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    TNFAIP8L2 TNF alpha induced protein 8 like 2 [ Homo sapiens (human) ]

    Gene ID: 79626, updated on 18-Jun-2019


    Official Symbol
    TNFAIP8L2provided by HGNC
    Official Full Name
    TNF alpha induced protein 8 like 2provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000163154 MIM:612112
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Broad expression in spleen (RPKM 30.0), lymph node (RPKM 26.2) and 14 other tissues See more

    Genomic context

    See TNFAIP8L2 in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151156649..151159749)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151129095..151132731)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GA binding protein transcription factor subunit beta 2 Neighboring gene ribosomal protein S29 pseudogene 29 Neighboring gene semaphorin 6C Neighboring gene TNFAIP8L2-SCNM1 readthrough Neighboring gene LysM domain containing 1 Neighboring gene sodium channel modifier 1 Neighboring gene tropomodulin 4 Neighboring gene vacuolar protein sorting 72 homolog

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018


    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • PI Metabolism, organism-specific biosystem (from REACTOME)
      PI Metabolism, organism-specific biosystemPhosphatidylinositol (PI), a membrane phospholipid, can be reversibly phosphorylated at the 3, 4, and 5 positions of the inositol ring to generate seven phosphoinositides: phosphatidylinositol 3-phos...
    • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
      Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Readthrough TNFAIP8L2-SCNM1

    Readthrough gene: TNFAIP8L2-SCNM1, Included gene: SCNM1


    Clone Names

    • FLJ23467

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    Process Evidence Code Pubs
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
    negative regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info

    General protein information

    Preferred Names
    tumor necrosis factor alpha-induced protein 8-like protein 2
    TNF alpha-induced protein 8-like protein 2
    TNFAIP8-like protein 2
    inflammation factor 20
    inflammation factor protein 20
    tumor necrosis factor, alpha induced protein 8 like 2
    tumor necrosis factor, alpha-induced protein 8-like protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024575.5NP_078851.2  tumor necrosis factor alpha-induced protein 8-like protein 2

      See identical proteins and their annotated locations for NP_078851.2

      Status: VALIDATED

      Source sequence(s)
      BC063014, BI833715
      Consensus CDS
      ENSP00000357906.3, ENST00000368910.4
      Conserved Domains (1) summary
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly


    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)
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