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    LAPTM5 lysosomal protein transmembrane 5 [ Homo sapiens (human) ]

    Gene ID: 7805, updated on 17-Jun-2024

    Summary

    Official Symbol
    LAPTM5provided by HGNC
    Official Full Name
    lysosomal protein transmembrane 5provided by HGNC
    Primary source
    HGNC:HGNC:29612
    See related
    Ensembl:ENSG00000162511 MIM:601476; AllianceGenome:HGNC:29612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLAST6
    Summary
    This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]
    Expression
    Broad expression in bone marrow (RPKM 488.0), lymph node (RPKM 349.3) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LAPTM5 in Genome Data Viewer
    Location:
    1p35.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (30732469..30757774, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (30584986..30610292, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (31205316..31230621, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 558 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31191909-31192484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 615 Neighboring gene matrilin 1 Neighboring gene MATN1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 617 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31205119-31205624 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31205625-31206130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:31206171-31206672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31212057-31212616 Neighboring gene uncharacterized LOC105378620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 621 Neighboring gene microRNA 4420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31223351-31223894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31223895-31224436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:31229428-31230224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 632 Neighboring gene Sharpr-MPRA regulatory region 12480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:31246183-31246683 Neighboring gene uncharacterized LOC105378621 Neighboring gene CRISPRi-validated cis-regulatory element chr1.4289 Neighboring gene CRISPRi-validated cis-regulatory element chr1.4291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:31260718-31261230 Neighboring gene Sharpr-MPRA regulatory region 4114 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:31277163-31277830 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:31277831-31278496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:31282779-31283279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31291425-31291931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31296724-31297226 Neighboring gene long intergenic non-protein coding RNA 1778

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of lysosomal protein transmembrane 5 (LAPTM5) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ61683, FLJ97251, MGC125860, MGC125861

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein sequestering activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to lysosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to tumor cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in induction of programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of B cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of autophagic cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of interleukin-2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of cytokine production involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of interleukin-12 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of lysosomal membrane permeability IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of receptor catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein targeting to lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lysosomal-associated transmembrane protein 5
    Names
    CD40-ligand-activated specific transcripts
    human retinoic acid-inducible E3 protein
    lysosomal associated multispanning membrane protein 5
    lysosomal multispanning membrane protein 5
    lysosomal-associated multitransmembrane protein 5
    retinoic acid-inducible E3 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006762.3NP_006753.1  lysosomal-associated transmembrane protein 5

      See identical proteins and their annotated locations for NP_006753.1

      Status: REVIEWED

      Source sequence(s)
      AL137857, BC106897, D42042
      Consensus CDS
      CCDS337.1
      UniProtKB/Swiss-Prot
      Q13240, Q13571, Q14698, Q3KP54
      UniProtKB/TrEMBL
      B4DLI5, D3DPN1, Q5TBB8
      Related
      ENSP00000294507.3, ENST00000294507.4
      Conserved Domains (1) summary
      pfam03821
      Location:28261
      Mtp; Golgi 4-transmembrane spanning transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      30732469..30757774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542098.3XP_011540400.1  lysosomal-associated transmembrane protein 5 isoform X1

      Conserved Domains (1) summary
      cl04276
      Location:30204
      Mtp; Golgi 4-transmembrane spanning transporter

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      30584986..30610292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338660.1XP_054194635.1  lysosomal-associated transmembrane protein 5 isoform X1