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    DCAKD dephospho-CoA kinase domain containing [ Homo sapiens (human) ]

    Gene ID: 79877, updated on 17-Jun-2019

    Summary

    Official Symbol
    DCAKDprovided by HGNC
    Official Full Name
    dephospho-CoA kinase domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:26238
    See related
    Ensembl:ENSG00000172992
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in brain (RPKM 10.9), thyroid (RPKM 9.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See DCAKD in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (45023338..45061131, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43100706..43138473, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene basic proline-rich protein-like Neighboring gene uncharacterized LOC107987243 Neighboring gene N-myristoyltransferase 1 Neighboring gene phospholipase C delta 3 Neighboring gene microRNA 6784

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22955

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    dephospho-CoA kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    membrane HDA PubMed 

    General protein information

    Preferred Names
    dephospho-CoA kinase domain-containing protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128631.3NP_001122103.1  dephospho-CoA kinase domain-containing protein

      See identical proteins and their annotated locations for NP_001122103.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC015936, AC116493
      Consensus CDS
      CCDS11493.1
      UniProtKB/Swiss-Prot
      Q8WVC6
      Related
      ENSP00000467913.1, ENST00000588499.5
      Conserved Domains (1) summary
      PRK00081
      Location:1196
      coaE; dephospho-CoA kinase; Reviewed
    2. NM_001288654.2NP_001275583.1  dephospho-CoA kinase domain-containing protein

      See identical proteins and their annotated locations for NP_001275583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC015936, AI497945, BC018132, BF115235, BX487139, HY061203
      Consensus CDS
      CCDS11493.1
      UniProtKB/Swiss-Prot
      Q8WVC6
      Related
      ENSP00000308515.5, ENST00000310604.8
      Conserved Domains (1) summary
      PRK00081
      Location:1196
      coaE; dephospho-CoA kinase; Reviewed
    3. NM_001288655.2NP_001275584.1  dephospho-CoA kinase domain-containing protein

      See identical proteins and their annotated locations for NP_001275584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC015936, AC116493
      Consensus CDS
      CCDS11493.1
      UniProtKB/Swiss-Prot
      Q8WVC6
      Related
      ENSP00000478909.1, ENST00000614054.4
      Conserved Domains (1) summary
      PRK00081
      Location:1196
      coaE; dephospho-CoA kinase; Reviewed
    4. NM_001321326.2NP_001308255.1  dephospho-CoA kinase domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      AC015936, AC116493
      Consensus CDS
      CCDS11493.1
      UniProtKB/Swiss-Prot
      Q8WVC6
      Related
      ENSP00000413483.1, ENST00000452796.6
      Conserved Domains (1) summary
      PRK00081
      Location:1196
      coaE; dephospho-CoA kinase; Reviewed
    5. NM_024819.7NP_079095.3  dephospho-CoA kinase domain-containing protein

      See identical proteins and their annotated locations for NP_079095.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-5 encode the same protein.
      Source sequence(s)
      AC015936, AC116493
      Consensus CDS
      CCDS11493.1
      UniProtKB/Swiss-Prot
      Q8WVC6
      Related
      ENSP00000341504.4, ENST00000342350.9
      Conserved Domains (1) summary
      PRK00081
      Location:1196
      coaE; dephospho-CoA kinase; Reviewed

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      45023338..45061131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017025105.1XP_016880594.1  dephospho-CoA kinase domain-containing protein isoform X3

    2. XM_011525262.2XP_011523564.1  dephospho-CoA kinase domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_011523564.1

      UniProtKB/Swiss-Prot
      Q8WVC6
      Conserved Domains (1) summary
      PRK00081
      Location:1196
      coaE; dephospho-CoA kinase; Reviewed
    3. XM_017025104.1XP_016880593.1  dephospho-CoA kinase domain-containing protein isoform X2

      UniProtKB/Swiss-Prot
      Q8WVC6
      Conserved Domains (2) summary
      COG0237
      Location:1107
      CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
      cl17190
      Location:198
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    4. XM_017025103.1XP_016880592.1  dephospho-CoA kinase domain-containing protein isoform X2

      UniProtKB/Swiss-Prot
      Q8WVC6
      Conserved Domains (2) summary
      COG0237
      Location:1107
      CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
      cl17190
      Location:198
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    5. XM_005257688.2XP_005257745.1  dephospho-CoA kinase domain-containing protein isoform X2

      See identical proteins and their annotated locations for XP_005257745.1

      UniProtKB/Swiss-Prot
      Q8WVC6
      Conserved Domains (2) summary
      COG0237
      Location:1107
      CoaE; Dephospho-CoA kinase [Coenzyme transport and metabolism]
      cl17190
      Location:198
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RNA

    1. XR_002958070.1 RNA Sequence

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