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    KLRG1 killer cell lectin like receptor G1 [ Homo sapiens (human) ]

    Gene ID: 10219, updated on 2-Oct-2018

    Summary

    Official Symbol
    KLRG1provided by HGNC
    Official Full Name
    killer cell lectin like receptor G1provided by HGNC
    Primary source
    HGNC:HGNC:6380
    See related
    Ensembl:ENSG00000139187 MIM:604874; Vega:OTTHUMG00000168277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2F1; MAFA; MAFA-L; CLEC15A; MAFA-2F1; MAFA-LIKE
    Summary
    Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules. [provided by RefSeq, Jun 2016]
    Expression
    Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.1) and 23 other tissues See more
    Orthologs

    Genomic context

    See KLRG1 in Genome Data Viewer
    Location:
    12p13.31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (8950044..9215657)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (9142137..9163343)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene alpha-2-macroglobulin like 1 Neighboring gene polyhomeotic homolog 1 Neighboring gene mannose-6-phosphate receptor, cation dependent Neighboring gene voltage dependent anion channel 2 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 612 Neighboring gene A2M antisense RNA 1 Neighboring gene alpha-2-macroglobulin Neighboring gene keratin 17 pseudogene 8 Neighboring gene BTG anti-proliferation factor 1 pseudogene 1 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 12 Neighboring gene PZP, alpha-2-macroglobulin like Neighboring gene microRNA 1244-3 Neighboring gene prothymosin alpha pseudogene 4 Neighboring gene alpha-2-macroglobulin pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC13600

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    killer cell lectin-like receptor subfamily G member 1
    Names
    C-type lectin domain family 15 member A
    ITIM-containing receptor MAFA-L
    MAFA-like receptor
    killer cell lectin-like receptor subfamily G, member 1
    mast cell function-associated antigen (ITIM-containing)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329099.1NP_001316028.1  killer cell lectin-like receptor subfamily G member 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC012621
      Consensus CDS
      CCDS86277.1
      UniProtKB/Swiss-Prot
      Q96E93
      Related
      ENSP00000266551.4, ENST00000266551.8
      Conserved Domains (1) summary
      cd03593
      Location:75186
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    2. NM_001329101.1NP_001316030.1  killer cell lectin-like receptor subfamily G member 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC006581, DT217650
    3. NM_001329102.1NP_001316031.1  killer cell lectin-like receptor subfamily G member 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC006581
    4. NM_001329103.1NP_001316032.1  killer cell lectin-like receptor subfamily G member 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC006581
    5. NM_005810.3NP_005801.3  killer cell lectin-like receptor subfamily G member 1 isoform b

      See identical proteins and their annotated locations for NP_005801.3

      Status: REVIEWED

      Source sequence(s)
      AF097358, AI433079, BC012621
      Consensus CDS
      CCDS8599.1
      UniProtKB/Swiss-Prot
      Q96E93
      Related
      ENSP00000349477.3, OTTHUMP00000238502, ENST00000356986.7, OTTHUMT00000399144
      Conserved Domains (1) summary
      cd03593
      Location:75186
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RNA

    1. NR_137426.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006581
    2. NR_137427.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006581, BQ212545
    3. NR_137428.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006581

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

      Range
      8950044..9215657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018685.1XP_016874174.1  killer cell lectin-like receptor subfamily G member 1 isoform X1

    2. XM_017018684.1XP_016874173.1  killer cell lectin-like receptor subfamily G member 1 isoform X1

    3. XM_017018683.1XP_016874172.1  killer cell lectin-like receptor subfamily G member 1 isoform X1

    4. XM_017018682.1XP_016874171.1  killer cell lectin-like receptor subfamily G member 1 isoform X1

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