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    GREB1L GREB1 like retinoic acid receptor coactivator [ Homo sapiens (human) ]

    Gene ID: 80000, updated on 17-Jun-2019

    Summary

    Official Symbol
    GREB1Lprovided by HGNC
    Official Full Name
    GREB1 like retinoic acid receptor coactivatorprovided by HGNC
    Primary source
    HGNC:HGNC:31042
    See related
    Ensembl:ENSG00000141449 MIM:617782
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RHDA3; C18orf6; KIAA1772
    Expression
    Biased expression in testis (RPKM 2.5), thyroid (RPKM 1.4) and 11 other tissues See more
    Orthologs

    Genomic context

    See GREB1L in Genome Data Viewer
    Location:
    18q11.1-q11.2
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (21242225..21528503)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (18822203..19105384)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene EXOG pseudogene 1 Neighboring gene uncharacterized LOC101927496 Neighboring gene uncharacterized LOC101927521 Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 1 Neighboring gene small nuclear ribonucleoprotein D1 polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1772

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac ventricle development IEA
    Inferred from Electronic Annotation
    more info
     
    kidney development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male genitalia development IEA
    Inferred from Electronic Annotation
    more info
     
    mesonephric duct development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephros development IEA
    Inferred from Electronic Annotation
    more info
     
    paramesonephric duct development IEA
    Inferred from Electronic Annotation
    more info
     
    uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    GREB1-like protein
    Names
    growth regulation by estrogen in breast cancer 1 like
    growth regulation by estrogen in breast cancer 1-like protein
    growth regulation by estrogen in breast cancer-like

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142966.2NP_001136438.1  GREB1-like protein

      See identical proteins and their annotated locations for NP_001136438.1

      Status: VALIDATED

      Source sequence(s)
      AC011774, AC015878, AC022809
      Consensus CDS
      CCDS45836.1
      UniProtKB/Swiss-Prot
      Q9C091
      Related
      ENSP00000412060.1, ENST00000424526.5
      Conserved Domains (1) summary
      pfam15782
      Location:11923
      GREB1; Gene regulated by oestrogen in breast cancer

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

      Range
      21242225..21528503
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025989.1XP_016881478.1  GREB1-like protein isoform X1

    2. XM_017025993.1XP_016881482.1  GREB1-like protein isoform X5

    3. XM_006722547.3XP_006722610.1  GREB1-like protein isoform X4

      See identical proteins and their annotated locations for XP_006722610.1

      Conserved Domains (1) summary
      pfam15782
      Location:11967
      GREB1; Gene regulated by oestrogen in breast cancer
    4. XM_011526179.3XP_011524481.1  GREB1-like protein isoform X6

      Conserved Domains (1) summary
      pfam15782
      Location:11900
      GREB1; Gene regulated by oestrogen in breast cancer
    5. XM_017025988.1XP_016881477.1  GREB1-like protein isoform X1

    6. XM_017025990.1XP_016881479.1  GREB1-like protein isoform X2

    7. XM_017025991.1XP_016881480.1  GREB1-like protein isoform X3

    8. XM_017025994.1XP_016881483.1  GREB1-like protein isoform X7

    9. XM_017025995.1XP_016881484.1  GREB1-like protein isoform X8

    10. XM_017025992.1XP_016881481.1  GREB1-like protein isoform X5

    11. XM_017025996.1XP_016881485.1  GREB1-like protein isoform X9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024935.2: Suppressed sequence

      Description
      NM_024935.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and currently there is insufficient support for the transcript.
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