Evl Enah/Vasp-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Evlprovided by RGD
Official Full Name: Enah/Vasp-likeprovided by RGD
Primary source: RGD:621150
See related: Ensembl:ENSRNOG00000014476 AllianceGenome:RGD:621150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable SH3 domain binding activity and profilin binding activity. Predicted to be involved in several processes, including actin polymerization or depolymerization; negative regulation of ruffle assembly; and positive regulation of supramolecular fiber organization. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in focal adhesion; lamellipodium; and phagocytic vesicle. Orthologous to human EVL (Enah/Vasp-like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 277.2), Spleen (RPKM 181.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (133238547..133358730)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (127473119..127594342)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (132470283..132590242)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that expression of spermiation-related genes is directly up-regulated by estrogen 17-beta-estradiol in testes of adult rats; a functional estrogen response element lies upstream of Arpc1b and Evl genes. (Arpc1b = actin related protein 2-3 complex, subunit 1B; Evl = enabled-VASP-like protein)
Title: Direct regulation of genes involved in sperm release by estrogen and androgen through their receptors and coregulators.
Evl is coordinately regulated during actin remodeling in epithelial cells.
Title: Vinculin, VASP, and profilin are coordinately regulated during actin remodeling in epithelial cells, which requires de novo protein synthesis and protein kinase signal transduction pathways.
The possible link between the spectrin-based skeleton and actin via the EVL protein suggests a new way of integrating the spectrin-based skeleton in areas of dynamic actin reorganization.
Title: Spectrin interacts with EVL (Enabled/vasodilator-stimulated phosphoprotein-like protein), a protein involved in actin polymerization.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	ISS Inferred from Sequence or Structural Similarity more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables profilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables profilin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IEA Inferred from Electronic Annotation more info
involved_in actin polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in actin polymerization or depolymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon guidance	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ruffle assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ena/VASP-like protein

Names: Ena-vasodilator stimulated phosphoprotein; RNB6; ena/vasodilator-stimulated phosphoprotein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001414900.1 → NP_001401829.1 ena/VASP-like protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

F1M8I7

Related

ENSRNOP00000019584.4, ENSRNOT00000019583.4
NM_024147.3 → NP_077061.2 ena/VASP-like protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I5Y7H8, A6KBG4

Conserved Domains (2) summary

cd01207
Location:5 → 113

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:356 → 388

VASP_tetra; VASP tetramerisation domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

133238547..133358730

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262532.1 → XP_063118602.1 ena/VASP-like protein isoform X1

UniProtKB/Swiss-Prot

A0A0G2K217, O08719
XM_063262535.1 → XP_063118605.1 ena/VASP-like protein isoform X4
XM_063262536.1 → XP_063118606.1 ena/VASP-like protein isoform X5
XM_063262533.1 → XP_063118603.1 ena/VASP-like protein isoform X2
XM_063262534.1 → XP_063118604.1 ena/VASP-like protein isoform X3
XM_063262537.1 → XP_063118607.1 ena/VASP-like protein isoform X6

UniProtKB/TrEMBL

A0A8I6AH17
XM_063262538.1 → XP_063118608.1 ena/VASP-like protein isoform X7

UniProtKB/TrEMBL

A6KBG7