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    SUMO1 small ubiquitin like modifier 1 [ Homo sapiens (human) ]

    Gene ID: 7341, updated on 11-Apr-2024

    Summary

    Official Symbol
    SUMO1provided by HGNC
    Official Full Name
    small ubiquitin like modifier 1provided by HGNC
    Primary source
    HGNC:HGNC:12502
    See related
    Ensembl:ENSG00000116030 MIM:601912; AllianceGenome:HGNC:12502
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAP1; GMP1; PIC1; SMT3; UBL1; OFC10; SENP2; SMT3C; SMT3H3
    Summary
    This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 51.9), adrenal (RPKM 51.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SUMO1 in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (202206171..202238597, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (202687204..202719634, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (203070894..203103320, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene KIAA2012 Neighboring gene proteasome subunit alpha 2 pseudogene 3 Neighboring gene DAZ associated protein 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12240 Neighboring gene short transmembrane mitochondrial protein 1 pseudogene Neighboring gene ribosomal protein L39 pseudogene 14 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:203114251-203114982 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:203114983-203115714 Neighboring gene NOP58 ribonucleoprotein Neighboring gene small nucleolar RNA, C/D box 70

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
    integrase gag-pol SUMOylation of HIV-1 IN at positions K46, K136, and K244 by SUMO involves HIV-1 infectivity PubMed
    gag-pol HIV-1 IN interacts with SUMO1/SUMO2 and Ubc9 in cells. Upregulations of SUMO1/SUMO2 and Ubc9 inhibit HIV-1 integration, while downregulations of SUMO1/SUMO2 and Ubc9 increase HIV-1 integration PubMed
    p6 gag HIV-1 p6 interacts with SUMO-1 through a covalent attachment of SUMO-1 to lysine 27 of p6, resulting in the incorporation of SUMO-1 into HIV-1 virions PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables potassium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables small protein activating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in PML body organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of action potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of delayed rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of negative regulation of transcription by transcription factor localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to nuclear pore IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cardiac muscle cell contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein localization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in roof of mouth development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    colocalizes_with PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in XY body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    part_of nuclear pore TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    small ubiquitin-related modifier 1
    Names
    GAP modifying protein 1
    SMT3 homolog 3
    SMT3 suppressor of mif two 3 homolog 1
    sentrin
    ubiquitin-homology domain protein PIC1
    ubiquitin-like protein SMT3C
    ubiquitin-like protein UBL1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011679.1 RefSeqGene

      Range
      5003..37418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001005781.2NP_001005781.1  small ubiquitin-related modifier 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001005781.1

      Status: REVIEWED

      Source sequence(s)
      AC079354
      Consensus CDS
      CCDS2352.1
      UniProtKB/Swiss-Prot
      A8MUS8, B2R4I5, P55856, P63165, Q6FGG0, Q6NZ62, Q93068
      UniProtKB/TrEMBL
      A0A5P8PBC0
      Related
      ENSP00000376076.1, ENST00000392245.5
      Conserved Domains (1) summary
      cd16114
      Location:2196
      Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins
    2. NM_001005782.2NP_001005782.1  small ubiquitin-related modifier 1 isoform b

      See identical proteins and their annotated locations for NP_001005782.1

      Status: REVIEWED

      Source sequence(s)
      AC079354
      Consensus CDS
      CCDS46493.1
      UniProtKB/TrEMBL
      B8ZZ67
      Related
      ENSP00000376075.3, ENST00000392244.7
      Conserved Domains (1) summary
      cd16114
      Location:471
      Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins
    3. NM_001371392.1NP_001358321.1  small ubiquitin-related modifier 1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC079354
      UniProtKB/TrEMBL
      A0A5P8PBC0
      Conserved Domains (1) summary
      cd16114
      Location:2095
      Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins
    4. NM_001371393.1NP_001358322.1  small ubiquitin-related modifier 1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC079354
      Consensus CDS
      CCDS92928.1
      UniProtKB/TrEMBL
      B9A032
      Related
      ENSP00000386296.1, ENST00000409712.5
      Conserved Domains (1) summary
      cl28922
      Location:2172
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    5. NM_001371394.1NP_001358323.1  small ubiquitin-related modifier 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC079354
      Consensus CDS
      CCDS92929.1
      UniProtKB/TrEMBL
      B8ZZN6
      Related
      ENSP00000387204.1, ENST00000409368.5
      Conserved Domains (1) summary
      cd16114
      Location:21141
      Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins
    6. NM_003352.8NP_003343.1  small ubiquitin-related modifier 1 isoform a precursor

      See identical proteins and their annotated locations for NP_003343.1

      Status: REVIEWED

      Source sequence(s)
      AC079354
      Consensus CDS
      CCDS2352.1
      UniProtKB/Swiss-Prot
      A8MUS8, B2R4I5, P55856, P63165, Q6FGG0, Q6NZ62, Q93068
      UniProtKB/TrEMBL
      A0A5P8PBC0
      Related
      ENSP00000376077.2, ENST00000392246.7
      Conserved Domains (1) summary
      cd16114
      Location:2196
      Ubl_SUMO1; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO-1) and similar proteins

    RNA

    1. NR_163943.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC079354

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      202206171..202238597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      202687204..202719634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)