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    ZNF223 zinc finger protein 223 [ Homo sapiens (human) ]

    Gene ID: 7766, updated on 15-Jun-2019

    Summary

    Official Symbol
    ZNF223provided by HGNC
    Official Full Name
    zinc finger protein 223provided by HGNC
    Primary source
    HGNC:HGNC:13016
    See related
    Ensembl:ENSG00000178386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. The function of this protein has yet to be determined. [provided by RefSeq, Mar 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.4), urinary bladder (RPKM 1.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See ZNF223 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (44051372..44069902)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44556164..44572142)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372414 Neighboring gene zinc finger protein 222 Neighboring gene zinc finger protein 284 Neighboring gene RNA, U6 small nuclear 902, pseudogene Neighboring gene zinc finger protein 224 Neighboring gene uncharacterized LOC100379224

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein 223
    Names
    Homo sapiens zinc finger protein 223
    KRAB A domain

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034021.1 RefSeqGene

      Range
      5001..20984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_013361.6NP_037493.3  zinc finger protein 223

      See identical proteins and their annotated locations for NP_037493.3

      Status: VALIDATED

      Source sequence(s)
      AC092072, AF187989, BC022466, DR761157, HY311227
      Consensus CDS
      CCDS12635.1
      UniProtKB/Swiss-Prot
      Q9UK11
      Related
      ENSP00000401947.1, ENST00000434772.8
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:139380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:346366
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:294310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:218243
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      44051372..44069902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027258.1XP_016882747.1  zinc finger protein 223 isoform X1

      UniProtKB/Swiss-Prot
      Q9UK11
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:139380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:346366
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:294310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:218243
      zf-H2C2_2; Zinc-finger double domain
    2. XM_017027259.1XP_016882748.1  zinc finger protein 223 isoform X1

      UniProtKB/Swiss-Prot
      Q9UK11
      Conserved Domains (6) summary
      smart00349
      Location:867
      KRAB; krueppel associated box
      COG5048
      Location:139380
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:346366
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:294310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:847
      KRAB; KRAB box
      pfam13465
      Location:218243
      zf-H2C2_2; Zinc-finger double domain
    3. XM_017027260.2XP_016882749.1  zinc finger protein 223 isoform X2

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