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    DOCK5 dedicator of cytokinesis 5 [ Homo sapiens (human) ]

    Gene ID: 80005, updated on 17-Jun-2019

    Summary

    Official Symbol
    DOCK5provided by HGNC
    Official Full Name
    dedicator of cytokinesis 5provided by HGNC
    Primary source
    HGNC:HGNC:23476
    See related
    Ensembl:ENSG00000147459 MIM:616904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
    Expression
    Ubiquitous expression in spleen (RPKM 6.2), small intestine (RPKM 5.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See DOCK5 in Genome Data Viewer
    Location:
    8p21.2
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (25184689..25415711)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (25042287..25273227)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379330 Neighboring gene ependymin related 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 10341 Neighboring gene uncharacterized LOC105379331 Neighboring gene microRNA 6876 Neighboring gene Sharpr-MPRA regulatory region 10380 Neighboring gene gonadotropin releasing hormone 1 Neighboring gene potassium channel tetramerization domain containing 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp451J181, DKFZp779M164, DKFZp781J211

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dedicator of cytokinesis protein 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051765.1 RefSeqGene

      Range
      4952..235945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001322810.2NP_001309739.1  dedicator of cytokinesis protein 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC041005, AC091185, BC015352
      Consensus CDS
      CCDS83265.1
      UniProtKB/TrEMBL
      B9A015
      Related
      ENSP00000387036.1, ENST00000410074.5
    2. NM_024940.8NP_079216.4  dedicator of cytokinesis protein 5 isoform 1

      See identical proteins and their annotated locations for NP_079216.4

      Status: REVIEWED

      Source sequence(s)
      AC041005, AC091185, AK024687, AK026663, AK126249, BC011877, BC015352, BC041761, BE549612, BF195734, BF884637, BX648352, CR627414, CR749353
      Consensus CDS
      CCDS6047.1
      UniProtKB/Swiss-Prot
      Q9H7D0
      UniProtKB/TrEMBL
      Q68DL4
      Related
      ENSP00000276440.7, ENST00000276440.12
      Conserved Domains (4) summary
      cd11708
      Location:12381637
      DHR2_DOCK5; Dock Homology Region 2, a GEF domain, of Class A Dedicator of Cytokinesis 5
      cd12051
      Location:1267
      SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5
      pfam16172
      Location:75434
      DOCK_N; DOCK N-terminus
      cl14603
      Location:442637
      C2; C2 domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      25184689..25415711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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