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    TMEM62 transmembrane protein 62 [ Homo sapiens (human) ]

    Gene ID: 80021, updated on 23-Nov-2021

    Summary

    Official Symbol
    TMEM62provided by HGNC
    Official Full Name
    transmembrane protein 62provided by HGNC
    Primary source
    HGNC:HGNC:26269
    See related
    Ensembl:ENSG00000137842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in colon (RPKM 6.4), duodenum (RPKM 6.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See TMEM62 in Genome Data Viewer
    Location:
    15q15.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43133115..43185147)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43425313..43477342)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RPS3A pseudogene 47 Neighboring gene signal peptidase complex subunit 2 pseudogene 1 Neighboring gene farnesyl diphosphate synthase pseudogene 10 Neighboring gene cyclin D1 binding protein 1 Neighboring gene erythrocyte membrane protein band 4.2 Neighboring gene transglutaminase 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ23375

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347004.1NP_001333933.1  transmembrane protein 62 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 3-5, encodes isoform b.
      Source sequence(s)
      AC068724
    2. NM_001347005.2NP_001333934.1  transmembrane protein 62 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 2, 4, and 5, encodes isoform b.
      Source sequence(s)
      AC068724
    3. NM_001347006.2NP_001333935.1  transmembrane protein 62 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 2, 3, and 5, encodes isoform b.
      Source sequence(s)
      AC068724
    4. NM_001347007.2NP_001333936.1  transmembrane protein 62 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 2-4, encodes isoform b.
      Source sequence(s)
      AC068724
    5. NM_001347008.1NP_001333937.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 7-11, encodes isoform c.
      Source sequence(s)
      AC068724
    6. NM_001347009.1NP_001333938.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 6 and 8-11, encodes isoform c.
      Source sequence(s)
      AC068724
    7. NM_001347010.2NP_001333939.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 6-7 and 9-11, encodes isoform c.
      Source sequence(s)
      AC068724
    8. NM_001347011.2NP_001333940.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 6-8 and 10-11, encodes isoform c.
      Source sequence(s)
      AC068724
    9. NM_001347012.2NP_001333941.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 6-9 and 11, encodes isoform c.
      Source sequence(s)
      AC068724
    10. NM_001347013.2NP_001333942.1  transmembrane protein 62 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 6-10, encodes isoform c.
      Source sequence(s)
      AC068724
    11. NM_001347014.1NP_001333943.1  transmembrane protein 62 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform d.
      Source sequence(s)
      AC068724
    12. NM_001347015.2NP_001333944.1  transmembrane protein 62 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform d.
      Source sequence(s)
      AC068724
    13. NM_001347016.2NP_001333945.1  transmembrane protein 62 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform d.
      Source sequence(s)
      AC068724
    14. NM_001347017.2NP_001333946.1  transmembrane protein 62 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform e.
      Source sequence(s)
      AC068724
    15. NM_001347018.2NP_001333947.1  transmembrane protein 62 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform e.
      Source sequence(s)
      AC068724
    16. NM_001347019.1NP_001333948.1  transmembrane protein 62 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variants 18-20, encodes isoform f.
      Source sequence(s)
      AC068724
    17. NM_001347020.2NP_001333949.1  transmembrane protein 62 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variants 17 and 19-20, encodes isoform f.
      Source sequence(s)
      AC068724
    18. NM_001347021.2NP_001333950.1  transmembrane protein 62 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variants 17-18 and 20, encodes isoform f.
      Source sequence(s)
      AC068724
    19. NM_001347023.2NP_001333952.1  transmembrane protein 62 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variants 17-19, encodes isoform f.
      Source sequence(s)
      AC068724
    20. NM_001347024.1NP_001333953.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21), as well as variants 22-26, encodes isoform g.
      Source sequence(s)
      AC068724
    21. NM_001347025.1NP_001333954.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22), as well as variants 21 and 23-26, encodes isoform g.
      Source sequence(s)
      AC068724
    22. NM_001347026.2NP_001333955.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23), as well as variants 21-22 and 24-26, encodes isoform g.
      Source sequence(s)
      AC068724
    23. NM_001347027.2NP_001333956.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24), as well as variants 21-23 and 25-26, encodes isoform g.
      Source sequence(s)
      AC068724
    24. NM_001347028.2NP_001333957.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25), as well as variants 21-24 and 26, encodes isoform g.
      Source sequence(s)
      AC068724
    25. NM_001347029.2NP_001333958.1  transmembrane protein 62 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26), as well as variants 21-25, encodes isoform g.
      Source sequence(s)
      AC068724
    26. NM_001347030.1NP_001333959.1  transmembrane protein 62 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC068724
    27. NM_001347031.2NP_001333960.1  transmembrane protein 62 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC068724
    28. NM_001347032.2NP_001333961.1  transmembrane protein 62 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC068724
      Related
      ENSP00000458098.1, ENST00000564494.1
    29. NM_001347033.2NP_001333962.1  transmembrane protein 62 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC068724
    30. NM_001347034.2NP_001333963.1  transmembrane protein 62 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC068724
    31. NM_024956.4NP_079232.3  transmembrane protein 62 isoform a

      See identical proteins and their annotated locations for NP_079232.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC009981
      Consensus CDS
      CCDS32210.1
      UniProtKB/Swiss-Prot
      Q0P6H9
      Related
      ENSP00000260403.2, ENST00000260403.7
      Conserved Domains (3) summary
      cd07401
      Location:57345
      MPP_TMEM62_N; Homo sapiens TMEM62, N-terminal metallophosphatase domain
      pfam00149
      Location:59259
      Metallophos; Calcineurin-like phosphoesterase
      pfam13754
      Location:351409
      Big_3_4; Bacterial Ig-like domain (group 3)

    RNA

    1. NR_144541.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068724
    2. NR_144542.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068724
    3. NR_144543.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068724
    4. NR_144544.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068724

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      43133115..43185147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522071.1XP_011520373.1  transmembrane protein 62 isoform X1

      See identical proteins and their annotated locations for XP_011520373.1

      Conserved Domains (2) summary
      pfam13754
      Location:221279
      Big_3_4; Bacterial Ig-like domain (group 3)
      cl13995
      Location:1215
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    2. XM_024450072.1XP_024305840.1  transmembrane protein 62 isoform X5

      Conserved Domains (1) summary
      cd07401
      Location:57341
      MPP_TMEM62_N; Homo sapiens TMEM62, N-terminal metallophosphatase domain
    3. XM_011522074.2XP_011520376.1  transmembrane protein 62 isoform X3

      Conserved Domains (2) summary
      pfam13754
      Location:135193
      Big_3_4; Bacterial Ig-like domain (group 3)
      cl13995
      Location:95129
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    4. XM_024450071.1XP_024305839.1  transmembrane protein 62 isoform X4

      Conserved Domains (1) summary
      cl13995
      Location:92126
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    5. XM_011522073.1XP_011520375.1  transmembrane protein 62 isoform X2

      See identical proteins and their annotated locations for XP_011520375.1

      UniProtKB/Swiss-Prot
      Q0P6H9
      Conserved Domains (1) summary
      cl13995
      Location:1137
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
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