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    CEP76 centrosomal protein 76 [ Homo sapiens (human) ]

    Gene ID: 79959, updated on 5-Aug-2022

    Summary

    Official Symbol
    CEP76provided by HGNC
    Official Full Name
    centrosomal protein 76provided by HGNC
    Primary source
    HGNC:HGNC:25727
    See related
    Ensembl:ENSG00000101624 AllianceGenome:HGNC:25727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C18orf9; HsT1705
    Summary
    This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
    Expression
    Broad expression in testis (RPKM 7.3), esophagus (RPKM 1.7) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CEP76 in Genome Data Viewer
    Location:
    18p11.21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (12661956..12702777, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (12824941..12865780, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12661955..12702776, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene high mobility group box 3 pseudogene 28 Neighboring gene spire type actin nucleation factor 1 Neighboring gene small nucleolar RNA U13 Neighboring gene proteasome assembly chaperone 2 Neighboring gene long intergenic non-protein coding RNA 1882 Neighboring gene protein tyrosine phosphatase non-receptor type 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12542

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    centrosomal protein of 76 kDa
    Names
    centrosomal protein 76kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271989.2NP_001258918.1  centrosomal protein of 76 kDa isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform (b) which is shorter than isoform a.
      Source sequence(s)
      AK298223, AK303117, AP005482, BC026307, DA476378
      Consensus CDS
      CCDS62390.1
      UniProtKB/Swiss-Prot
      Q8TAP6
      UniProtKB/TrEMBL
      B4DP81
      Related
      ENSP00000403074.1, ENST00000423709.6
      Conserved Domains (2) summary
      pfam01841
      Location:290336
      Transglut_core; Transglutaminase-like superfamily
      pfam15627
      Location:96183
      CEP76-C2; CEP76 C2 domain
    2. NM_024899.4NP_079175.2  centrosomal protein of 76 kDa isoform a

      See identical proteins and their annotated locations for NP_079175.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK298223, AP005482, BC026307, DA476378
      Consensus CDS
      CCDS11861.1
      UniProtKB/Swiss-Prot
      Q8TAP6, Q9H9U7
      UniProtKB/TrEMBL
      B4DP81
      Related
      ENSP00000262127.2, ENST00000262127.7
      Conserved Domains (1) summary
      pfam15627
      Location:101258
      CEP76-C2; CEP76 C2 domain

    RNA

    1. NR_073537.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites in internal exons and has an alternate 3' exon. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK298223, AK301964, BC026307, BC033026, BX505397
      Related
      ENST00000590143.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      12661956..12702777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437808.1XP_047293764.1  centrosomal protein of 76 kDa isoform X5

    2. XM_005258149.6XP_005258206.1  centrosomal protein of 76 kDa isoform X2

      Conserved Domains (2) summary
      pfam01841
      Location:365411
      Transglut_core; Transglutaminase-like superfamily
      pfam15627
      Location:101258
      CEP76-C2; CEP76 C2 domain
    3. XM_017025981.2XP_016881470.1  centrosomal protein of 76 kDa isoform X1

    4. XM_017025983.3XP_016881472.1  centrosomal protein of 76 kDa isoform X4

    5. XM_017025982.2XP_016881471.1  centrosomal protein of 76 kDa isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      12824941..12865780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)