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    ZC3H14 zinc finger CCCH-type containing 14 [ Homo sapiens (human) ]

    Gene ID: 79882, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZC3H14provided by HGNC
    Official Full Name
    zinc finger CCCH-type containing 14provided by HGNC
    Primary source
    HGNC:HGNC:20509
    See related
    Ensembl:ENSG00000100722 MIM:613279; AllianceGenome:HGNC:20509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SUT2; MRT56; UKp68; MSUT-2; NY-REN-37
    Summary
    The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. [provided by RefSeq, May 2016]
    Expression
    Broad expression in testis (RPKM 19.6), thyroid (RPKM 8.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZC3H14 in Genome Data Viewer
    Location:
    14q31.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (88563037..88627596)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (82783861..82848491)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (89029381..89093940)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370614 Neighboring gene protein tyrosine phosphatase non-receptor type 21 Neighboring gene RNA, U4 small nuclear 22, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89015655-89016472 Neighboring gene proline-rich protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5992 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:89084698-89085319 Neighboring gene EMAP like 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8843 Neighboring gene MPRA-validated peak2226 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8844 Neighboring gene RNA, U4 small nuclear 92, pseudogene Neighboring gene tetratricopeptide repeat domain 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11806, MGC26892

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in axon cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger CCCH domain-containing protein 14
    Names
    mammalian suppressor of tau pathology-2
    nuclear protein UKp68
    renal carcinoma antigen NY-REN-37

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050601.2 RefSeqGene

      Range
      5002..69561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001160103.2NP_001153575.1  zinc finger CCCH domain-containing protein 14 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (5) lacks one-aa near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AL162171, AL359625, BC011793, BC023641, BC034274, BX248769, DB452844
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:621639
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    2. NM_001160104.2NP_001153576.1  zinc finger CCCH domain-containing protein 14 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. The resulting isoform (6) lacks a five-aa and a one-aa segment, compared to isoform 1.
      Source sequence(s)
      AK304275, AL162171, AL359625, BC011793, BC034274, BX248769, DB452844
      Consensus CDS
      CCDS55938.1
      UniProtKB/TrEMBL
      H0YJA2
      Related
      ENSP00000452475.1, ENST00000555755.5
      Conserved Domains (1) summary
      pfam14608
      Location:616634
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    3. NM_001326295.2NP_001313224.1  zinc finger CCCH domain-containing protein 14 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Consensus CDS
      CCDS86417.1
      UniProtKB/TrEMBL
      G3V256
      Related
      ENSP00000450474.1, ENST00000556945.5
      Conserved Domains (1) summary
      pfam14608
      Location:551567
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    4. NM_001326296.2NP_001313225.1  zinc finger CCCH domain-containing protein 14 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
    5. NM_001326297.2NP_001313226.1  zinc finger CCCH domain-containing protein 14 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:587605
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    6. NM_001326298.2NP_001313227.1  zinc finger CCCH domain-containing protein 14 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Conserved Domains (1) summary
      pfam14608
      Location:526542
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    7. NM_001326299.2NP_001313228.1  zinc finger CCCH domain-containing protein 14 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
    8. NM_001326300.2NP_001313229.1  zinc finger CCCH domain-containing protein 14 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:527543
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    9. NM_001326301.2NP_001313230.1  zinc finger CCCH domain-containing protein 14 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
    10. NM_001326302.2NP_001313231.1  zinc finger CCCH domain-containing protein 14 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Related
      ENSP00000451054.1, ENST00000556000.5
      Conserved Domains (1) summary
      pfam14608
      Location:526542
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    11. NM_001326303.2NP_001313232.1  zinc finger CCCH domain-containing protein 14 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Conserved Domains (1) summary
      pfam14608
      Location:491507
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    12. NM_001326304.2NP_001313233.1  zinc finger CCCH domain-containing protein 14 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      G3V5I6
    13. NM_001326305.2NP_001313234.1  zinc finger CCCH domain-containing protein 14 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:502518
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    14. NM_001326306.2NP_001313235.1  zinc finger CCCH domain-containing protein 14 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Conserved Domains (1) summary
      pfam14608
      Location:473489
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    15. NM_001326307.2NP_001313236.1  zinc finger CCCH domain-containing protein 14 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Consensus CDS
      CCDS86418.1
      UniProtKB/TrEMBL
      H0YJA2
      Related
      ENSP00000377150.5, ENST00000393514.9
      Conserved Domains (1) summary
      pfam14608
      Location:596614
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    16. NM_001326308.2NP_001313237.1  zinc finger CCCH domain-containing protein 14 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      G3V5I6
    17. NM_001326309.2NP_001313238.1  zinc finger CCCH domain-containing protein 14 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      G3V5I6
    18. NM_001326310.2NP_001313239.1  zinc finger CCCH domain-containing protein 14 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:616634
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    19. NM_001326311.2NP_001313240.1  zinc finger CCCH domain-containing protein 14 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      G3V5I6
      Related
      ENSP00000452370.1, ENST00000557607.5
    20. NM_001326312.2NP_001313241.1  zinc finger CCCH domain-containing protein 14 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
    21. NM_001326313.2NP_001313242.1  zinc finger CCCH domain-containing protein 14 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AL162171
      Conserved Domains (1) summary
      pfam14608
      Location:474490
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    22. NM_001326314.2NP_001313243.1  zinc finger CCCH domain-containing protein 14 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
      Conserved Domains (1) summary
      pfam14608
      Location:501517
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    23. NM_001326315.2NP_001313244.1  zinc finger CCCH domain-containing protein 14 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27) and variant 28 both encode the same isoform (27).
      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
    24. NM_001326316.2NP_001313245.1  zinc finger CCCH domain-containing protein 14 isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28) and variant 27 both encode the same isoform (27).
      Source sequence(s)
      AL162171
      UniProtKB/TrEMBL
      H0YJA2
    25. NM_024824.5NP_079100.2  zinc finger CCCH domain-containing protein 14 isoform 1

      See identical proteins and their annotated locations for NP_079100.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL162171, AL359625, BC011793, BC034274, BX248769, DB452844
      Consensus CDS
      CCDS32133.1
      UniProtKB/Swiss-Prot
      A8MY46, B4DXU8, B4DZW7, B4E2H4, G3V5R4, Q6MZU4, Q6PJ32, Q6PJT7, Q6PUI6, Q6PUI8, Q86TQ5, Q86TW0, Q86TW1, Q8NCT6, Q8NCZ3, Q8TDE2, Q9HAC9, Q9Y5A0
      UniProtKB/TrEMBL
      H0YJA2
      Related
      ENSP00000251038.5, ENST00000251038.10
      Conserved Domains (1) summary
      pfam14608
      Location:621639
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    26. NM_207660.4NP_997543.1  zinc finger CCCH domain-containing protein 14 isoform 2

      See identical proteins and their annotated locations for NP_997543.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks three alternate exons in the central coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment and one-aa near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AL162171, AL359625, AY578061, BC034274, BX248769
      Consensus CDS
      CCDS32134.1
      UniProtKB/Swiss-Prot
      Q6PJT7
      Related
      ENSP00000307025.8, ENST00000302216.12
    27. NM_207661.3NP_997544.1  zinc finger CCCH domain-containing protein 14 isoform 3

      See identical proteins and their annotated locations for NP_997544.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter, uses a downstream start codon, and lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AF474376, AL162171, AY578062, BC034274, BX248769
      Consensus CDS
      CCDS32135.1
      UniProtKB/Swiss-Prot
      Q6PJT7
      Related
      ENSP00000338002.4, ENST00000336693.8
      Conserved Domains (1) summary
      pfam14608
      Location:517533
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger
    28. NM_207662.4NP_997545.2  zinc finger CCCH domain-containing protein 14 isoform 4

      See identical proteins and their annotated locations for NP_997545.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate promoter, lacks two alternate exons in the central coding region, and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, and lacks an internal segment and one-aa near the C-terminus, compared to isoform 1.
      Source sequence(s)
      AL162171, AL359625, BC027607, BC034274, BX248769, DB050247
      Consensus CDS
      CCDS32136.1
      UniProtKB/Swiss-Prot
      Q6PJT7
      Related
      ENSP00000327176.6, ENST00000318308.10
      Conserved Domains (1) summary
      pfam14608
      Location:252268
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    RNA

    1. NR_136936.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL162171

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      88563037..88627596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537162.4XP_011535464.1  zinc finger CCCH domain-containing protein 14 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      82783861..82848491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376723.1XP_054232698.1  zinc finger CCCH domain-containing protein 14 isoform X1