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    RAB7A RAB7A, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 7879, updated on 17-Oct-2021

    Summary

    Official Symbol
    RAB7Aprovided by HGNC
    Official Full Name
    RAB7A, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9788
    See related
    Ensembl:ENSG00000075785 MIM:602298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAB7; CMT2B; PRO2706
    Summary
    RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 104.7), fat (RPKM 97.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See RAB7A in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (128726183..128814798)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128445026..128533641)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribophorin I Neighboring gene POU class 5 homeobox 1 pseudogene 6 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 8 Neighboring gene ferritin heavy chain 1 pseudogene 4 Neighboring gene RNA, 7SL, cytoplasmic 698, pseudogene Neighboring gene ribosomal protein S15a pseudogene 16 Neighboring gene Sharpr-MPRA regulatory region 6458 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 17 Neighboring gene microRNA 12124

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RAB7A; predicted interaction to be relevant to vesicular transport/membrane trafficking PubMed
    env Depletion of Rab7A leads to the accumulation of HIV-1 gp160 in cells, which results in reduced production of HIV-1 particles and infectivity PubMed
    Nef nef Genome-wide shRNA screening identifies RAB7, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells PubMed
    nef Nef-triggered MHCII endocytosis requires Rab5 activity and lyst function, whereas lysosomal trafficking of internalized MHCII molecules requires Rab7 activity PubMed
    Pr55(Gag) gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed
    gag HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells PubMed
    gag HIV-1 Gag mainly remains in endosomes and co-localizes with endosomal protein Rab7 in the cycloheximide-treated cells PubMed
    Vif vif Depletion of RAB7A by siRNA results in partial recovery of HIV-1 Vif in the presence of APOL1, suggesting that Vif is partly degraded by a RAB7-dependent pathway PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of ras-related protein Rab-7a (Rab-7A) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    capsid gag Inhibition of endocytosis by siRNA-mediated depletion of EPS15, STX7, RAB7, and VAMP7 restores Gag/p24 expression in the presence of APOL1 PubMed
    reverse transcriptase gag-pol The highest RT activity is found in Rab11a compartments and Rab7a compartments in nontreated cells after 7 and 14 days of HIV-1 challenge, respectively, suggesting that the virus is mainly located in these endosomal compartments PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20819

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retromer complex binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in early endosome to late endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endocytosis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endosome to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermal growth factor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in multi-organism intercellular transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of exosomal secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of intralumenal vesicle formation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phagosome acidification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagosome maturation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phagosome-lysosome fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phagosome-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of exosomal secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of viral process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to lysosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein to membrane docking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in viral release from host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extrinsic component of lysosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosomal membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in melanosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in phagocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-7a
    Names
    RAB7, member RAS oncogene family
    Ras-associated protein RAB7
    NP_004628.4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008070.1 RefSeqGene

      Range
      5001..93663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_266

    mRNA and Protein(s)

    1. NM_004637.6NP_004628.4  ras-related protein Rab-7a

      See identical proteins and their annotated locations for NP_004628.4

      Status: REVIEWED

      Source sequence(s)
      AF498942, AK094449, AU122058, BC008721, CA748697
      Consensus CDS
      CCDS3052.1
      UniProtKB/Swiss-Prot
      P51149
      UniProtKB/TrEMBL
      A0A158RFU6
      Related
      ENSP00000265062.3, ENST00000265062.8
      Conserved Domains (1) summary
      cd01862
      Location:9179
      Rab7; Rab GTPase family 7 (Rab7)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      128726183..128814798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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