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    UBE2I ubiquitin conjugating enzyme E2 I [ Homo sapiens (human) ]

    Gene ID: 7329, updated on 8-Dec-2022

    Summary

    Official Symbol
    UBE2Iprovided by HGNC
    Official Full Name
    ubiquitin conjugating enzyme E2 Iprovided by HGNC
    Primary source
    HGNC:HGNC:12485
    See related
    Ensembl:ENSG00000103275 MIM:601661; AllianceGenome:HGNC:12485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P18; UBC9; C358B7.1
    Summary
    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 23.2), endometrium (RPKM 17.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See UBE2I in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1309152..1327017)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1325332..1343194)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1359153..1377018)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene tryptase pseudogene 2 Neighboring gene uncharacterized LOC124903624 Neighboring gene ribosomal protein S20 pseudogene 2 Neighboring gene BAI1 associated protein 3 Neighboring gene TSR3 ribosome maturation factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Levels of HIV-1 gp120 and Endo Hf-resistant gp120 are reduced in the absence of UBC9 expression. Degradation of gp120 occurs before transport to the plasma membrane and the lipid rafts in the UBC9 knockdown cells PubMed
    env UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into virions PubMed
    Envelope transmembrane glycoprotein gp41 env UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into released virions PubMed
    Pr55(Gag) gag HIV-1 Gag trafficking and association with the plasma membrane is altered in the absebce of UBC9 PubMed
    gag UBC9 contributes to viral glycoproteins gp120/gp41 stability in the presence of Gag expression and affects incorporation of the gp120/gp41 into released virions PubMed
    gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
    gag Coimmunoprecipitation shows that HIV-1 Gag and human UBC9 interact in vivo. HIV-1 Gag and human UBC9 colocalize in HIV-1-expressing cells PubMed
    integrase gag-pol HIV-1 IN interacts with SUMO1/SUMO2 and Ubc9 in cells. Upregulations of SUMO1/SUMO2 and Ubc9 inhibit HIV-1 integration, while downregulations of SUMO1/SUMO2 and Ubc9 increase HIV-1 integration PubMed
    p6 gag HIV-1 p6 interacts with Ubc9 in a yeast two-hybrid system PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables HLH domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RING-like zinc finger domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables SUMO conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SUMO conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables SUMO transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables SUMO transferase activity TAS
    Traceable Author Statement
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small protein activating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic nuclear membrane reassembly TAS
    Traceable Author Statement
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
     
    involved_in nuclear export EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of SUMO transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein sumoylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein sumoylation TAS
    Traceable Author Statement
    more info
     
    involved_in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SUMO ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
     
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synaptonemal complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of transferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    SUMO-conjugating enzyme UBC9
    Names
    RING-type E3 SUMO transferase UBC9
    SUMO-1-protein ligase
    SUMO-protein ligase
    ubiquitin carrier protein 9
    ubiquitin carrier protein I
    ubiquitin conjugating enzyme 9
    ubiquitin conjugating enzyme E2I
    ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
    ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)
    ubiquitin-conjugating enzyme UbcE2A
    ubiquitin-like protein SUMO-1 conjugating enzyme
    ubiquitin-protein ligase E2I
    ubiquitin-protein ligase I
    NP_003336.1
    NP_919235.1
    NP_919236.1
    NP_919237.1
    XP_005255597.1
    XP_011520946.1
    XP_011520947.1
    XP_047290540.1
    XP_047290541.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003345.5NP_003336.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_003336.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AK291118, AL031714, BC000427, BI793063
      Consensus CDS
      CCDS10433.1
      UniProtKB/Swiss-Prot
      P63279, Q86VB3
      UniProtKB/TrEMBL
      A8K503
      Related
      ENSP00000380649.3, ENST00000397514.8
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    2. NM_194259.3NP_919235.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_919235.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AK291118, AL031714, BF315618, BI793063, D45050
      Consensus CDS
      CCDS10433.1
      UniProtKB/Swiss-Prot
      P63279, Q86VB3
      UniProtKB/TrEMBL
      A8K503
      Related
      ENSP00000380650.2, ENST00000397515.6
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    3. NM_194260.3NP_919236.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_919236.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AC120498, AL031714, BI793063, CX788607
      Consensus CDS
      CCDS10433.1
      UniProtKB/Swiss-Prot
      P63279, Q86VB3
      Related
      ENSP00000348056.4, ENST00000355803.8
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    4. NM_194261.3NP_919237.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_919237.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, as compared to variant 1.
      Source sequence(s)
      AB208988, AC120498, AL031714, BI793063
      Consensus CDS
      CCDS10433.1
      UniProtKB/Swiss-Prot
      P63279, Q86VB3
      Related
      ENSP00000324897.5, ENST00000325437.9
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      1309152..1327017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434585.1XP_047290541.1  SUMO-conjugating enzyme UBC9 isoform X1

      UniProtKB/TrEMBL
      B0QYN7
    2. XM_011522645.2XP_011520947.1  SUMO-conjugating enzyme UBC9 isoform X1

      See identical proteins and their annotated locations for XP_011520947.1

      UniProtKB/TrEMBL
      B0QYN7
      Conserved Domains (2) summary
      COG5078
      Location:1137
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:8137
      UQ_con; Ubiquitin-conjugating enzyme
    3. XM_047434584.1XP_047290540.1  SUMO-conjugating enzyme UBC9 isoform X1

      UniProtKB/TrEMBL
      B0QYN7
      Related
      ENSP00000384361.1, ENST00000402301.5
    4. XM_011522644.3XP_011520946.1  SUMO-conjugating enzyme UBC9 isoform X1

      See identical proteins and their annotated locations for XP_011520946.1

      UniProtKB/TrEMBL
      B0QYN7
      Conserved Domains (2) summary
      COG5078
      Location:1137
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:8137
      UQ_con; Ubiquitin-conjugating enzyme
    5. XM_005255540.3XP_005255597.1  SUMO-conjugating enzyme UBC9 isoform X1

      See identical proteins and their annotated locations for XP_005255597.1

      UniProtKB/TrEMBL
      B0QYN7
      Conserved Domains (2) summary
      COG5078
      Location:1137
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:8137
      UQ_con; Ubiquitin-conjugating enzyme

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      1325332..1343194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)