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    UCP2 uncoupling protein 2 [ Homo sapiens (human) ]

    Gene ID: 7351, updated on 8-Jul-2019

    Summary

    Official Symbol
    UCP2provided by HGNC
    Official Full Name
    uncoupling protein 2provided by HGNC
    Primary source
    HGNC:HGNC:12518
    See related
    Ensembl:ENSG00000175567 MIM:601693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UCPH; BMIQ4; SLC25A8
    Summary
    Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lymph node (RPKM 136.6), spleen (RPKM 105.7) and 20 other tissues See more
    Orthologs

    Genomic context

    See UCP2 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (73974671..73982872, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73685716..73693889, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene proteasomal ATPase associated factor 1 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene family with sequence similarity 91 member A1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    oxidative phosphorylation uncoupler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adaptive thermogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    proton transmembrane transport TAS
    Traceable Author Statement
    more info
     
    response to cold IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    mitochondrial uncoupling protein 2
    Names
    solute carrier family 25 member 8
    uncoupling protein 2 (mitochondrial, proton carrier)

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011478.1 RefSeqGene

      Range
      5001..13174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003355.2NP_003346.2  mitochondrial uncoupling protein 2

      See identical proteins and their annotated locations for NP_003346.2

      Status: REVIEWED

      Source sequence(s)
      AF096289
      Consensus CDS
      CCDS8228.1
      UniProtKB/Swiss-Prot
      P55851
      UniProtKB/TrEMBL
      A0A024R5N5
      Related
      ENSP00000499695.1, ENST00000663595.1
      Conserved Domains (1) summary
      pfam00153
      Location:112206
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      73974671..73982872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448674.1XP_024304442.1  mitochondrial uncoupling protein 2 isoform X1

      Conserved Domains (2) summary
      pfam00153
      Location:113207
      Mito_carr; Mitochondrial carrier protein
      cl28162
      Location:42112
      Mito_carr; Mitochondrial carrier protein
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