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    LRFN3 leucine rich repeat and fibronectin type III domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 79414, updated on 17-Jun-2019

    Summary

    Official Symbol
    LRFN3provided by HGNC
    Official Full Name
    leucine rich repeat and fibronectin type III domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:28370
    See related
    Ensembl:ENSG00000126243 MIM:612809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SALM4; FIGLER1
    Expression
    Ubiquitous expression in brain (RPKM 3.2), fat (RPKM 3.1) and 24 other tissues See more
    Orthologs

    Genomic context

    See LRFN3 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35937120..35945195)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36428022..36436097)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene TYRO protein tyrosine kinase binding protein Neighboring gene hematopoietic cell signal transducer Neighboring gene uncharacterized LOC105372383 Neighboring gene Sharpr-MPRA regulatory region 1826 Neighboring gene succinate dehydrogenase complex assembly factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
      Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...
    • SALM protein interactions at the synapses, organism-specific biosystem (from REACTOME)
      SALM protein interactions at the synapses, organism-specific biosystemRecruitment of receptors and ion channels to the postsynaptic membrane is the last step in synapse formation. Many of these proteins interact directly or indirectly with postsynaptic density-95 (PSD9...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC2656

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    regulation of presynapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat and fibronectin type-III domain-containing protein 3
    Names
    fibronectin type III, immunoglobulin and leucine rich repeat domains 1
    synaptic adhesion-like molecule 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024509.1NP_078785.1  leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor

      See identical proteins and their annotated locations for NP_078785.1

      Status: VALIDATED

      Source sequence(s)
      BC003578
      Consensus CDS
      CCDS12483.1
      UniProtKB/Swiss-Prot
      Q9BTN0
      Related
      ENSP00000246529.3, ENST00000246529.3
      Conserved Domains (8) summary
      smart00410
      Location:302383
      IG_like; Immunoglobulin like
      cd00116
      Location:63168
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:242253
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:6384
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00041
      Location:424502
      fn3; Fibronectin type III domain
      pfam13855
      Location:59119
      LRR_8; Leucine rich repeat
      cl11960
      Location:310383
      Ig; Immunoglobulin domain
      cl15307
      Location:249281
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      35937120..35945195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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