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    DNAJC7 DnaJ heat shock protein family (Hsp40) member C7 [ Homo sapiens (human) ]

    Gene ID: 7266, updated on 17-Jun-2019

    Summary

    Official Symbol
    DNAJC7provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C7provided by HGNC
    Primary source
    HGNC:HGNC:12392
    See related
    Ensembl:ENSG00000168259 MIM:601964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DJ11; DJC7; TPR2; TTC2
    Summary
    This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in brain (RPKM 25.3), lymph node (RPKM 14.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See DNAJC7 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41976421..42021371, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40128439..40169715, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATP citrate lyase Neighboring gene tetratricopeptide repeat domain 25 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 17 open reading frame 113

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) at amino acid residues 11-12 and 435-436 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
      Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Constitutive Androstane Receptor Pathway, organism-specific biosystem (from WikiPathways)
      Constitutive Androstane Receptor Pathway, organism-specific biosystemThe Constitutive Androstane Receptor (CAR) is a nuclear receptor and functions as a sensor for xenobiotics. It regulates transcription of genes encoding proteins in metabolism and excretion of xenobi...
    • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
      Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    chaperone cofactor-dependent protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of cellular response to heat TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome HDA PubMed 
    membrane HDA PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily C member 7
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 7
    TPR repeat protein 2
    tetratricopeptide repeat domain 2
    tetratricopeptide repeat protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144766.2NP_001138238.1  dnaJ homolog subfamily C member 7 isoform 2

      See identical proteins and their annotated locations for NP_001138238.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC105024, AC125257, AK298860, BQ445927
      Consensus CDS
      CCDS45678.1
      UniProtKB/Swiss-Prot
      Q99615
      Related
      ENSP00000394327.2, ENST00000426588.7
      Conserved Domains (4) summary
      COG0484
      Location:324413
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:201228
      TPR; TPR repeat [structural motif]
      cl26002
      Location:3302
      TPR_11; TPR repeat
      cl26005
      Location:197297
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    2. NM_003315.4NP_003306.3  dnaJ homolog subfamily C member 7 isoform 1

      See identical proteins and their annotated locations for NP_003306.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC011837, BQ445927, BX647209
      Consensus CDS
      CCDS45677.1
      UniProtKB/Swiss-Prot
      Q99615
      Related
      ENSP00000406463.2, ENST00000457167.9
      Conserved Domains (4) summary
      COG0484
      Location:380469
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:257284
      TPR; TPR repeat [structural motif]
      cl26002
      Location:35386
      TPR_11; TPR repeat
      cl26005
      Location:253353
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    RNA

    1. NR_029431.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC105024, BC003601, BQ445927

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      41976421..42021371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525168.3XP_011523470.1  dnaJ homolog subfamily C member 7 isoform X1

      See identical proteins and their annotated locations for XP_011523470.1

      UniProtKB/Swiss-Prot
      Q99615
      Conserved Domains (4) summary
      COG0484
      Location:324413
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:201228
      TPR; TPR repeat [structural motif]
      cl26002
      Location:3302
      TPR_11; TPR repeat
      cl26005
      Location:197297
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    2. XM_011525169.3XP_011523471.1  dnaJ homolog subfamily C member 7 isoform X1

      See identical proteins and their annotated locations for XP_011523471.1

      UniProtKB/Swiss-Prot
      Q99615
      Conserved Domains (4) summary
      COG0484
      Location:324413
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:201228
      TPR; TPR repeat [structural motif]
      cl26002
      Location:3302
      TPR_11; TPR repeat
      cl26005
      Location:197297
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    3. XM_017024994.2XP_016880483.1  dnaJ homolog subfamily C member 7 isoform X1

      UniProtKB/Swiss-Prot
      Q99615
      Conserved Domains (4) summary
      COG0484
      Location:324413
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:201228
      TPR; TPR repeat [structural motif]
      cl26002
      Location:3302
      TPR_11; TPR repeat
      cl26005
      Location:197297
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    4. XM_011525167.3XP_011523469.1  dnaJ homolog subfamily C member 7 isoform X1

      See identical proteins and their annotated locations for XP_011523469.1

      UniProtKB/Swiss-Prot
      Q99615
      Related
      ENSP00000313311.7, ENST00000316603.11
      Conserved Domains (4) summary
      COG0484
      Location:324413
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      sd00006
      Location:201228
      TPR; TPR repeat [structural motif]
      cl26002
      Location:3302
      TPR_11; TPR repeat
      cl26005
      Location:197297
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    RNA

    1. XR_001752602.2 RNA Sequence

      Related
      ENST00000588814.5
    2. XR_001752603.2 RNA Sequence

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