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    CCR2 C-C motif chemokine receptor 2 [ Homo sapiens (human) ]

    Gene ID: 729230, updated on 24-Dec-2019

    Summary

    Official Symbol
    CCR2provided by HGNC
    Official Full Name
    C-C motif chemokine receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:1603
    See related
    Ensembl:ENSG00000121807 MIM:601267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2
    Summary
    The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]
    Expression
    Biased expression in appendix (RPKM 15.2), lymph node (RPKM 5.1) and 12 other tissues See more
    Orthologs

    Genomic context

    See CCR2 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (46353744..46360940)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46395235..46402413)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 3 Neighboring gene ubiquinol-cytochrome c reductase core protein 2 pseudogene 1 Neighboring gene CCR5 antisense RNA Neighboring gene C-C motif chemokine receptor 5 (gene/pseudogene) Neighboring gene C-C motif chemokine receptor like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
    NHGRI GWA Catalog
    Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
    NHGRI GWA Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV/tuberculosis coinfection upregulates CCR2 expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with only tuberculosis) PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of the resting CD4+ T cells with HIV-1 clade B Tat, but not clade C Tat, increases surface CXCR4 expression, which leads to increased function of CXCR4 including increased chemoattraction toward CXCR4-using-gp120 PubMed
    env Macrophage-tropic HIV-1 can use CCR2b, and to a lesser extent CCR3, STRL33, and APJ, to infect cells; the V1/2 region of HIV-1 gp120 plays a more important role in governing the use of CCR2b, CCR3, STRL33, and APJ than for CXCR4 PubMed
    env HIV-1 gp120 from CXCR4-tropic subtype E viruses isolated in Thailand associates with and uses at least one of the following coreceptors for virus entry: CCR8, CCR1, CCR2b, or CX3CR1 PubMed
    Nef nef HIV-1 Nef induces variable levels of CCR2 downregulation in different cell types PubMed
    Tat tat HIV-1 Tat upregulates the expression of CCR2,CD16, and TLR-4 in monocyte-derived macrophages PubMed
    tat HIV-1 clade B Tat, but not clade C Tat, increases CXCR4 surface expression on resting CD4+ T cells through a CCR2b-dependent mechanism that does not involve de novo protein synthesis PubMed
    tat HIV-1 Tat induces CCR2-mediated glial activation PubMed
    tat Results from the treatment of microglia with HIV-1 Tat suggest downregulation of CCR2 mRNA expression by HIV-1 Tat, however this was deemed to not be significant PubMed
    tat HIV-1 Tat binds to CCR2 and displaces MCP-1 from this beta-chemokine receptor, an effect mediated by Tat amino acids 24-51 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ78302, MGC103828, MGC111760, MGC168006

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C-C chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    C-C chemokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    CCR2 chemokine receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemokine (C-C motif) ligand 12 binding IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine (C-C motif) ligand 2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine (C-C motif) ligand 7 binding IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    JAK-STAT cascade TAS
    Traceable Author Statement
    more info
    PubMed 
    T-helper 17 cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    blood vessel remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular defense response IEA
    Inferred from Electronic Annotation
    more info
     
    cellular homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chemokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    dendritic cell chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    homeostasis of number of cells within a tissue IEA
    Inferred from Electronic Annotation
    more info
     
    humoral immune response IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inflammatory response to wounding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    leukocyte adhesion to vascular endothelial cell IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    monocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    monocyte extravasation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of adenylate cyclase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of eosinophil degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of type 2 immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neutrophil clearance IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of CD8-positive, alpha-beta T cell extravasation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of NMDA glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T-helper 1 type immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of alpha-beta T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of astrocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of hematopoietic stem cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of immune complex clearance by monocytes and macrophages ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interferon-gamma production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of leukocyte tethering or rolling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of monocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of monocyte chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of monocyte extravasation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of thymocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of tumor necrosis factor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of T cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of vascular endothelial growth factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to wounding TAS
    Traceable Author Statement
    more info
    PubMed 
    sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    C-C chemokine receptor type 2
    Names
    MCP-1 receptor
    chemokine (C-C motif) receptor 2
    monocyte chemoattractant protein 1 receptor
    monocyte chemotactic protein 1 receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021428.1 RefSeqGene

      Range
      5001..12179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001123041.2NP_001116513.2  C-C chemokine receptor type 2 isoform A

      See identical proteins and their annotated locations for NP_001116513.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AV715904, BC126452, BQ027284, BX101672, DC401093, DC418358
      Consensus CDS
      CCDS43078.1
      UniProtKB/Swiss-Prot
      P41597
      Related
      ENSP00000292301.3, ENST00000292301.4
      Conserved Domains (1) summary
      cd15184
      Location:43316
      7tmA_CCR5_CCR2; CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001123396.3NP_001116868.1  C-C chemokine receptor type 2 isoform B

      See identical proteins and their annotated locations for NP_001116868.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (B) differs in the 3' UTR and 3' coding region, compared to variant A. The resulting isoform (B) is shorter and contains a distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC098613, AC138069
      Consensus CDS
      CCDS46813.1
      UniProtKB/Swiss-Prot
      P41597
      UniProtKB/TrEMBL
      A0A024R2Q0
      Related
      ENSP00000399285.2, ENST00000445132.2
      Conserved Domains (2) summary
      pfam00001
      Location:59305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam06417
      Location:245283
      DUF1077; Protein of unknown function (DUF1077)

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      46353744..46360940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534069.1XP_011532371.1  C-C chemokine receptor type 2 isoform X1

      See identical proteins and their annotated locations for XP_011532371.1

      UniProtKB/Swiss-Prot
      P41597
      UniProtKB/TrEMBL
      A0A024R2Q0
      Conserved Domains (2) summary
      pfam00001
      Location:59305
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam06417
      Location:245283
      DUF1077; Protein of unknown function (DUF1077)
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