849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025120.3XP_016880609.1  myosin XVB isoform X1

    2. XM_017025123.3XP_016880612.1  myosin XVB isoform X4

    3. XM_017025125.3XP_016880614.1  myosin XVB isoform X6

    4. XM_017025124.3XP_016880613.1  myosin XVB isoform X5

    5. XM_017025122.3XP_016880611.1  myosin XVB isoform X3

    6. XM_017025121.3XP_016880610.1  myosin XVB isoform X2

    7. XM_017025127.3XP_016880616.1  myosin XVB isoform X8

    8. XM_047436788.1XP_047292744.1  myosin XVB isoform X7

    9. XM_047436789.1XP_047292745.1  myosin XVB isoform X10

    10. XM_047436795.1XP_047292751.1  myosin XVB isoform X19

    11. XM_047436796.1XP_047292752.1  myosin XVB isoform X22

    12. XM_047436798.1XP_047292754.1  myosin XVB isoform X26

    13. XM_017025128.3XP_016880617.1  myosin XVB isoform X9

    14. XM_047436792.1XP_047292748.1  myosin XVB isoform X16

    15. XM_017025131.3XP_016880620.1  myosin XVB isoform X13

    16. XM_047436790.1XP_047292746.1  myosin XVB isoform X14

    17. XM_017025129.3XP_016880618.1  myosin XVB isoform X11

    18. XM_047436791.1XP_047292747.1  myosin XVB isoform X15

    19. XM_017025130.3XP_016880619.1  myosin XVB isoform X12

    20. XM_047436793.1XP_047292749.1  myosin XVB isoform X17

    21. XM_047436794.1XP_047292750.1  myosin XVB isoform X18

    22. XM_017025135.3XP_016880624.1  myosin XVB isoform X20

      UniProtKB/TrEMBL
      A0A286YF23
      Related
      ENST00000633867.1
    23. XM_017025136.3XP_016880625.1  myosin XVB isoform X20

      UniProtKB/TrEMBL
      A0A286YF23
    24. XM_017025137.3XP_016880626.1  myosin XVB isoform X21

      UniProtKB/TrEMBL
      A0A286YF23
    25. XM_047436797.1XP_047292753.1  myosin XVB isoform X24

      UniProtKB/TrEMBL
      A0A286YF23
    26. XM_017025138.3XP_016880627.1  myosin XVB isoform X23

      UniProtKB/TrEMBL
      A0A286YF23
    27. XM_017025140.3XP_016880629.1  myosin XVB isoform X25

      UniProtKB/TrEMBL
      A0A286YF23
      Related
      ENSP00000492911.2, ENST00000642007.2
    28. XM_017025143.3XP_016880632.1  myosin XVB isoform X27

      UniProtKB/TrEMBL
      A0A286YF23
    29. XM_024450952.2XP_024306720.1  myosin XVB isoform X28

      UniProtKB/TrEMBL
      A0A286YF23
      Conserved Domains (5) summary
      cd12068
      Location:802856
      SH3_MYO15B; Src Homology 3 domain of Myosin XVb
      smart00139
      Location:9601098
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00295
      Location:11141310
      B41; Band 4.1 homologues
      cd13201
      Location:13061407
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cl17171
      Location:704798
      PH-like; Pleckstrin homology-like domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      76480978..76520034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317332.1XP_054173307.1  myosin XVB isoform X26

    2. XM_054317328.1XP_054173303.1  myosin XVB isoform X22

    3. XM_054317324.1XP_054173299.1  myosin XVB isoform X19

    4. XM_054317314.1XP_054173289.1  myosin XVB isoform X10

    5. XM_054317309.1XP_054173284.1  myosin XVB isoform X7

    6. XM_054317306.1XP_054173281.1  myosin XVB isoform X4

    7. XM_054317303.1XP_054173278.1  myosin XVB isoform X1

    8. XM_054317307.1XP_054173282.1  myosin XVB isoform X5

    9. XM_054317305.1XP_054173280.1  myosin XVB isoform X3

    10. XM_054317304.1XP_054173279.1  myosin XVB isoform X2

    11. XM_054317308.1XP_054173283.1  myosin XVB isoform X6

    12. XM_054317310.1XP_054173285.1  myosin XVB isoform X29

    13. XM_054317311.1XP_054173286.1  myosin XVB isoform X30

    14. XM_054317312.1XP_054173287.1  myosin XVB isoform X8

    15. XM_054317313.1XP_054173288.1  myosin XVB isoform X9

    16. XM_054317320.1XP_054173295.1  myosin XVB isoform X16

    17. XM_054317317.1XP_054173292.1  myosin XVB isoform X13

    18. XM_054317318.1XP_054173293.1  myosin XVB isoform X14

    19. XM_054317315.1XP_054173290.1  myosin XVB isoform X11

    20. XM_054317319.1XP_054173294.1  myosin XVB isoform X15

    21. XM_054317316.1XP_054173291.1  myosin XVB isoform X12

    22. XM_054317321.1XP_054173296.1  myosin XVB isoform X17

    23. XM_054317322.1XP_054173297.1  myosin XVB isoform X18

    24. XM_054317326.1XP_054173301.1  myosin XVB isoform X20

      UniProtKB/TrEMBL
      A0A286YF23
    25. XM_054317323.1XP_054173298.1  myosin XVB isoform X31

    26. XM_054317325.1XP_054173300.1  myosin XVB isoform X20

      UniProtKB/TrEMBL
      A0A286YF23
    27. XM_054317327.1XP_054173302.1  myosin XVB isoform X21

      UniProtKB/TrEMBL
      A0A286YF23
    28. XM_054317330.1XP_054173305.1  myosin XVB isoform X24

      UniProtKB/TrEMBL
      A0A286YF23
    29. XM_054317329.1XP_054173304.1  myosin XVB isoform X23

      UniProtKB/TrEMBL
      A0A286YF23
    30. XM_054317334.1XP_054173309.1  myosin XVB isoform X32

      UniProtKB/TrEMBL
      A0A286YF23
    31. XM_054317333.1XP_054173308.1  myosin XVB isoform X32

      UniProtKB/TrEMBL
      A0A286YF23
    32. XM_054317331.1XP_054173306.1  myosin XVB isoform X25

      UniProtKB/TrEMBL
      A0A286YF23
    33. XM_054317335.1XP_054173310.1  myosin XVB isoform X27

      UniProtKB/TrEMBL
      A0A286YF23
    34. XM_054317336.1XP_054173311.1  myosin XVB isoform X28

      UniProtKB/TrEMBL
      A0A286YF23

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080847.1: Suppressed sequence

      Description
      NM_001080847.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
    2. NR_003587.2: Suppressed sequence

      Description
      NR_003587.2: This RefSeq was removed because it is now thought that this gene does encode a protein.