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    DAP3 death associated protein 3 [ Homo sapiens (human) ]

    Gene ID: 7818, updated on 17-Jun-2019

    Summary

    Official Symbol
    DAP3provided by HGNC
    Official Full Name
    death associated protein 3provided by HGNC
    Primary source
    HGNC:HGNC:2673
    See related
    Ensembl:ENSG00000132676 MIM:602074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAP-3; S29mt; MRPS29; MRP-S29; bMRP-10
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in lymph node (RPKM 26.0), appendix (RPKM 24.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See DAP3 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155687902..155739010)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155657693..155708801)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene gon-4 like pseudogene Neighboring gene YY1 associated protein 1 Neighboring gene small Cajal body-specific RNA 26A Neighboring gene uncharacterized LOC100505728 Neighboring gene misato family member 2, pseudogene Neighboring gene gon-4 like Neighboring gene small Cajal body-specific RNA 26B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of death associated protein 3 (DAP3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Mitochondrial translation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
    • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
    • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
      Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
    • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
      Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TRAIL signaling pathway, organism-specific biosystem
      TRAIL signaling pathway

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ12817, MGC126058, MGC126059, DKFZp686G12159

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrial translational elongation TAS
    Traceable Author Statement
    more info
     
    mitochondrial translational termination TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    28S ribosomal protein S29, mitochondrial
    Names
    ionizing radiation resistance conferring protein
    mitochondrial 28S ribosomal protein S29
    mitochondrial small ribosomal subunit protein mS29

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199849.1NP_001186778.1  28S ribosomal protein S29, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001186778.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' UTR, as compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AK225869, AK302281, AL162734, BC107487, BQ183744
      Consensus CDS
      CCDS1120.1
      UniProtKB/Swiss-Prot
      P51398
      Conserved Domains (1) summary
      pfam10236
      Location:99393
      DAP3; Mitochondrial ribosomal death-associated protein 3
    2. NM_001199850.1NP_001186779.1  28S ribosomal protein S29, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001186779.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the CDS, as compared to variant 2. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK298201, AK302281, AL162734, BQ183744
      Consensus CDS
      CCDS55646.1
      UniProtKB/Swiss-Prot
      P51398
      Related
      ENSP00000412605.2, ENST00000421487.6
      Conserved Domains (1) summary
      pfam10236
      Location:65359
      DAP3; Mitochondrial ribosomal death-associated protein 3
    3. NM_001199851.1NP_001186780.1  28S ribosomal protein S29, mitochondrial isoform 3

      See identical proteins and their annotated locations for NP_001186780.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame exon in the CDS, as compared to variant 2. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK298201, AK302281, AL162734, BQ183744
      Consensus CDS
      CCDS55647.1
      UniProtKB/Swiss-Prot
      P51398
      Related
      ENSP00000445003.1, ENST00000535183.5
      Conserved Domains (1) summary
      pfam10236
      Location:58352
      DAP3; Mitochondrial ribosomal death-associated protein 3
    4. NM_004632.4NP_004623.1  28S ribosomal protein S29, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_004623.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (1). Variants 1, 2 and 3 encode the same isoform 1.
      Source sequence(s)
      AL162734, BC107487, BQ183744
      Consensus CDS
      CCDS1120.1
      UniProtKB/Swiss-Prot
      P51398
      Related
      ENSP00000357320.5, ENST00000368336.10
      Conserved Domains (1) summary
      pfam10236
      Location:99393
      DAP3; Mitochondrial ribosomal death-associated protein 3
    5. NM_033657.2NP_387506.1  28S ribosomal protein S29, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_387506.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has an additional segment in the 5' UTR, as compared to variant 2. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AL162734, BC107488, BQ183744
      Consensus CDS
      CCDS1120.1
      UniProtKB/Swiss-Prot
      P51398
      Related
      ENSP00000341692.3, ENST00000343043.7
      Conserved Domains (1) summary
      pfam10236
      Location:99393
      DAP3; Mitochondrial ribosomal death-associated protein 3

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      155687902..155739010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024449697.1XP_024305465.1  28S ribosomal protein S29, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam10236
      Location:99393
      DAP3; Mitochondrial ribosomal death-associated protein 3
    2. XM_024449698.1XP_024305466.1  28S ribosomal protein S29, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam10236
      Location:99366
      DAP3; Mitochondrial ribosomal death-associated protein 3
    3. XM_017002291.1XP_016857780.1  28S ribosomal protein S29, mitochondrial isoform X3

      UniProtKB/Swiss-Prot
      P51398
      Conserved Domains (1) summary
      pfam10236
      Location:65359
      DAP3; Mitochondrial ribosomal death-associated protein 3
    4. XM_017002294.1XP_016857783.1  28S ribosomal protein S29, mitochondrial isoform X5

    5. XM_017002292.1XP_016857781.1  28S ribosomal protein S29, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      P51398
      Related
      ENSP00000476592.1, ENST00000471642.6
      Conserved Domains (1) summary
      pfam10236
      Location:58352
      DAP3; Mitochondrial ribosomal death-associated protein 3
    6. XM_017002295.1XP_016857784.1  28S ribosomal protein S29, mitochondrial isoform X6

      Conserved Domains (1) summary
      pfam10236
      Location:58325
      DAP3; Mitochondrial ribosomal death-associated protein 3
    7. XM_024449700.1XP_024305468.1  28S ribosomal protein S29, mitochondrial isoform X6

      Conserved Domains (1) summary
      pfam10236
      Location:58325
      DAP3; Mitochondrial ribosomal death-associated protein 3
    8. XM_017002289.1XP_016857778.1  28S ribosomal protein S29, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam10236
      Location:99366
      DAP3; Mitochondrial ribosomal death-associated protein 3
    9. XM_005245480.2XP_005245537.1  28S ribosomal protein S29, mitochondrial isoform X3

      See identical proteins and their annotated locations for XP_005245537.1

      UniProtKB/Swiss-Prot
      P51398
      Conserved Domains (1) summary
      pfam10236
      Location:65359
      DAP3; Mitochondrial ribosomal death-associated protein 3
    10. XM_005245481.2XP_005245538.1  28S ribosomal protein S29, mitochondrial isoform X4

      See identical proteins and their annotated locations for XP_005245538.1

      UniProtKB/Swiss-Prot
      P51398
      Conserved Domains (1) summary
      pfam10236
      Location:58352
      DAP3; Mitochondrial ribosomal death-associated protein 3
    11. XM_017002290.1XP_016857779.1  28S ribosomal protein S29, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam10236
      Location:99366
      DAP3; Mitochondrial ribosomal death-associated protein 3
    12. XM_017002293.1XP_016857782.1  28S ribosomal protein S29, mitochondrial isoform X4

      UniProtKB/Swiss-Prot
      P51398
      Conserved Domains (1) summary
      pfam10236
      Location:58352
      DAP3; Mitochondrial ribosomal death-associated protein 3
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