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    Ehmt1 euchromatic histone methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 77683, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ehmt1provided by MGI
    Official Full Name
    euchromatic histone methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1924933
    See related
    Ensembl:ENSMUSG00000036893 AllianceGenome:MGI:1924933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GLP; GLP1; KMT1D; mKIAA1876; D330003E03; Eu-HMTase1; 9230102N17Rik
    Summary
    Enables C2H2 zinc finger domain binding activity; histone methyltransferase activity (H3-K27 specific); and histone methyltransferase activity (H3-K9 specific). Involved in several processes, including macromolecule methylation; negative regulation of transcription, DNA-templated; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; forelimb; integumental system; nervous system; and respiratory system. Used to study Kleefstra syndrome 1. Human ortholog(s) of this gene implicated in Kleefstra syndrome and Kleefstra syndrome 1. Orthologous to human EHMT1 (euchromatic histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 26.6), whole brain E14.5 (RPKM 23.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ehmt1 in Genome Data Viewer
    Location:
    2 A3; 2 16.73 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24680781..24809658, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24790769..24919643, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 pseudogene Neighboring gene calcium channel, voltage-dependent, N type, alpha 1B subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24603469-24603689 Neighboring gene STARR-positive B cell enhancer mm9_chr2:24766046-24766347 Neighboring gene STARR-positive B cell enhancer ABC_E634 Neighboring gene arrestin domain containing 1 Neighboring gene zinc finger, MYND domain containing 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis. Demond H, et al. Genome Res, 2023 Jan. PMID 36690445, Free PMC Article
    2. GLP-1 rescued gestational diabetes mellitus-induced suppression of fetal thalamus development. You L, et al. J Biochem Mol Toxicol, 2023 Feb. PMID 36424357
    3. EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas. Negwer M, et al. Brain Struct Funct, 2020 Dec. PMID 32975655, Free PMC Article
    4. The Object Space Task reveals increased expression of cumulative memory in a mouse model of Kleefstra syndrome. Schut EHS, et al. Neurobiol Learn Mem, 2020 Sep. PMID 32531423
    5. Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype. Frega M, et al. Cell Rep, 2020 Jan 7. PMID 31914384

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GLP-1 rescued gestational diabetes mellitus-induced suppression of fetal thalamus development.
      Title: GLP-1 rescued gestational diabetes mellitus-induced suppression of fetal thalamus development.
    2. Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis.
      Title: Multi-omics analyses demonstrate a critical role for EHMT1 methyltransferase in transcriptional repression during oogenesis.
    3. Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFkappaB p50 recruitment.
      Title: Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFκB p50 recruitment.
    4. The histone H3 lysine 9 methyltransferase G9a/GLP complex activity is required for long-term consolidation of spatial memory in mice.
      Title: The histone H3 lysine 9 methyltransferase G9a/GLP complex activity is required for long-term consolidation of spatial memory in mice.
    5. EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas.
      Title: EHMT1 regulates Parvalbumin-positive interneuron development and GABAergic input in sensory cortical areas.
    6. Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency.
      Title: Context-Dependent Requirement of Euchromatic Histone Methyltransferase Activity during Reprogramming to Pluripotency.
    7. PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.
      Title: PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome.
    8. transcription factor Wiz recruits the histone methyltransferase Ehmt1 to Foxp3 Treg-specific demethylated regions.
      Title: Recruitment of Histone Methyltransferase Ehmt1 to Foxp3 TSDR Counteracts Differentiation of Induced Regulatory T Cells.
    9. the regulation of NRF1 transcriptional activity by CDK2 may allow the modulation of Ehmt1 expression, therefore controlling the dynamic methylation of H3K9 during meiotic prophase.
      Title: CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I.
    10. Primary cultures of cortical neuronal networks derived from Ehmt1+/- mice showed network bursts with lower frequency and longer duration compared to cultures from littermate controls. NMDAR/AMPAR ratio was significantly increased in cortical networks of Ehmt1+/- mice, due to increased NMDAR activity.
      Title: Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Gene trapped (1) 
    • Targeted (8)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables histone H3K27 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K9 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K9 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H3K9 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K9 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in facultative heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-lysine dimethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-lysine dimethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-lysine dimethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine monomethylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase EHMT1
    Names
    G9a-like protein 1
    euchromatic histone-lysine N-methyltransferase 1
    lysine N-methyltransferase 1D
    NP_001012536.2
    NP_001103156.1
    NP_001103157.1
    NP_766133.2
    XP_006498485.1
    XP_006498486.1
    XP_006498487.1
    XP_006498488.1
    XP_006498489.1
    XP_006498493.1
    XP_006498494.1
    XP_006498495.1
    XP_017174824.1
    XP_017174825.1
    XP_030108067.1
    XP_030108068.1
    XP_030108069.1
    XP_030108070.1
    XP_030108071.1
    XP_030108072.1
    XP_030108073.1
    XP_030108074.1
    XP_030108075.1
    XP_030108076.1
    XP_030108077.1
    XP_030108078.1
    XP_030108079.1
    XP_030108081.1
    XP_030108082.1
    XP_030108083.1
    XP_030108084.1
    XP_030108085.1
    XP_030108086.1
    XP_030108087.1
    XP_030108088.1
    XP_030108089.1
    XP_030108090.1
    XP_030108091.1
    XP_036018604.1
    XP_036018605.1
    XP_036018606.1
    XP_036018608.1
    XP_036018609.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012518.3 → NP_001012536.2  histone-lysine N-methyltransferase EHMT1 isoform 1

      See identical proteins and their annotated locations for NP_001012536.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL732525, BB621957, BC089302, DV649682
      Consensus CDS
      CCDS15740.1
      UniProtKB/Swiss-Prot
      A2AIS3, A2AIS4, Q5DW34, Q5EBR1, Q6PGM0
      UniProtKB/TrEMBL
      Z4YJZ7
      Related
      ENSMUSP00000119057.3, ENSMUST00000147147.8
      Conserved Domains (6) summary
      smart00248
      Location:772 → 798
      ANK; ankyrin repeats
      smart00317
      Location:1124 → 1246
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:798 → 924
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05033
      Location:1012 → 1116
      Pre-SET; Pre-SET motif
      pfam12796
      Location:808 → 901
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:803 → 834
      ANK; ANK repeat [structural motif]

    2. NM_001109686.2 → NP_001103156.1  histone-lysine N-methyltransferase EHMT1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL732525, BB621957, BC089302, DV649682
      Consensus CDS
      CCDS59634.1
      UniProtKB/TrEMBL
      Z4YJZ7
      Related
      ENSMUSP00000110075.3, ENSMUST00000114432.9
      Conserved Domains (6) summary
      smart00248
      Location:719 → 745
      ANK; ankyrin repeats
      smart00317
      Location:1071 → 1193
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:745 → 871
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05033
      Location:959 → 1063
      Pre-SET; Pre-SET motif
      pfam12796
      Location:755 → 848
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:750 → 781
      ANK; ANK repeat [structural motif]

    3. NM_001109687.2 → NP_001103157.1  histone-lysine N-methyltransferase EHMT1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AL732525, BB621957, BC056938, DV649682
      Consensus CDS
      CCDS59636.1
      UniProtKB/TrEMBL
      E9Q5A3
      Related
      ENSMUSP00000046077.6, ENSMUST00000046227.12
      Conserved Domains (6) summary
      smart00248
      Location:724 → 750
      ANK; ankyrin repeats
      smart00317
      Location:1076 → 1198
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:750 → 876
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05033
      Location:964 → 1068
      Pre-SET; Pre-SET motif
      pfam12796
      Location:760 → 853
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:755 → 786
      ANK; ANK repeat [structural motif]

    4. NM_172545.4 → NP_766133.2  histone-lysine N-methyltransferase EHMT1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK049454, AK086833, AL732525, BB621957, DV649682
      Consensus CDS
      CCDS59635.1
      UniProtKB/TrEMBL
      A0A0H2UH19, Z4YJZ7
      Related
      ENSMUSP00000100002.5, ENSMUST00000102938.10
      Conserved Domains (6) summary
      smart00248
      Location:765 → 791
      ANK; ankyrin repeats
      smart00317
      Location:1117 → 1239
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:791 → 917
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam05033
      Location:1005 → 1109
      Pre-SET; Pre-SET motif
      pfam12796
      Location:801 → 894
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:796 → 827
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      24680781..24809658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252227.2 → XP_030108087.1  histone-lysine N-methyltransferase EHMT1 isoform X34

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:695 → 921
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:746 → 777
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:751 → 844
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:977 → 1207
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    2. XM_030252218.2 → XP_030108078.1  histone-lysine N-methyltransferase EHMT1 isoform X23

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:712 → 938
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:763 → 794
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:768 → 861
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:994 → 1224
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    3. XM_030252223.2 → XP_030108083.1  histone-lysine N-methyltransferase EHMT1 isoform X27

      UniProtKB/TrEMBL
      H7CHP8
      Conserved Domains (4) summary
      PHA03095
      Location:710 → 936
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:761 → 792
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:766 → 859
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:992 → 1222
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    4. XM_030252210.2 → XP_030108070.1  histone-lysine N-methyltransferase EHMT1 isoform X9

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:758 → 984
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:809 → 840
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:814 → 907
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1040 → 1270
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    5. XM_030252226.2 → XP_030108086.1  histone-lysine N-methyltransferase EHMT1 isoform X32

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:696 → 922
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:747 → 778
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:752 → 845
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:978 → 1208
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    6. XM_030252224.2 → XP_030108084.1  histone-lysine N-methyltransferase EHMT1 isoform X29

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:703 → 929
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:754 → 785
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:759 → 852
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:985 → 1215
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    7. XM_030252229.2 → XP_030108089.1  histone-lysine N-methyltransferase EHMT1 isoform X36

      UniProtKB/TrEMBL
      E9Q5A3
      Conserved Domains (4) summary
      PHA03095
      Location:672 → 898
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:723 → 754
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:728 → 821
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:954 → 1184
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    8. XM_006498426.2 → XP_006498489.1  histone-lysine N-methyltransferase EHMT1 isoform X6

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:760 → 986
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:811 → 842
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:816 → 909
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1042 → 1272
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    9. XM_036162715.1 → XP_036018608.1  histone-lysine N-methyltransferase EHMT1 isoform X30

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (5) summary
      PHA03095
      Location:698 → 924
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:749 → 780
      ANK; ANK repeat [structural motif]
      cd10535
      Location:980 → 1210
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
      pfam12796
      Location:754 → 847
      Ank_2; Ankyrin repeats (3 copies)
      cd20905
      Location:460 → 590
      EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

    10. XM_006498432.2 → XP_006498495.1  histone-lysine N-methyltransferase EHMT1 isoform X20

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:715 → 941
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:766 → 797
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:771 → 864
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:997 → 1227
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    11. XM_030252217.1 → XP_030108077.1  histone-lysine N-methyltransferase EHMT1 isoform X21

      UniProtKB/TrEMBL
      H7CHP8
      Conserved Domains (4) summary
      PHA03095
      Location:713 → 939
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:764 → 795
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:769 → 862
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:995 → 1225
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    12. XM_017319336.1 → XP_017174825.1  histone-lysine N-methyltransferase EHMT1 isoform X28

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:705 → 931
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:756 → 787
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:761 → 854
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:987 → 1217
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    13. XM_030252228.1 → XP_030108088.1  histone-lysine N-methyltransferase EHMT1 isoform X35

      UniProtKB/TrEMBL
      E9Q5A3
      Conserved Domains (4) summary
      PHA03095
      Location:674 → 900
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:725 → 756
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:730 → 823
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:956 → 1186
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    14. XM_006498430.2 → XP_006498493.1  histone-lysine N-methyltransferase EHMT1 isoform X16

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:722 → 948
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:773 → 804
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:778 → 871
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1004 → 1234
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    15. XM_006498431.2 → XP_006498494.1  histone-lysine N-methyltransferase EHMT1 isoform X17

      UniProtKB/TrEMBL
      E9Q5A3
      Conserved Domains (4) summary
      PHA03095
      Location:720 → 946
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:771 → 802
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:776 → 869
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1002 → 1232
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    16. XM_006498422.2 → XP_006498485.1  histone-lysine N-methyltransferase EHMT1 isoform X1

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:768 → 994
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:819 → 850
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:824 → 917
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1050 → 1280
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    17. XM_030252216.2 → XP_030108076.1  histone-lysine N-methyltransferase EHMT1 isoform X22

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:713 → 939
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:764 → 795
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:769 → 862
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:995 → 1225
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    18. XM_030252208.2 → XP_030108068.1  histone-lysine N-methyltransferase EHMT1 isoform X7

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:759 → 985
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:810 → 841
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:815 → 908
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1041 → 1271
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    19. XM_030252225.2 → XP_030108085.1  histone-lysine N-methyltransferase EHMT1 isoform X31

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:697 → 923
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:748 → 779
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:753 → 846
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:979 → 1209
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    20. XM_030252219.2 → XP_030108079.1  histone-lysine N-methyltransferase EHMT1 isoform X24

      UniProtKB/TrEMBL
      H7CHP8
      Conserved Domains (4) summary
      PHA03095
      Location:712 → 938
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:763 → 794
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:768 → 861
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:994 → 1224
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    21. XM_030252207.2 → XP_030108067.1  histone-lysine N-methyltransferase EHMT1 isoform X5

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:760 → 986
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:811 → 842
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:816 → 909
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1042 → 1272
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    22. XM_006498423.3 → XP_006498486.1  histone-lysine N-methyltransferase EHMT1 isoform X2

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:767 → 993
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:818 → 849
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:823 → 916
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1049 → 1279
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    23. XM_030252221.2 → XP_030108081.1  histone-lysine N-methyltransferase EHMT1 isoform X25

      UniProtKB/TrEMBL
      H7CHP8
      Conserved Domains (4) summary
      PHA03095
      Location:711 → 937
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:762 → 793
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:767 → 860
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:993 → 1223
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    24. XM_036162716.1 → XP_036018609.1  histone-lysine N-methyltransferase EHMT1 isoform X33

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (5) summary
      PHA03095
      Location:695 → 921
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:746 → 777
      ANK; ANK repeat [structural motif]
      cd10535
      Location:977 → 1207
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
      pfam12796
      Location:751 → 844
      Ank_2; Ankyrin repeats (3 copies)
      cd20905
      Location:457 → 587
      EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

    25. XM_030252222.1 → XP_030108082.1  histone-lysine N-methyltransferase EHMT1 isoform X26

      UniProtKB/TrEMBL
      H7CHP8
      Conserved Domains (4) summary
      PHA03095
      Location:710 → 936
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:761 → 792
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:766 → 859
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:992 → 1222
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    26. XM_030252209.1 → XP_030108069.1  histone-lysine N-methyltransferase EHMT1 isoform X8

      UniProtKB/TrEMBL
      Z4YJZ7
      Related
      ENSMUSP00000088906.6, ENSMUST00000091348.11
      Conserved Domains (4) summary
      PHA03095
      Location:758 → 984
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:809 → 840
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:814 → 907
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1040 → 1270
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    27. XM_030252230.1 → XP_030108090.1  histone-lysine N-methyltransferase EHMT1 isoform X37

      UniProtKB/TrEMBL
      H7CHP8
      Conserved Domains (4) summary
      PHA03095
      Location:671 → 897
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:722 → 753
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:727 → 820
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:953 → 1183
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    28. XM_030252214.1 → XP_030108074.1  histone-lysine N-methyltransferase EHMT1 isoform X18

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:719 → 945
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:770 → 801
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:775 → 868
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1001 → 1231
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    29. XM_030252215.1 → XP_030108075.1  histone-lysine N-methyltransferase EHMT1 isoform X19

      UniProtKB/TrEMBL
      H7CHP8
      Conserved Domains (4) summary
      PHA03095
      Location:717 → 943
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:768 → 799
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:773 → 866
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:999 → 1229
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    30. XM_006498424.2 → XP_006498487.1  histone-lysine N-methyltransferase EHMT1 isoform X3

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:765 → 991
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:816 → 847
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:821 → 914
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1047 → 1277
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    31. XM_006498425.3 → XP_006498488.1  histone-lysine N-methyltransferase EHMT1 isoform X4

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:761 → 987
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:812 → 843
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:817 → 910
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1043 → 1273
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    32. XM_030252213.2 → XP_030108073.1  histone-lysine N-methyltransferase EHMT1 isoform X15

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:724 → 950
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:775 → 806
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:780 → 873
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1006 → 1236
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    33. XM_030252231.2 → XP_030108091.1  histone-lysine N-methyltransferase EHMT1 isoform X38

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:661 → 887
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:712 → 743
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:717 → 810
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:943 → 1173
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    34. XM_036162713.1 → XP_036018606.1  histone-lysine N-methyltransferase EHMT1 isoform X13

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (5) summary
      PHA03095
      Location:731 → 957
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:782 → 813
      ANK; ANK repeat [structural motif]
      cd10535
      Location:1013 → 1243
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
      pfam12796
      Location:787 → 880
      Ank_2; Ankyrin repeats (3 copies)
      cd20905
      Location:493 → 623
      EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

    35. XM_036162712.1 → XP_036018605.1  histone-lysine N-methyltransferase EHMT1 isoform X12

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (5) summary
      PHA03095
      Location:733 → 959
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:784 → 815
      ANK; ANK repeat [structural motif]
      cd10535
      Location:1015 → 1245
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
      pfam12796
      Location:789 → 882
      Ank_2; Ankyrin repeats (3 copies)
      cd20905
      Location:495 → 625
      EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

    36. XM_030252211.2 → XP_030108071.1  histone-lysine N-methyltransferase EHMT1 isoform X14

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:726 → 952
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:777 → 808
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:782 → 875
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1008 → 1238
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    37. XM_030252212.2 → XP_030108072.1  histone-lysine N-methyltransferase EHMT1 isoform X15

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:724 → 950
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:775 → 806
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:780 → 873
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1006 → 1236
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    38. XM_017319335.2 → XP_017174824.1  histone-lysine N-methyltransferase EHMT1 isoform X11

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (4) summary
      PHA03095
      Location:742 → 968
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:793 → 824
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:798 → 891
      Ank_2; Ankyrin repeats (3 copies)
      cd10535
      Location:1024 → 1254
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins

    39. XM_036162711.1 → XP_036018604.1  histone-lysine N-methyltransferase EHMT1 isoform X10

      UniProtKB/TrEMBL
      Z4YJZ7
      Conserved Domains (5) summary
      PHA03095
      Location:747 → 973
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:798 → 829
      ANK; ANK repeat [structural motif]
      cd10535
      Location:1029 → 1259
      SET_EHMT1; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins
      pfam12796
      Location:803 → 896
      Ank_2; Ankyrin repeats (3 copies)
      cd20905
      Location:509 → 639
      EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2

    RNA

    1. XR_003953746.2 RNA Sequence

    2. XR_374136.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DW34.2 GenPept UniProtKB/Swiss-Prot:Q5DW34

    Gene LinkOut

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