Format

Send to:

Choose Destination
    • Showing Current items.

    KRTAP4-8 keratin associated protein 4-8 [ Homo sapiens (human) ]

    Gene ID: 728224, updated on 17-Jun-2019

    Summary

    Official Symbol
    KRTAP4-8provided by HGNC
    Official Full Name
    keratin associated protein 4-8provided by HGNC
    Primary source
    HGNC:HGNC:17230
    See related
    Ensembl:ENSG00000204880
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAP4.8; KRTAP4.8
    Orthologs

    Genomic context

    See KRTAP4-8 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41096981..41098142, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39253233..39254375, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin associated protein 2-5, pseudogene Neighboring gene keratin associated protein 4-7 Neighboring gene keratin associated protein 4-16 Neighboring gene keratin associated protein 4-9

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Keratinization, organism-specific biosystem (from REACTOME)
      Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hair cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    keratinization TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    keratin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    keratin-associated protein 4-8
    Names
    keratin associated protein 4.8
    ultrahigh sulfur keratin-associated protein 4.8

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001322457.1NP_001309386.1  keratin-associated protein 4-8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents an alternate allele located on the reference alternate locus, ALT_REF_LOCI_1.
      Source sequence(s)
      AC037482
      UniProtKB/TrEMBL
      A0A0G2JLE6
      Conserved Domains (2) summary
      pfam01500
      Location:5114
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam13885
      Location:69113
      Keratin_B2_2; Keratin, high sulfur B2 protein
    2. NM_031960.3NP_114166.1  keratin-associated protein 4-8 isoform 1

      See identical proteins and their annotated locations for NP_114166.1

      Status: VALIDATED

      Source sequence(s)
      AC100808
      Consensus CDS
      CCDS45674.1
      UniProtKB/Swiss-Prot
      Q9BYQ9
      Related
      ENSP00000328444.4, ENST00000333822.4
      Conserved Domains (2) summary
      pfam01500
      Location:42184
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam13885
      Location:59103
      Keratin_B2_2; Keratin, high sulfur B2 protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      41096981..41098142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p13 ALT_REF_LOCI_1

    Genomic

    1. NW_003871091.1 Reference GRCh38.p13 ALT_REF_LOCI_1

      Range
      246639..247812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center