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    Fabp4 fatty acid binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79451, updated on 2-Nov-2024

    Summary

    Official Symbol
    Fabp4provided by RGD
    Official Full Name
    fatty acid binding protein 4provided by RGD
    Primary source
    RGD:69309
    See related
    EnsemblRapid:ENSRNOG00000010805 AllianceGenome:RGD:69309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    aP2; Albp
    Summary
    Predicted to enable hormone receptor binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including fatty acid metabolic process; response to glucocorticoid; and response to gravity. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Biomarker of impotence and muscular atrophy. Orthologous to human FABP4 (fatty acid binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 8769.0), Adrenal (RPKM 8627.2) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Fabp4 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (93488251..93492961)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (91580879..91585567)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (93792666..93797267)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093158 Neighboring gene fatty acid binding protein 12 Neighboring gene fatty acid binding protein 9 Neighboring gene RNA, U6 small nuclear 999

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty acid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables long-chain fatty acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to lithium ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-chain fatty acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of fat cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to gravity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within white fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lipid droplet TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    fatty acid-binding protein, adipocyte
    Names
    A-FABP
    AFABP
    adipocyte lipid-binding protein
    adipocyte-type fatty acid-binding protein
    fatty acid binding protein 4, adipocyte

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053365.3NP_445817.2  fatty acid-binding protein, adipocyte

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P70623
      UniProtKB/TrEMBL
      F7FMV4, Q5XFV4
      Related
      ENSRNOP00000014701.5, ENSRNOT00000014701.9
      Conserved Domains (1) summary
      cl10502
      Location:2131
      lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      93488251..93492961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282611.1XP_063138681.1  fatty acid-binding protein, adipocyte isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7N0
      Related
      ENSRNOP00000077522.1, ENSRNOT00000102431.2