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    NUDT18 nudix hydrolase 18 [ Homo sapiens (human) ]

    Gene ID: 79873, updated on 17-Jun-2019

    Summary

    Official Symbol
    NUDT18provided by HGNC
    Official Full Name
    nudix hydrolase 18provided by HGNC
    Primary source
    HGNC:HGNC:26194
    See related
    Ensembl:ENSG00000275074 MIM:615791
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MTH3
    Summary
    The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]
    Expression
    Ubiquitous expression in spleen (RPKM 3.1), lymph node (RPKM 2.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See NUDT18 in Genome Data Viewer
    Location:
    8p21.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (22106872..22110355, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (21964383..21966932, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs781 Neighboring gene dematin actin binding protein Neighboring gene family with sequence similarity 160 member B2 Neighboring gene HR lysine demethylase and nuclear receptor corepressor Neighboring gene receptor accessory protein 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of nucleotides, organism-specific biosystem (from REACTOME)
      Metabolism of nucleotides, organism-specific biosystemNucleotides and their derivatives are used for short-term energy storage (ATP, GTP), for intra- and extra-cellular signaling (cAMP; adenosine), as enzyme cofactors (NAD, FAD), and for the synthesis o...
    • Phosphate bond hydrolysis by NUDT proteins, organism-specific biosystem (from REACTOME)
      Phosphate bond hydrolysis by NUDT proteins, organism-specific biosystemEnzymes that belong to the NUDT (Nudix) superfamily catalyze the hydrolysis of phosphodiester bonds in molecules including nucleoside triphosphates and diphosphates and nucleotide sugars. Family memb...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22494

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    8-hydroxy-dADP phosphatase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    8-hydroxy-dADP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    8-oxo-GDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    8-oxo-dGDP phosphatase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    8-oxo-dGDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    GDP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dADP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dGDP catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleobase-containing small molecule catabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    8-oxo-dGDP phosphatase NUDT18
    Names
    2-hydroxy-dADP phosphatase
    7,8-dihydro-8-oxoguanine phosphatase
    mutT homolog 3
    mutT human homolog 3
    nucleoside diphosphate-linked moiety X motif 18
    nudix (nucleoside diphosphate linked moiety X)-type motif 18
    nudix motif 18
    NP_079091.3
    XP_011542952.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032941.1 RefSeqGene

      Range
      5001..7548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_024815.4NP_079091.3  8-oxo-dGDP phosphatase NUDT18

      See identical proteins and their annotated locations for NP_079091.3

      Status: REVIEWED

      Source sequence(s)
      AC091171, BC016902, DA015404
      Consensus CDS
      CCDS75706.1
      UniProtKB/Swiss-Prot
      Q6ZVK8
      Related
      ENSP00000480722.1, ENST00000611621.2
      Conserved Domains (1) summary
      cd04671
      Location:44166
      Nudix_Hydrolase_13; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      22106872..22110355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544650.1XP_011542952.1  8-oxo-dGDP phosphatase NUDT18 isoform X1

      Conserved Domains (1) summary
      cd04671
      Location:260382
      Nudix_Hydrolase_13; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
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