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    UCP3 uncoupling protein 3 [ Homo sapiens (human) ]

    Gene ID: 7352, updated on 26-Sep-2021

    Summary

    Official Symbol
    UCP3provided by HGNC
    Official Full Name
    uncoupling protein 3provided by HGNC
    Primary source
    HGNC:HGNC:12519
    See related
    Ensembl:ENSG00000175564 MIM:602044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLC25A9
    Summary
    Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See UCP3 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (74000277..74009085, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73711322..73720130, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene family with sequence similarity 91 member A1 pseudogene Neighboring gene C2 domain containing 3 centriole elongation regulator Neighboring gene Sharpr-MPRA regulatory region 9619 Neighboring gene protein phosphatase methylesterase 1 Neighboring gene RNA, 5S ribosomal pseudogene 343

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of uncoupling protein 3 (UCP3, mitochondrial, proton carrier) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables oxidative phosphorylation uncoupler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adaptive thermogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proton transmembrane transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in respiratory gaseous exchange by respiratory system TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cold IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to superoxide IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    mitochondrial uncoupling protein 3
    Names
    solute carrier family 25 member 9
    uncoupling protein 3 (mitochondrial, proton carrier)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011515.1 RefSeqGene

      Range
      5153..13961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003356.4NP_003347.1  mitochondrial uncoupling protein 3 isoform UCP3L

      See identical proteins and their annotated locations for NP_003347.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (long) encodes the full length isoform.
      Source sequence(s)
      AP003717, AW295096, BC008392, BU618868, DA876282, U84763
      Consensus CDS
      CCDS8229.1
      UniProtKB/Swiss-Prot
      P55916
      UniProtKB/TrEMBL
      A0A0S2Z4G5
      Related
      ENSP00000323740.4, ENST00000314032.9
      Conserved Domains (2) summary
      PTZ00169
      Location:14302
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:112210
      Mito_carr; Mitochondrial carrier protein
    2. NM_022803.3NP_073714.1  mitochondrial uncoupling protein 3 isoform UCP3S

      See identical proteins and their annotated locations for NP_073714.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (short) encodes a protein which is different at the C-terminus from isoform UCP3L. It has an incomplete sixth transmembrane domain and an incomplete purine nucleotide binding domain.
      Source sequence(s)
      AP003717, DA876282, U82818
      Consensus CDS
      CCDS44677.1
      UniProtKB/Swiss-Prot
      P55916
      Related
      ENSP00000392143.2, ENST00000426995.2
      Conserved Domains (1) summary
      pfam00153
      Location:112210
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      74000277..74009085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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