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    RGPD2 RANBP2 like and GRIP domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 729857, updated on 15-Jun-2019

    Summary

    Official Symbol
    RGPD2provided by HGNC
    Official Full Name
    RANBP2 like and GRIP domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:32415
    See related
    Ensembl:ENSG00000185304 MIM:612705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGP2; NUP358; RANBP2L2
    Expression
    Broad expression in testis (RPKM 17.3), placenta (RPKM 6.4) and 23 other tissues See more

    Genomic context

    See RGPD2 in Genome Data Viewer
    Location:
    2p11.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (87757198..87992819, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (88056717..88125331, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928214 Neighboring gene anaphase promoting complex subunit 1 pseudogene Neighboring gene plasminogen like B2 Neighboring gene MT-ATP6 pseudogene 28 Neighboring gene MT-ATP8 pseudogene 2 Neighboring gene uncharacterized LOC105374851 Neighboring gene anaphase promoting complex subunit 1 pseudogene Neighboring gene WW domain binding protein 1 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 7 Neighboring gene lysine-rich coiled-coil 1 pseudogene Neighboring gene uncharacterized LOC105374852 Neighboring gene RNA, U2 small nuclear 63, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Nuclear pore complex, organism-specific biosystem (from KEGG)
      Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Nuclear pore complex, conserved biosystem (from KEGG)
      Nuclear pore complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ56975

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Ran GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    RANBP2-like and GRIP domain-containing protein 2
    Names
    Ran binding protein 2-like 2
    nucleoporin
    ran-binding protein 2-like 2
    ranBP2-like 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001078170.2NP_001071638.2  RANBP2-like and GRIP domain-containing protein 2

      See identical proteins and their annotated locations for NP_001071638.2

      Status: VALIDATED

      Source sequence(s)
      AC093616, AK302429, AY354203
      Consensus CDS
      CCDS42710.2
      UniProtKB/Swiss-Prot
      P0DJD1
      UniProtKB/TrEMBL
      B4DYH0
      Related
      ENSP00000381214.3, ENST00000398146.4
      Conserved Domains (8) summary
      smart00028
      Location:5990
      TPR; Tetratricopeptide repeats
      COG5171
      Location:9681160
      YRB1; Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]
      cd13177
      Location:10441160
      RanBD2_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 2
      cd14685
      Location:13411457
      RanBD3_RanBP2-like; Ran-binding protein 2, Ran binding domain repeat 3
      sd00006
      Location:5888
      TPR; TPR repeat [structural motif]
      pfam01465
      Location:16981740
      GRIP; GRIP domain
      pfam13414
      Location:58125
      TPR_11; TPR repeat
      pfam16704
      Location:16341694
      Rab_bind; Rab binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      87757198..87992819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004845.1XP_016860334.1  RANBP2-like and GRIP domain-containing protein 2 isoform X1

    2. XM_017004847.1XP_016860336.1  RANBP2-like and GRIP domain-containing protein 2 isoform X3

    3. XM_017004846.1XP_016860335.1  RANBP2-like and GRIP domain-containing protein 2 isoform X2

    4. XM_017004850.1XP_016860339.1  RANBP2-like and GRIP domain-containing protein 2 isoform X6

    5. XM_017004849.1XP_016860338.1  RANBP2-like and GRIP domain-containing protein 2 isoform X5

    6. XM_017004848.1XP_016860337.1  RANBP2-like and GRIP domain-containing protein 2 isoform X4

    RNA

    1. XR_001738923.2 RNA Sequence

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