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    UPK1B uroplakin 1B [ Homo sapiens (human) ]

    Gene ID: 7348, updated on 23-Nov-2021

    Summary

    Official Symbol
    UPK1Bprovided by HGNC
    Official Full Name
    uroplakin 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:12578
    See related
    Ensembl:ENSG00000114638 MIM:602380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UPIB; UPK1; TSPAN20
    Summary
    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in urinary bladder (RPKM 15.8), stomach (RPKM 12.4) and 5 other tissues See more
    Orthologs
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    Genomic context

    See UPK1B in Genome Data Viewer
    Location:
    3q13.32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (119173598..119205143)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (118892445..118923990)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily member 11 Neighboring gene Sharpr-MPRA regulatory region 3599 Neighboring gene testis expressed 55 Neighboring gene B4GALT4 antisense RNA 1 Neighboring gene beta-1,4-galactosyltransferase 4 Neighboring gene Rho GTPase activating protein 31 Neighboring gene ribosomal protein S26 pseudogene 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: TEX55

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    uroplakin-1b
    Names
    UP1b
    tetraspan
    tetraspanin-20
    tspan-20
    uroplakin Ib

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006952.4NP_008883.2  uroplakin-1b

      See identical proteins and their annotated locations for NP_008883.2

      Status: REVIEWED

      Source sequence(s)
      AB002155, AL709739
      Consensus CDS
      CCDS2985.1
      UniProtKB/Swiss-Prot
      O75841
      Related
      ENSP00000264234.3, ENST00000264234.8
      Conserved Domains (2) summary
      cd03156
      Location:118230
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:10258
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      119173598..119205143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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