Format

Send to:

Choose Destination
    • Showing Current items.

    Arhgef10l Rho guanine nucleotide exchange factor (GEF) 10-like [ Mus musculus (house mouse) ]

    Gene ID: 72754, updated on 30-Apr-2019

    Summary

    Official Symbol
    Arhgef10lprovided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor (GEF) 10-likeprovided by MGI
    Primary source
    MGI:MGI:1920004
    See related
    Ensembl:ENSMUSG00000040964
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810441C07Rik
    Expression
    Ubiquitous expression in colon adult (RPKM 18.8), ovary adult (RPKM 14.6) and 27 other tissues See more
    Orthologs

    Genomic context

    See Arhgef10l in Genome Data Viewer
    Location:
    4; 4 D3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (140514485..140665905, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (140070400..140221820, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene 13017 Neighboring gene predicted gene 13021 Neighboring gene predicted gene, 42335 Neighboring gene predicted gene 13025 Neighboring gene regulator of chromosome condensation 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Rho guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    SREBP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 10-like protein
    Names
    GrinchGEF

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112722.1NP_001106193.1  rho guanine nucleotide exchange factor 10-like protein isoform b

      See identical proteins and their annotated locations for NP_001106193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame exon in the 5' coding region, compared to variant 4. It encodes isoform b, which is shorter than isoform d.
      Source sequence(s)
      AK028570, AK028648, AL954710, BC059220, BY026313
      Consensus CDS
      CCDS51343.1
      UniProtKB/Swiss-Prot
      A2AWP8
      Related
      ENSMUSP00000066249.5, ENSMUST00000069623.11
      Conserved Domains (2) summary
      pfam00621
      Location:283461
      RhoGEF; RhoGEF domain
      cl02567
      Location:8841009
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001112723.1NP_001106194.1  rho guanine nucleotide exchange factor 10-like protein isoform c

      See identical proteins and their annotated locations for NP_001106194.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the 5' coding region, compared to variant 4. It encodes isoform c, which is shorter than isoform d.
      Source sequence(s)
      AK028648, AK129408, BC059220
      Consensus CDS
      CCDS51342.1
      UniProtKB/Swiss-Prot
      A2AWP8
      Related
      ENSMUSP00000095431.2, ENSMUST00000097820.8
      Conserved Domains (2) summary
      pfam00621
      Location:283461
      RhoGEF; RhoGEF domain
      cl02567
      Location:8791004
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001290803.1NP_001277732.1  rho guanine nucleotide exchange factor 10-like protein isoform d

      See identical proteins and their annotated locations for NP_001277732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      BB612864, BB842000, BC059220, BQ558784, BX516814, CA751244, CF531696, CF532111, CX564261
      Consensus CDS
      CCDS71507.1
      UniProtKB/Swiss-Prot
      A2AWP8
      Conserved Domains (2) summary
      pfam00621
      Location:322500
      RhoGEF; RhoGEF domain
      cl02567
      Location:9231048
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_172415.3NP_766003.3  rho guanine nucleotide exchange factor 10-like protein isoform a

      See identical proteins and their annotated locations for NP_766003.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 4. It encodes isoform a, which is shorter than isoform d.
      Source sequence(s)
      AK129408, BC059220, CF532111
      Consensus CDS
      CCDS51344.1
      UniProtKB/Swiss-Prot
      A2AWP8
      Related
      ENSMUSP00000040531.3, ENSMUST00000039204.9
      Conserved Domains (2) summary
      pfam00621
      Location:322500
      RhoGEF; RhoGEF domain
      cl02567
      Location:9181043
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      140514485..140665905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539202.1XP_006539265.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      See identical proteins and their annotated locations for XP_006539265.1

      UniProtKB/Swiss-Prot
      A2AWP8
      Related
      ENSMUSP00000101425.1, ENSMUST00000105799.7
      Conserved Domains (2) summary
      pfam00621
      Location:322500
      RhoGEF; RhoGEF domain
      cl02567
      Location:9231048
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006539201.3XP_006539264.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      See identical proteins and their annotated locations for XP_006539264.1

      UniProtKB/Swiss-Prot
      A2AWP8
      Conserved Domains (2) summary
      pfam00621
      Location:322500
      RhoGEF; RhoGEF domain
      cl02567
      Location:9231048
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_017320396.1XP_017175885.1  rho guanine nucleotide exchange factor 10-like protein isoform X2

      UniProtKB/Swiss-Prot
      A2AWP8
      Conserved Domains (2) summary
      pfam00621
      Location:322500
      RhoGEF; RhoGEF domain
      cl02567
      Location:9231048
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_011250337.2XP_011248639.1  rho guanine nucleotide exchange factor 10-like protein isoform X1

      See identical proteins and their annotated locations for XP_011248639.1

      UniProtKB/Swiss-Prot
      A2AWP8
      Conserved Domains (2) summary
      pfam00621
      Location:322500
      RhoGEF; RhoGEF domain
      cl02567
      Location:9231048
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_011250340.2XP_011248642.1  rho guanine nucleotide exchange factor 10-like protein isoform X3

      See identical proteins and their annotated locations for XP_011248642.1

      UniProtKB/Swiss-Prot
      A2AWP8
      Conserved Domains (2) summary
      pfam00621
      Location:283461
      RhoGEF; RhoGEF domain
      cl02567
      Location:8791004
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. XM_006539204.3XP_006539267.1  rho guanine nucleotide exchange factor 10-like protein isoform X4

      Related
      ENSMUSP00000101424.1, ENSMUST00000105798.7
      Conserved Domains (2) summary
      pfam00621
      Location:105283
      RhoGEF; RhoGEF domain
      cl02567
      Location:706831
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. XM_017320397.1XP_017175886.1  rho guanine nucleotide exchange factor 10-like protein isoform X5

      Related
      ENSMUSP00000101423.2, ENSMUST00000105797.8

    RNA

    1. XR_001784205.1 RNA Sequence

    2. XR_001784204.1 RNA Sequence

    3. XR_881437.2 RNA Sequence

    Support Center