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    ZBTB16 zinc finger and BTB domain containing 16 [ Homo sapiens (human) ]

    Gene ID: 7704, updated on 3-Apr-2024

    Summary

    Official Symbol
    ZBTB16provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 16provided by HGNC
    Primary source
    HGNC:HGNC:12930
    See related
    Ensembl:ENSG00000109906 MIM:176797; AllianceGenome:HGNC:12930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLZF; ZNF145
    Summary
    This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 27.9), ovary (RPKM 22.2) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    11q23.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (114059711..114256770)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (114070066..114267135)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113930433..114127492)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902760 Neighboring gene uncharacterized LOC124902759 Neighboring gene uncharacterized LOC124902761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113906845-113907785 Neighboring gene Sharpr-MPRA regulatory region 6346 Neighboring gene Sharpr-MPRA regulatory region 5585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113962252-113962768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113962769-113963283 Neighboring gene MPRA-validated peak1475 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114030299-114030800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114030801-114031300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114034953-114035454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114035455-114035954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3915 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114083238-114083738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114083739-114084239 Neighboring gene Sharpr-MPRA regulatory region 4637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114111177-114111676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114128337-114128865 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:114166597-114167097 Neighboring gene nicotinamide N-methyltransferase Neighboring gene uncharacterized LOC101928940 Neighboring gene uncharacterized LOC107984391

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of zinc finger and BTB domain containing 16 (ZBTB16) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cartilage development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic hindlimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in forelimb morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hemopoiesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in male germ-line stem cell asymmetric division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mesonephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in myeloid cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ossification involved in bone maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NK T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cartilage development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 16
    Names
    promyelocytic leukaemia zinc finger
    zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)
    zinc finger protein PLZF

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012140.2 RefSeqGene

      Range
      5136..202190
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018011.3NP_001018011.1  zinc finger and BTB domain-containing protein 16 isoform 1

      See identical proteins and their annotated locations for NP_001018011.1

      Status: REVIEWED

      Source sequence(s)
      AP002518, BC026902
      Consensus CDS
      CCDS8367.1
      UniProtKB/Swiss-Prot
      Q05516, Q8TAL4
      UniProtKB/TrEMBL
      A0A024R3C6
      Related
      ENSP00000376721.2, ENST00000392996.2
      Conserved Domains (4) summary
      COG5048
      Location:448622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:25125
      BTB; BTB/POZ domain
      cl28033
      Location:177327
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    2. NM_001354750.2NP_001341679.1  zinc finger and BTB domain-containing protein 16 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000908, AP002518, AP002755
      Consensus CDS
      CCDS8367.1
      UniProtKB/Swiss-Prot
      Q05516, Q8TAL4
      UniProtKB/TrEMBL
      A0A024R3C6
      Related
      ENSP00000507788.1, ENST00000684295.1
      Conserved Domains (4) summary
      COG5048
      Location:448622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:25125
      BTB; BTB/POZ domain
      cl28033
      Location:177327
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    3. NM_001354751.2NP_001341680.1  zinc finger and BTB domain-containing protein 16 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000908, AP002518, AP002755
      Consensus CDS
      CCDS8367.1
      UniProtKB/Swiss-Prot
      Q05516, Q8TAL4
      UniProtKB/TrEMBL
      A0A024R3C6
      Related
      ENSP00000508351.1, ENST00000683318.1
      Conserved Domains (4) summary
      COG5048
      Location:448622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:25125
      BTB; BTB/POZ domain
      cl28033
      Location:177327
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    4. NM_001354752.1NP_001341681.1  zinc finger and BTB domain-containing protein 16 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000908, AP002518, KU178401
      Consensus CDS
      CCDS91597.1
      UniProtKB/TrEMBL
      A0A0S2Z4J5
      Related
      ENSP00000507219.1, ENST00000682810.1
      Conserved Domains (4) summary
      COG5048
      Location:434593
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:491511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:25125
      BTB; BTB/POZ domain
      pfam09606
      Location:167327
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    5. NM_006006.6NP_005997.2  zinc finger and BTB domain-containing protein 16 isoform 1

      See identical proteins and their annotated locations for NP_005997.2

      Status: REVIEWED

      Source sequence(s)
      AP002518, BC029812, BM969145, BX648973
      Consensus CDS
      CCDS8367.1
      UniProtKB/Swiss-Prot
      Q05516, Q8TAL4
      UniProtKB/TrEMBL
      A0A024R3C6
      Related
      ENSP00000338157.4, ENST00000335953.9
      Conserved Domains (4) summary
      COG5048
      Location:448622
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:520540
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:25125
      BTB; BTB/POZ domain
      cl28033
      Location:177327
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      114059711..114256770
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271658.6XP_005271715.1  zinc finger and BTB domain-containing protein 16 isoform X1

      UniProtKB/TrEMBL
      Q71UL7
      Conserved Domains (4) summary
      smart00225
      Location:35106
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:406426
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:25106
      BTB; BTB/POZ domain
      pfam13912
      Location:460483
      zf-C2H2_6; C2H2-type zinc finger
    2. XM_047427563.1XP_047283519.1  zinc finger and BTB domain-containing protein 16 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      114070066..114267135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369889.1XP_054225864.1  zinc finger and BTB domain-containing protein 16 isoform X1

    2. XM_054369890.1XP_054225865.1  zinc finger and BTB domain-containing protein 16 isoform X2

    3. XM_054369888.1XP_054225863.1  zinc finger and BTB domain-containing protein 16 isoform X3

      UniProtKB/Swiss-Prot
      Q05516, Q8TAL4
      UniProtKB/TrEMBL
      A0A024R3C6