Format

Send to:

Choose Destination
    • Showing Current items.

    VBP1 VHL binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 7411, updated on 5-Sep-2021

    Summary

    Official Symbol
    VBP1provided by HGNC
    Official Full Name
    VHL binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:12662
    See related
    Ensembl:ENSG00000155959 MIM:300133
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PFD3; PFDN3; VBP-1; HIBBJ46
    Summary
    The protein encoded by this gene interacts with the Von Hippel-Lindau protein to form an intracellular complex. The encoded protein functions as a chaperone protein, and may play a role in the transport of the Von Hippel-Lindau protein from the perinuclear granules to the nucleus or cytoplasm. Alternative splicing and the use of alternate transcription start sites results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in brain (RPKM 27.3), heart (RPKM 18.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See VBP1 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (155197007..155239841)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (154425284..154468122)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene BRCA1/BRCA2-containing complex subunit 3 Neighboring gene int1h-2 recombination region Neighboring gene Sharpr-MPRA regulatory region 7862 Neighboring gene RAB39B, member RAS oncogene family Neighboring gene chloride intracellular channel 2 Neighboring gene twinfilin 1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Systematic yeast two-hybrid screenings identify von Hippel-Lindau binding protein 1 (VBP1) as cellular binding partners of HIV-1 integrase PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with von Hippel-Lindau binding protein 1 (VBP1; PFD3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the VBP1 gene: The VBP1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
    • Orthologs from Annotation Pipeline: 385 organisms have orthologs with human gene VBP1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables amyloid-beta binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of amyloid fibril formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of polysome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of prefoldin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prefoldin subunit 3
    Names
    von Hippel-Lindau binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013269.2 RefSeqGene

      Range
      24454..47835
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001303543.1NP_001290472.1  prefoldin subunit 3 isoform 2

      See identical proteins and their annotated locations for NP_001290472.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) initiates transcription at an alternate position and has a longer 5' terminal exon than variant 1. It initiates translation at an alternate start codon and the encoded isoform (2) has a longer N-terminus than isoform 1.
      Source sequence(s)
      AA626259, BC009570, BX682237, U96759
      UniProtKB/Swiss-Prot
      P61758
      UniProtKB/TrEMBL
      D3DWY7
      Conserved Domains (1) summary
      pfam02996
      Location:96216
      Prefoldin; Prefoldin subunit
    2. NM_001303544.1NP_001290473.1  prefoldin subunit 3 isoform 3

      See identical proteins and their annotated locations for NP_001290473.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA626259, AK301646, BC009570
      Consensus CDS
      CCDS78525.1
      UniProtKB/TrEMBL
      B4DWR3
      Related
      ENSP00000438694.1, ENST00000535916.5
      Conserved Domains (1) summary
      cd00584
      Location:45176
      Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...
    3. NM_001303545.1NP_001290474.1  prefoldin subunit 3 isoform 4

      See identical proteins and their annotated locations for NP_001290474.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AA626259, BC009570, BC040002, DA610631
      UniProtKB/Swiss-Prot
      P61758
      UniProtKB/TrEMBL
      Q6FH24
      Conserved Domains (1) summary
      pfam02996
      Location:23143
      Prefoldin; Prefoldin subunit
    4. NM_003372.7NP_003363.1  prefoldin subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_003363.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AA626259, BC009570, BC046094, DA610631
      Consensus CDS
      CCDS14765.1
      UniProtKB/Swiss-Prot
      P61758
      Related
      ENSP00000286428.5, ENST00000286428.7
      Conserved Domains (1) summary
      pfam02996
      Location:60180
      Prefoldin; Prefoldin subunit

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

      Range
      155197007..155239841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center