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    TXNDC15 thioredoxin domain containing 15 [ Homo sapiens (human) ]

    Gene ID: 79770, updated on 13-Feb-2019

    Summary

    Official Symbol
    TXNDC15provided by HGNC
    Official Full Name
    thioredoxin domain containing 15provided by HGNC
    Primary source
    HGNC:HGNC:20652
    See related
    Ensembl:ENSG00000113621 MIM:617778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BUG; UNQ335; C5orf14
    Summary
    This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. [provided by RefSeq, Apr 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 14.9), endometrium (RPKM 10.8) and 25 other tissues See more
    Orthologs

    Genomic context

    See TXNDC15 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (134873770..134901633)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134209427..134237323)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 46 Neighboring gene ribosomal protein L34 pseudogene 13 Neighboring gene chromosome 5 open reading frame 24 Neighboring gene pterin-4 alpha-carbinolamine dehydratase 2 Neighboring gene MT-CYB pseudogene 18 Neighboring gene MT-ND6 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ22625

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    thioredoxin domain-containing protein 15
    Names
    2310047H23Rik
    disulfide isomerase

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053174.1 RefSeqGene

      Range
      5001..32864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350735.1NP_001337664.1  thioredoxin domain-containing protein 15 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC006077
      Related
      ENSP00000423513.1, ENST00000508779.1
      Conserved Domains (1) summary
      cd02999
      Location:120223
      PDI_a_ERp44_like; PDIa family, endoplasmic reticulum protein 44 (ERp44)-like subfamily; composed of uncharacterized PDI-like eukaryotic proteins containing only one redox active TRX (a) domain with a CXXS motif, similar to ERp44. CXXS is still a redox active motif; ...
    2. NM_024715.3NP_078991.3  thioredoxin domain-containing protein 15 isoform 1 precursor

      See identical proteins and their annotated locations for NP_078991.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC006077, BC032568, BX538131
      Consensus CDS
      CCDS4180.1
      UniProtKB/Swiss-Prot
      Q96J42
      UniProtKB/TrEMBL
      Q7Z345
      Related
      ENSP00000351157.4, ENST00000358387.8
      Conserved Domains (1) summary
      cd02999
      Location:188291
      PDI_a_ERp44_like; PDIa family, endoplasmic reticulum protein 44 (ERp44)-like subfamily; composed of uncharacterized PDI-like eukaryotic proteins containing only one redox active TRX (a) domain with a CXXS motif, similar to ERp44. CXXS is still a redox active motif; ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

      Range
      134873770..134901633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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