U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    TRAF2 TNF receptor associated factor 2 [ Homo sapiens (human) ]

    Gene ID: 7186, updated on 2-May-2024

    Summary

    Official Symbol
    TRAF2provided by HGNC
    Official Full Name
    TNF receptor associated factor 2provided by HGNC
    Primary source
    HGNC:HGNC:12032
    See related
    Ensembl:ENSG00000127191 MIM:601895; AllianceGenome:HGNC:12032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRAP; TRAP3; RNF117; MGC:45012
    Summary
    The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 3.4), spleen (RPKM 3.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRAF2 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (136881958..136926607)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149116134..149160997)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139780968..139821059)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139752096-139752733 Neighboring gene MAM domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20556 Neighboring gene endothelial differentiation related factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29334 Neighboring gene uncharacterized LOC105376326 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20558 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139780929-139781664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139781665-139782400 Neighboring gene microRNA 4479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139831896-139832509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139832510-139833122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139837603-139838368 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20561 Neighboring gene F-box and WD repeat domain containing 5 Neighboring gene complement C8 gamma chain

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef The interaction of HIV-1 Nef with TRAF2, TRAF5, and TRAF6 proteins activates NF-kappaB, leading to the degradation of IkappaB-alpha and the increased phosphorylation of IKK-alpha and IKK-beta in monocyte-derived macrophages PubMed
    nef HIV-1 Nef interacts with TRAF2, TRAF5, and TRAF6 proteins via its C-terminal region (residues 55-206) in monocyte-derived macrophages PubMed
    nef The acidic cluster AQEEEE (residues 64-69) of HIV-1 Nef binds to the residues R393, R403, F447, S454, and F456 of TRAF2 PubMed
    nef TRAF2 and TRAF6 proteins are required for the HIV-1 Nef-induced tyrosine phosphorylation of STAT1 and STAT2 proteins PubMed
    Vpr vpr HIV-1 Vpr-mediated CASP8 (caspase 8) activation is mediated by TRAF-2 in THP-1 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CD40 receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mitogen-activated protein kinase kinase kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sphingolipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thioesterase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tumor necrosis factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tumor necrosis factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to nitric oxide IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_positive_effect innate immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-17-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mRNA stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of glial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in non-canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in programmed necrotic cell death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autoubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction involved in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CD40 receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of IRE1-TRAF2-ASK1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of TRAF2-GSTP1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasmic side of plasma membrane IC
    Inferred by Curator
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of plasma membrane signaling receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of tumor necrosis factor receptor superfamily complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    TNF receptor-associated factor 2
    Names
    E3 ubiquitin-protein ligase TRAF2
    RING-type E3 ubiquitin transferase TRAF2
    tumor necrosis factor type 2 receptor associated protein 3
    NP_066961.2
    XP_011517278.1
    XP_011517279.1
    XP_047279784.1
    XP_047279785.1
    XP_054219689.1
    XP_054219690.1
    XP_054219691.1
    XP_054219692.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021138.4NP_066961.2  TNF receptor-associated factor 2

      See identical proteins and their annotated locations for NP_066961.2

      Status: REVIEWED

      Source sequence(s)
      BC043492, BC064662
      Consensus CDS
      CCDS7013.1
      UniProtKB/Swiss-Prot
      A8K107, B4DPJ7, Q12933, Q7Z337, Q96NT2
      UniProtKB/TrEMBL
      E5KBQ3
      Related
      ENSP00000247668.2, ENST00000247668.7
      Conserved Domains (5) summary
      cd03778
      Location:334497
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:178235
      zf-TRAF; TRAF-type zinc finger
      pfam16673
      Location:267329
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
      cd16639
      Location:3273
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl28410
      Location:28157
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      136881958..136926607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518976.4XP_011517278.1  TNF receptor-associated factor 2 isoform X2

      See identical proteins and their annotated locations for XP_011517278.1

      UniProtKB/Swiss-Prot
      A8K107, B4DPJ7, Q12933, Q7Z337, Q96NT2
      UniProtKB/TrEMBL
      E5KBQ3
      Conserved Domains (5) summary
      cd03778
      Location:334497
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:178235
      zf-TRAF; TRAF-type zinc finger
      pfam16673
      Location:267329
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
      cd16639
      Location:3273
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl28410
      Location:28157
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    2. XM_011518977.3XP_011517279.1  TNF receptor-associated factor 2 isoform X2

      See identical proteins and their annotated locations for XP_011517279.1

      UniProtKB/Swiss-Prot
      A8K107, B4DPJ7, Q12933, Q7Z337, Q96NT2
      UniProtKB/TrEMBL
      E5KBQ3
      Conserved Domains (5) summary
      cd03778
      Location:334497
      MATH_TRAF2; Tumor Necrosis Factor Receptor (TNFR) Associated Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of transcription factors and the ...
      pfam02176
      Location:178235
      zf-TRAF; TRAF-type zinc finger
      pfam16673
      Location:267329
      TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain
      cd16639
      Location:3273
      RING-HC_TRAF2; RING finger, HC subclass, found in tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and similar proteins
      cl28410
      Location:28157
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    3. XM_047423829.1XP_047279785.1  TNF receptor-associated factor 2 isoform X2

      UniProtKB/Swiss-Prot
      A8K107, B4DPJ7, Q12933, Q7Z337, Q96NT2
    4. XM_047423828.1XP_047279784.1  TNF receptor-associated factor 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      149116134..149160997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363717.1XP_054219692.1  TNF receptor-associated factor 2 isoform X2

      UniProtKB/Swiss-Prot
      A8K107, B4DPJ7, Q12933, Q7Z337, Q96NT2
    2. XM_054363715.1XP_054219690.1  TNF receptor-associated factor 2 isoform X2

      UniProtKB/Swiss-Prot
      A8K107, B4DPJ7, Q12933, Q7Z337, Q96NT2
    3. XM_054363716.1XP_054219691.1  TNF receptor-associated factor 2 isoform X2

      UniProtKB/Swiss-Prot
      A8K107, B4DPJ7, Q12933, Q7Z337, Q96NT2
    4. XM_054363714.1XP_054219689.1  TNF receptor-associated factor 2 isoform X1